Betnesol (4mg) 1ml, 5 Ampoule Injections

Betamethasone, a potent synthetic glucocorticoid, exerts its therapeutic effects primarily through its interaction with intracellular glucocorticoid receptors. Once bound to these receptors, the betamethasone-receptor complex migrates to the nucleus, where it regulates gene expression by either enhancing or suppressing the transcription of specific genes. This leads to the synthesis of proteins that mediate anti-inflammatory, immunosuppressive, and vasoconstrictive actions. The drug inhibits the release of inflammatory mediators, such as prostaglandins and leukotrienes, and suppresses the immune response by reducing the production and activity of immune cells. It also stabilizes lysosomal membranes, inhibits the formation of collagen, and decreases capillary permeability, contributing to its anti-inflammatory and vasoconstrictive effects. The mechanism of action results in reduced inflammation, edema, and immune system activity, making betamethasone useful in the management of various inflammatory and autoimmune conditions.

Betamethasone

Corticosteroid

Injection

The following are the uses of Betamethasone Injection:

• Used for reducing inflammation and suppressing the immune system.
• Used for treating severe allergic reactions and asthma attacks.
• Used for managing rheumatoid arthritis and other autoimmune conditions.
• Used for alleviating symptoms of ulcerative colitis and Crohn's disease.
• Used for treating certain skin disorders like eczema and psoriasis.
• Used for preventing organ rejection after a transplant.
• Used for relieving symptoms of multiple sclerosis.
• Used for managing certain types of cancer.

To be used as per doctor's prescription

In the case of an overdose of Betamethasone Injection, prompt medical attention is necessary. Symptoms may include weight gain, fluid retention, increased blood pressure, and behavioral changes. Medical professionals should be contacted immediately to manage the overdose effectively. Treatment may involve supportive care and addressing specific symptoms to prevent further complications. It is crucial to follow the prescribed dosage to avoid such instances.

In the case of a missed dose of Betamethasone Injection, it is important to act promptly to maintain the medication's effectiveness. If you realize you've missed a dose, administer it as soon as possible, but avoid doubling the dose to compensate. If it's almost time for your next scheduled dose, simply skip the missed dose and continue with your regular dosing schedule. Always keep a consistent interval between doses to ensure optimal therapeutic benefits. Consult your healthcare provider if you have any concerns or if you miss multiple doses.

To administer the Betamethasone Injection, clean the injection site with an alcohol wipe, insert the needle at a 90-degree angle, and slowly inject the prescribed dose subcutaneously, ensuring the entire medication is delivered before withdrawing the needle.

Following are the conditions/situations when Betamethasone Injection should not be used:

• Must not be administered to individuals with a known hypersensitivity or allergy to Betamethasone or other similar corticosteroids.
• Not suitable for patients with systemic fungal infections as it can worsen the condition.
• Contraindicated in patients with widespread bacterial infections unless specific anti-infective therapy is also given.
• Should not be used to treat viral infections, including common colds or flu.
• Not recommended for patients with tuberculosis or untreated infections.
• Betamethasone injection should not be used for vaccination procedures.
• Not suitable for patients with gastrointestinal perforation or abscess.
• Must not be used in individuals with recent intestinal anastomoses.
• Contraindicated in patients with severe psychiatric disorders, including psychotic reactions or severe depression.
• Should be avoided in patients with idiopathic thrombocytopenic purpura (ITP) as it can worsen the condition.
• Not recommended for patients with severe osteoporosis.
• Should not be used in patients with uncontrolled diabetes.
• Betamethasone injection is not suitable for pregnant women, especially during the first trimester, unless clearly needed.
• It should be used with caution in breastfeeding mothers due to the potential risks to the infant.

