BERIRAB P INJ

Pasteurized Human Rabies Immunoglobulin (HRIG) Injection works primarily by binding to and neutralizing the rabies virus. It is a preparation of antibodies derived from human donors with high rabies antibody titers. When administered, HRIG provides immediate passive immunity against rabies. The mechanism involves the specific binding of the immunoglobulin G (IgG) antibodies present in HRIG to the viral surface antigens, primarily the glycoprotein on the rabies virus. This binding prevents the virus from attaching to and entering target cells, thereby inhibiting viral replication and spread. The neutralizing antibodies in HRIG also help opsonize the virus, marking it for destruction by the immune system's phagocytic cells, thus contributing to the rapid clearance of the rabies virus from the body.

Rabies Immunoglobulin

injection

The following are the uses of Pasteurized Human Rabies Immunoglobulin Injection:

• Used for immediate post-exposure prophylaxis against rabies infection
• Used for neutralizing the rabies virus
• Used as an essential component in the treatment of rabies exposure
• Used to provide rapid and effective immunity
• Used in cases where there is a high risk of rabies transmission
• Used to prevent the virus from reaching the central nervous system
• Used as an adjunct to the rabies vaccine for enhanced protection

In the case of an overdose of Pasteurized Human Rabies Immunoglobulin Injection, it is important to seek medical advice promptly. Symptoms of an overdose may include localized pain, swelling, or irritation at the injection site, and possibly more severe systemic reactions such as anaphylaxis. Treatment should focus on managing these symptoms and providing supportive care, ensuring the patient's vital signs are monitored closely. Further management will depend on the severity of the reaction and the patient's overall health.

In the case of a missed dose of Pasteurized Human Rabies Immunoglobulin Injection, it is crucial to contact your healthcare provider immediately for guidance. The timing of the injection is critical for its effectiveness, and a missed dose can impact the overall treatment plan. Your healthcare provider will determine the best course of action, which may involve administering the missed dose as soon as possible or adjusting the remaining doses to ensure optimal protection against rabies.

To administer the Pasteurized Human Rabies Immunoglobulin Injection, clean the injection site with alcohol, insert the needle at a 45-degree angle, inject the prescribed dose subcutaneously or intramuscularly as directed by your healthcare provider, and gently press a dry cotton ball over the injection site after withdrawing the needle.

Here are the conditions and situations when Pasteurized Human Rabies Immunoglobulin Injection should not be used:

• Do not use if the patient has a history of severe allergic reactions to human immune globulin or other blood products.
• Not recommended for individuals with severe immunoglobulin A (IgA) deficiency, as they may develop antibodies against IgA.
• Contraindicated in patients with a history of anaphylaxis to human immunoglobulin preparations.
• Avoid if the patient has a history of thrombosis or a known risk of thrombosis, as it may increase the risk of blood clots.
• Should not be used in individuals with severe kidney disease or a history of kidney failure.
• Not suitable for patients with severe active infections, as it may mask the symptoms and delay proper treatment.
• Do not administer if there is a known sensitivity to any of the injection components.
• Contraindicated in individuals with a history of heart problems or cardiovascular disease.

The side effects of Pasteurized Human Rabies Immunoglobulin Injection may include:

• Pain, swelling, or redness at the injection site
• Headache
• Nausea and vomiting
• Joint or muscle pain
• Fever
• Dizziness
• Fatigue
• Skin rash

Following are the precautions and warnings for Pasteurized Human Rabies Immunoglobulin Injection:

• Do not administer if the patient has a history of hypersensitivity or severe allergic reactions to human immune globulin products.
• Exercise caution in patients with a history of thrombosis or coagulation disorders, as it may increase the risk of thromboembolic events.
• Ensure proper hydration before and after administration to reduce the risk of renal complications.
• Monitor for signs of anaphylaxis during and after injection, especially in individuals with a history of allergies.
• Do not inject intravascularly; it is intended for intramuscular use only.
• Use with caution in immunocompromised patients as it may carry a risk of transmitting infectious agents.
• Discontinue use if symptoms of meningitis or other neurological complications occur.
• Patients should be informed about the importance of completing the full course of post-exposure rabies prophylaxis.

Following are the drug interactions for Pasteurized Human Rabies Immunoglobulin Injection:

• Concomitant use with live virus vaccines (e.g., measles, mumps, rubella) may result in replication of the vaccine virus and potential adverse events. Vaccination should be deferred until after immunoglobulin therapy.
• Thrombocytopenia can occur with high doses of intravenous immunoglobulin, particularly in patients with pre-existing risk factors. Monitor platelet counts.
• Pasteurized Human Rabies Immunoglobulin may interfere with the response to live attenuated viral vaccines such as measles, mumps, and rubella due to neutralizing antibodies. Consider deferring vaccination until after treatment.
• Concurrent use of prothrombin complex concentrates or other coagulation factors may increase the risk of thrombosis. Monitor for signs of thrombosis.
• It can inhibit the immune response to vaccines containing live attenuated viruses like varicella and zoster. Schedule vaccinations accordingly.
• May interact with antineoplastic agents, potentially affecting the efficacy of chemotherapy. Monitor closely during combination therapy.
• The use of other immunoglobulin products or plasma-derived therapies may increase the risk of volume overload and hyperviscosity, especially in patients with renal impairment.

Following are the food interactions for Pasteurized Human Rabies Immunoglobulin Injection:

• No specific food interactions are known with this medication, but it's advisable to consult your doctor or pharmacist for personalized advice.
• Generally, maintaining a balanced diet is recommended to support overall health during treatment.
• There is no evidence suggesting that any particular food or beverage should be avoided while receiving this injection.
• You can continue your regular diet unless advised otherwise by your healthcare professional.
• The injection's effectiveness is unlikely to be influenced by dietary choices.
• Ensure you stay well-hydrated, especially after receiving the injection.
• If you have any specific dietary restrictions or concerns, discuss them with your healthcare provider.

Storage and disposal of Pasteurized Human Rabies Immunoglobulin Injection are crucial. Store the injection in a refrigerator at 2°C to 8°C (36°F to 46°F), protected from light. Do not freeze, as freezing can damage the medication. Ensure the injection is kept in its original packaging to maintain sterility. Do not use the injection if it has been exposed to extreme temperatures or if the solution appears cloudy or discolored. Dispose of any unused or expired medication through a medicine take-back program or by mixing it with an undesirable substance (like used coffee grounds or kitty litter) and placing it in a sealed bag in the trash, ensuring it is out of reach of children and pets.

Following are the quick tips for Pasteurized Human Rabies Immunoglobulin Injection:

• Ensure the injection is administered by a trained healthcare professional.
• Verify the medication's expiry date before use.
• Inform your doctor about any allergies or medical conditions you have.
• Relax and stay still during the injection to ensure proper administration.
• Report any unusual reactions or side effects to your doctor immediately.
• Dispose of used needles and syringes safely in designated sharps containers.
• Store the medication as directed, away from direct sunlight and extreme temperatures.