Bactocan (50mg/5ml) 35ml Suspension

Fluconazole 50mg syrup/suspension primarily acts by inhibiting the enzyme lanosterol 14-alpha-demethylase, which is crucial for the synthesis of ergosterol, a vital component of fungal cell membranes. By blocking this enzyme, fluconazole disrupts the integrity of fungal cell membranes, leading to the leakage of intracellular components and ultimately causing fungal cell death. This selective inhibition makes fluconazole particularly effective against various fungal species, including those causing systemic and mucosal infections.

Fluconazole 50mg

Antifungal, azole derivative.

Suspension

The following are the uses of Fluconazole 50mg Syrup/Suspension:

• Used for treating fungal infections such as candidiasis in the mouth, throat, and esophagus.
• Used for managing fungal infections in patients with weakened immune systems.
• Effective for treating fungal skin infections like ringworm, athlete's foot, and jock itch.
• Used for preventing and managing fungal infections in patients undergoing chemotherapy or radiation therapy.
• Can be used to treat fungal infections in the bloodstream (candidemia).
• Provides relief for severe fungal diaper rash in infants.
• Used for long-term maintenance therapy to prevent recurrent fungal infections.

In the case of an overdose of Fluconazole 50mg Syrup/Suspension, it is important to recognize the potential symptoms and seek medical advice promptly. Common signs of overdose may include nausea, vomiting, and increased liver enzymes. If an overdose is suspected, contact a healthcare professional immediately for guidance. They may recommend specific treatments or interventions to manage the symptoms and ensure the patient's well-being.

In the case of a missed dose of Fluconazole 50mg Syrup/Suspension, it is important to take the missed dose as soon as you remember. However, if it is almost time for your next dose, skip the missed dose and continue with your regular dosing schedule. Do not double the dose to make up for a missed one. If you miss multiple doses, contact your healthcare provider for guidance on how to proceed and ensure you're taking the medication as prescribed.

To administer Fluconazole 50mg Syrup/Suspension, shake the bottle vigorously, then measure the prescribed dose using an accurate measuring device like a marked measuring spoon or oral syringe, and take it orally once daily as directed by your healthcare professional, with or without food, following the dosage instructions provided.

Following are the conditions/situations when Fluconazole 50mg Syrup/Suspension should not be used:

• Do not use if you are allergic to Fluconazole or other similar antifungal medications.
• Contraindicated in patients with a history of liver disease or severe liver problems.
• Avoid using this medication if you have a known heart condition, especially QT prolongation.
• Should not be used if you have a history of a rare hereditary problem of galactose intolerance, severe lactase deficiency, or glucose-galactose malabsorption.
• Not recommended for individuals with kidney problems or those on dialysis.
• Do not use if you are taking certain medications, such as cisapride, pimozide, or quinidine, due to potential drug interactions.
• Contraindicated in patients with a history of an irregular heartbeat (arrhythmia).
• Should not be used if you are pregnant or breastfeeding, unless directed by a healthcare professional.
• Not suitable for children unless prescribed by a pediatrician.

The side effects of Fluconazole 50mg Syrup/Suspension may include:

• Nausea and vomiting
• Diarrhea
• Abdominal pain
• Headache
• Dizziness
• Skin rash or itching
• Abnormal liver function tests
• Fatigue

Here are the precautions and warnings for Fluconazole 50mg Syrup/Suspension:

• Do not take Fluconazole if you are allergic to it or any other azole antifungal medications.
• Patients with liver or kidney problems should use Fluconazole with caution and under medical supervision as it is primarily eliminated by these organs.
• This medication may cause liver damage, especially in patients with pre-existing liver conditions. Regular monitoring of liver function is necessary during long-term treatment.
• Fluconazole can prolong the QT interval, so it should be used with caution in patients with a history of QT prolongation or heart rhythm disorders.
• It may interact with other drugs, including warfarin, phenytoin, and rifampicin, so inform your doctor about all medications you are taking.
• Avoid excessive alcohol consumption while taking Fluconazole as it may increase the risk of liver damage.
• Pregnant and breastfeeding women should consult their doctor before using Fluconazole, as it can be passed into breast milk and may affect the fetus or newborn.
• Keep out of reach of children and store in a cool, dry place, away from direct sunlight.