The side effects of Betamethasone Injection may include:

• Increased appetite and weight gain
• Nausea, indigestion, or stomach irritation.
• Weakness of muscles
• Skin thinning, bruising, or discolouration at the injection site.
• Mood changes, including feeling depressed or irritable.
• Difficulty sleeping (insomnia)
• Increased blood sugar levels (hyperglycemia)
• Delayed wound healing

Following are the precautions and warnings for Betamethasone Injection:

• Betamethasone Injection should be used with caution in patients with a history of allergies to any steroids or other medications, as it may trigger an allergic reaction.
• It is crucial to monitor blood pressure and blood sugar levels regularly during treatment, as Betamethasone can cause hypertension and elevated glucose levels.
• Patients with existing infections should be closely monitored as this medication can mask the symptoms and worsen the infection.
• Betamethasone may cause fluid retention, so caution is advised in patients with heart, kidney, or liver diseases.
• Not recommended for long-term use due to potential side effects; prolonged use can lead to adrenal suppression.
• May cause muscle weakness, especially in the upper arms and thighs, and can affect bone density; regular exercise and calcium/vitamin D supplements may be recommended.
• Pregnant or breastfeeding women should consult their doctor before using Betamethasone, as it can pass into breast milk and affect fetal development.
• Always follow the prescribed dosage and duration of treatment to avoid potential complications.

Following are the drug interactions for Betamethasone Injection:

• Rifampicin, a strong enzyme inducer, can reduce the effects of betamethasone by increasing its metabolism.
• Combining with non-steroidal anti-inflammatory drugs (NSAIDs) may increase the risk of gastrointestinal ulcers and bleeding.
• The risk of hypokalemia and hypokalemic alkalosis rises when used with potassium-depleting diuretics.
• Antidiabetic medications may require adjustment due to betamethasone's hyperglycemic effects.
• The combination with antiepileptic drugs like phenytoin or carbamazepine can lead to decreased plasma concentrations of these drugs.
• Live virus vaccines should be avoided as betamethasone may impair the immune response, reducing vaccine effectiveness.
• Anticoagulants like warfarin may have their effects altered, requiring close monitoring of coagulation parameters.

Following are the food interactions for Betamethasone Injection:

• Betamethasone can increase appetite, so be mindful of excessive calorie intake and maintain a balanced diet.
• Avoid high-sodium foods as Betamethasone can cause sodium retention, leading to fluid retention and increased blood pressure.
• Limit sugary foods and beverages as corticosteroids like Betamethasone can affect blood sugar levels.
• Consume potassium-rich foods like bananas, oranges, and spinach to counter potential potassium loss caused by Betamethasone.
• Maintain a calcium-rich diet with dairy products, leafy greens, and fortified foods to support bone health, as Betamethasone can affect calcium absorption.
• Limit or avoid caffeine as it can exacerbate insomnia, a potential side effect of Betamethasone.
• Ensure adequate fluid intake to reduce the risk of gastrointestinal side effects associated with corticosteroids.

Betamethasone Injection should be stored in a controlled environment, preferably at room temperature between 20°C and 25°C (68°F to 77°F). Protect the injection vials from light and moisture by keeping them in their original packaging until ready for use. It is crucial to maintain a clean and sterile environment when handling the injection to prevent contamination. Once a vial is opened, it should be used immediately, and any unused portion should be discarded properly. Do not reuse needles or syringes; dispose of them safely in designated sharps containers. When disposing of the medication, follow local guidelines for pharmaceutical waste disposal, or consult your healthcare provider for specific instructions to ensure safe and environmentally friendly disposal. Keep the injection out of the sight and reach of children and pets to prevent accidental exposure.

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Here are the quick tips for Betamethasone Injection:

• Administer the injection under medical supervision for the prescribed duration.
• Ensure proper injection technique to prevent injection site reactions.
• Do not abruptly stop the medication; follow your doctor's instructions for tapering.
• Inform your doctor about existing medical conditions, especially infections.
• Regular medical tests may be required to monitor side effects.
• Avoid contact with people who have contagious illnesses to prevent infection.
• Store the injection at room temperature, away from direct sunlight.