Benzibiotic (1.2 Million Unit) 1 Injection

Benzathine Penicillin, a long-acting antibiotic, exerts its bactericidal effect by inhibiting the synthesis of bacterial cell walls. It specifically targets penicillin-binding proteins (PBPs) in susceptible bacteria, such as Streptococcus and Staphylococcus species. Benzathine Penicillin binds to PBPs, preventing the cross-linking of peptidoglycan chains, which are essential for maintaining the structural integrity of the bacterial cell wall. This interference leads to the weakening and eventual rupture of the cell wall, resulting in bacterial cell lysis and death. The unique characteristic of benzathine penicillin is its slow absorption and sustained release from the injection site, providing prolonged therapeutic levels of the drug in the bloodstream, allowing for less frequent dosing and ensuring effective treatment of certain infections.

Benzathine Penicillin

Penicillin antibiotic

injection

The following are the uses of Benzathine Penicillin injection:

• Used for the treatment of syphilis, providing a long-acting alternative for patients with this sexually transmitted infection.
• Used for preventing recurrent rheumatic fever, helping to reduce the risk of flare-ups and associated heart complications.
• Used for the management of streptococcal infections, offering a targeted approach to combat these bacterial infections.
• Used for treating chronic forms of osteomyelitis, ensuring a sustained release of medication to combat bone infections.
• Used for managing certain skin and soft tissue infections, providing a therapeutic option for severe or recurrent cases.
• Used for prophylaxis in individuals with a history of recurrent severe infections, helping to prevent future episodes.
• Used for specific upper respiratory tract infections, offering a solution for severe or persistent cases.

In the case of an overdose of Benzathine Penicillin injection, it is crucial to monitor the patient for potential adverse effects. These effects may include gastrointestinal disturbances, hypersensitivity reactions, or neurological symptoms. Prompt medical intervention is essential to manage any complications and provide supportive care. Treatment should focus on addressing the specific symptoms presented by the patient, ensuring their well-being and recovery.

In the case of a missed dose of Benzathine Penicillin injection, it is important to administer the missed dose as soon as possible. However, if it is almost time for the next scheduled dose, it is best to skip the missed dose and continue with the regular dosing schedule. Never double the dose to make up for a missed one, as this may increase the risk of side effects. It is advisable to mark a calendar or set reminders to ensure you stay on track with your medication regimen and minimize the chances of missing future doses.

To administer the Benzathine Penicillin injection, clean the injection site with an alcohol swab, insert the needle at a 90-degree angle into the muscle, inject the medication slowly, and then withdraw the needle while applying pressure with a sterile gauze pad to prevent bleeding.

Here are the situations when Benzathine Penicillin injection should not be used:

• Should not be administered to individuals with a history of severe allergic reactions to penicillin or any other beta-lactam antibiotics.
• Contraindicated in patients with a known allergy to any of its ingredients, including benzathine or penicillin derivatives.
• Not recommended for patients with a history of immediate-type hypersensitivity reactions, such as hives, angioedema, or anaphylaxis, to any antibiotic in the penicillin class.
• Should not be used in patients with a history of or active lymphocytic leukemia, as it may worsen the condition.
• Contraindicated in patients with a history of or suspected cerebrovascular or spinal cord lesions, as it may increase the risk of neurological complications.
• Not suitable for patients with severe renal impairment or kidney disease, as dosage adjustments may not be sufficient to ensure safety.
• Should not be used in patients with a history of mononucleosis, as it may increase the risk of skin rash.

The side effects of Benzathine Penicillin injection may include:

• Pain, swelling, or redness at the injection site
• Allergic reactions, such as rash, itching, or hives
• Nausea and vomiting
• Diarrhea
• Fever
• Joint pain
• Fatigue
• Dizziness

Following are the precautions and warnings for Benzathine Penicillin injection:

• Allergic reactions can occur; ensure immediate access to emergency equipment and medications to manage anaphylaxis.
• Should not be administered to individuals with a history of penicillin allergy or sensitivity.
• May cause diarrhea, and prolonged use may lead to the overgrowth of dangerous bacteria or fungi.
• Monitor patients for signs of superinfection during therapy.
• Prolonged use may also result in oral thrush or new yeast infections.
• Not recommended for use in patients with mononucleosis due to increased risk of skin rash.
• Caution in patients with a history of kidney disease, as dosage adjustments may be necessary.

Following are the drug interactions for Benzathine Penicillin injection:

• Probenecid can reduce the excretion of penicillin, increasing its blood levels and risk of side effects.
• Tetracyclines may interfere with the absorption of Benzathine Penicillin, reducing its effectiveness.
• Concomitant use with methotrexate can increase methotrexate levels, requiring dose adjustments.
• May decrease the effectiveness of oral contraceptives, requiring additional contraceptive measures.
• Concurrent use with anticoagulants may increase bleeding risk, necessitating close monitoring.
• Can potentially reduce the efficacy of mycophenolate, an immunosuppressant, requiring careful monitoring.
• May enhance the effects of neuromuscular blocking agents, requiring dosage adjustments.

Following are the food interactions to be aware of with Benzathine Penicillin injection:

• Avoid consuming alcohol during the treatment period as it may increase the risk of side effects and interfere with the antibiotic's effectiveness.
• Maintain a balanced diet to support overall health and ensure proper absorption of the medication.
• Stay hydrated by drinking adequate fluids, especially water, to aid in the distribution and elimination of the antibiotic.
• Avoid grapefruit and grapefruit juice as they can interfere with the metabolism of some medications, although specific interactions with Benzathine Penicillin are not well-documented.
• Ensure a consistent intake of vitamin-rich foods to support the immune system and aid in recovery.
• There is no specific requirement to consume high-fat meals with this medication, as it is an injection and not an oral medication.
• No known significant interactions with specific foods for Benzathine Penicillin injection are reported.

Benzathine Penicillin injection should be stored in a refrigerator at a temperature between 2°C and 8°C (36°F and 46°F). It is crucial to keep the injection in its original packaging, protected from light and moisture, and ensure the package is tightly sealed. Do not freeze the medication, as freezing can damage its potency. Always check the expiration date before use, and discard any expired or unused injections according to local regulations and guidelines. When disposing of the medication, do not throw it into the trash or pour it down the drain; instead, follow the recommended disposal practices in your area to minimize environmental impact. Keep the medication out of children's reach to prevent accidental exposure.

Following are the quick tips for Benzathine Penicillin injection:

• Benzathine Penicillin is administered by a healthcare professional, ensuring proper dosage and administration.
• This injection is typically given into the muscle, usually in the buttock or thigh.
• Inform your doctor if you have any allergies or medical conditions before receiving the injection.
• It is common to experience mild pain, swelling, or redness at the injection site, but contact your doctor if it persists.
• Avoid missing doses; complete the full course as prescribed for maximum effectiveness.
• If you experience severe side effects like difficulty breathing, seek immediate medical attention.
• Store the injection as directed by your pharmacist or healthcare provider.