Following are the drug interactions for Fluconazole 50mg Syrup/Suspension:

• Concurrent use with warfarin may increase the risk of bleeding, as Fluconazole can enhance the anticoagulant effects of warfarin by inhibiting its metabolism.
• Fluconazole can increase the levels of certain medications metabolized by the liver (e.g., phenytoin, cyclosporine, tacrolimus), increasing the risk of side effects.
• Caution is advised when using Fluconazole with other drugs that affect liver enzymes (e.g., rifampicin, carbamazepine), as they can reduce the effectiveness of Fluconazole by increasing its metabolism.
• Fluconazole may interact with certain antiarrhythmic drugs (e.g., quinidine, amiodarone), increasing the risk of arrhythmias.
• Combining Fluconazole with certain antidepressants (e.g., tricyclic antidepressants or SSRIs) may increase the risk of serotonin syndrome, a rare but serious condition.
• Fluconazole may enhance the effects of certain benzodiazepines (e.g., diazepam, midazolam), leading to increased sedation or respiratory depression.
• Use with oral hypoglycemic agents (e.g., sulfonylureas) may increase the risk of hypoglycemia, requiring monitoring of blood sugar levels.
• Fluconazole may reduce the effectiveness of oral contraceptives, so alternative contraception methods should be considered.
• The use of Fluconazole with drugs that prolong the QT interval (e.g., certain antipsychotics, antibiotics) may increase the risk of torsades de pointes, a serious heart rhythm disturbance.

Following are the food interactions for Fluconazole 50mg Syrup/Suspension:

• Grapefruit and grapefruit juice should be consumed with caution as they may inhibit the metabolism of Fluconazole, leading to increased drug levels in the body and potentially enhancing side effects.
• Avoid excessive alcohol consumption as it may increase the risk of liver-related side effects and can also cause dizziness and drowsiness.
• Avoid high-fat meals as they can slow down the absorption of Fluconazole, potentially affecting its effectiveness.
• Avoid dairy products as they can interact with Fluconazole, reducing its absorption. Consider separating the medication and dairy intake by a few hours.
• Caffeine intake should be monitored as Fluconazole may increase caffeine levels in the body, potentially causing restlessness and insomnia.
• Avoid cranberry juice as it may decrease the effectiveness of Fluconazole, especially in treating urinary tract infections.
• Maintain a balanced diet to support overall health and consult your healthcare provider for specific dietary recommendations during Fluconazole treatment.
• Always follow the dosage instructions provided by your healthcare professional for optimal results.

Fluconazole 50mg Syrup/Suspension should be stored in a secure location, preferably in a locked cabinet or a designated medication storage area, ensuring it is out of reach of children and pets. Maintain a consistent room temperature, avoiding extreme heat or cold, direct sunlight, and moisture. Keep the syrup in its original container, tightly sealed, to maintain its integrity and prevent contamination. Regularly check the expiration date, and dispose of any unused or expired medication promptly. When disposing of Fluconazole syrup, do not pour it down the drain or flush it; instead, follow local guidelines or consult a pharmacist for safe disposal methods to minimize environmental impact. It is crucial to handle this medication with care and adhere to proper storage and disposal practices to ensure safety and efficacy.

Following are the quick tips for Fluconazole 50mg Syrup/Suspension:

• Ensure you follow the prescription guidelines provided by your healthcare professional for the best outcomes.
• Administer the recommended dosage using the calibrated measuring device provided.
• Mix the syrup/suspension well before each use for accurate dosing.
• Consume the syrup/suspension with a full glass of water for optimal absorption.
• Maintain a consistent daily routine for taking the medication to maximize its effectiveness.
• Store the medication at room temperature, away from direct sunlight and moisture.
• Do not hesitate to contact your doctor if you experience any unusual symptoms or side effects.