Baritec-A (40/5mg) 20 Tablets

Olmesartan and Amlodipine work synergistically to lower blood pressure. Olmesartan is an angiotensin II receptor blocker (ARB) that prevents the binding of angiotensin II to its receptors, thereby inhibiting the vasoconstrictor and aldosterone-secreting effects of angiotensin II, which leads to decreased blood pressure. Amlodipine, on the other hand, is a calcium channel blocker (CCB) that selectively inhibits calcium ion influx across cell membranes, which relaxes vascular smooth muscle and leads to vasodilation. By blocking calcium channels, amlodipine reduces peripheral vascular resistance, resulting in decreased blood pressure. The combination of these two mechanisms provides a more effective blood pressure-lowering effect.

Angiotensin II receptor blocker, calcium channel blocker.

Tablet

The following are the uses of Olmesartan 40mg, Amlodipine 5mg Tablet:

• Used for treating high blood pressure (hypertension)
• Used to lower blood pressure and reduce the risk of cardiovascular events
• Used for patients whose blood pressure is not controlled with single-drug therapy
• Used to improve blood flow and oxygen supply to the heart
• Used to prevent chest pain (angina)
• Used to manage conditions like coronary artery disease and peripheral vascular disease
• Used to improve overall heart health and reduce strain on the heart
• Used for long-term management of blood pressure and related complications

To be taken as per doctor's prescription

In the case of an overdose of Olmesartan 40mg and Amlodipine 5mg tablets, individuals may experience symptoms such as severe dizziness, fainting, or an irregular heartbeat. It is important to seek medical advice promptly if you suspect an overdose. Depending on the severity, treatment may include monitoring vital signs, providing supportive care, and potentially administering medications to counteract the effects of the overdose. Quick action can help manage symptoms and prevent potential complications.

In the case of a missed dose of Olmesartan 40mg, Amlodipine 5mg Tablet, it is recommended to take the missed dose as soon as you remember. However, if it is almost time for your next scheduled dose, skip the missed dose and continue with your regular dosing schedule. It is important not to double the dose to make up for a missed one, as this may increase the risk of side effects. If you miss multiple doses, contact your healthcare provider for guidance on how to safely resume your medication. It is advisable to set reminders or alarms to help you remember to take your medication as prescribed.

To take the Olmesartan 40mg, Amlodipine 5mg Tablet, swallow the tablet whole with a full glass of water, preferably at the same time each day, following the dosage instructions provided by your healthcare professional.

Following are the conditions when Olmesartan 40mg, Amlodipine 5mg Tablet should not be used:

• Should not be used in patients with a known allergy to Olmesartan, Amlodipine, or other related medications.
• Contraindicated in patients with a history of angioedema (swelling of the face, lips, tongue, or throat) after taking Amlodipine or other similar drugs.
• Not suitable for individuals with severe liver disease or impaired liver function.
• Should be avoided in pregnant or breastfeeding women.
• Should not be used in patients with severe kidney disease or those on dialysis.
• Contraindicated in individuals with a condition called aortic stenosis (narrowing of the aortic valve in the heart).

The side effects of Olmesartan 40mg, Amlodipine 5mg Tablet may include:

• Dizziness or lightheadedness
• Fatigue or weakness
• Headache
• Nausea or stomach pain
• Swelling in the ankles, feet, or legs
• Muscle cramps
• Increased sensitivity to sunlight
• Skin rash or itching

Following are the precautions and warnings for Olmesartan 40mg, Amlodipine 5mg Tablet:

• Patients with a known allergy to Olmesartan, Amlodipine, or any other angiotensin II receptor blockers (ARBs) should not take this medication.
• Kidney function should be monitored regularly, especially in patients with pre-existing kidney problems, as the medication can affect renal function.
• This medication may cause dizziness and lightheadedness, especially when standing up suddenly; caution is advised when performing tasks that require alertness.
• It is crucial to maintain proper fluid intake and monitor blood pressure regularly, especially during initial treatment.
• Patients with a history of liver disease should exercise caution and have their liver function monitored while on this medication.
• Amlodipine may cause swelling in the feet and ankles; seek medical advice if this becomes severe or persistent.
• Elderly patients may be more sensitive to the effects of this medication, particularly dizziness and hypotension.
• Consult a healthcare professional before taking this medication if you are pregnant, planning to become pregnant, or breastfeeding.

Following are the drug interactions for Olmesartan 40mg, Amlodipine 5mg Tablet:

• Drugs that increase serum potassium levels (e.g., ACE inhibitors, potassium-sparing diuretics) may lead to hyperkalemia when used with Olmesartan.
• Concomitant use with NSAIDs may reduce the antihypertensive effect and increase the risk of renal impairment.
• Amlodipine can interact with CYP3A4 inhibitors (e.g., ketoconazole, clarithromycin), leading to increased amlodipine levels and enhanced side effects.
• Drugs metabolized by CYP3A4 (e.g., cyclosporine, simvastatin) may have elevated concentrations when used with amlodipine.
• Calcium channel blockers, beta-blockers, and digoxin may have additive effects on blood pressure and heart rate.
• Grapefruit juice can inhibit the metabolism of amlodipine, potentially increasing its blood levels.
• Rifampicin, a CYP3A4 inducer, may decrease the effectiveness of amlodipine.

Following are the food interactions for Olmesartan 40mg, Amlodipine 5mg Tablet:

• Grapefruit and grapefruit juice should be consumed with caution as they may increase the blood pressure-lowering effect of Amlodipine, potentially leading to excessive blood pressure reduction and related side effects.
• Avoid excessive alcohol consumption as it can enhance the blood pressure-lowering effect of Amlodipine, increasing the risk of side effects like dizziness and lightheadedness.
• Potassium-rich foods like bananas, oranges, and spinach should be consumed moderately, as Amlodipine can sometimes lead to potassium retention, and excessive intake may cause hyperkalemia.
• Salt substitutes containing potassium should be used with caution, as Amlodipine may cause potassium levels to rise, and excessive use could lead to hyperkalemia.
• No significant food interactions are known for Olmesartan, but it's best to follow the advice of your healthcare provider regarding dietary considerations.
• A balanced diet is generally recommended to support overall health and manage blood pressure effectively.
• Always consult your healthcare provider for personalized dietary advice based on your specific health condition and medication regimen.

Olmesartan 40mg, Amlodipine 5mg Tablets should be stored in a cool and dry place, preferably at room temperature, ensuring protection from light and moisture. The original container should be tightly sealed to maintain its integrity and prevent contamination. Avoid storing the tablets in the bathroom or near heat-emitting appliances, as high temperatures and humidity can degrade the medication. Always check the expiration date before use, and properly dispose of any unused or expired tablets by following local guidelines or consulting a pharmacist for appropriate disposal methods. Keep the medication out of children's reach to prevent accidental consumption. Never flush or pour the tablets down the drain unless instructed to do so, as this can have environmental implications.

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Following are the quick tips for Olmesartan 40mg, Amlodipine 5mg Tablet:

• Take the tablet as directed by your doctor, typically once daily.
• Consistency is key; take it at the same time each day.
• Swallow the tablet whole with a full glass of water.
• Avoid crushing, chewing, or breaking the tablet.
• You can take it with or without food, but be consistent.
• If you miss a dose, take it as soon as you remember, unless it's almost time for the next dose.
• Regularly monitor your blood pressure as advised by your doctor.