Bexovate-G 15g Cream

Betamethasone and gentamicin work together through a multi-step mechanism of action. Betamethasone is corticosteroid functions by inhibiting inflammation and immune responses. It penetrates target cells and binds to glucocorticoid receptors, leading to the suppression of pro-inflammatory gene expression. This action reduces swelling, redness, and pain in affected tissues. Gentamicin is aminoglycoside antibiotic penetrates bacterial cell membranes and binds to the 30S ribosomal subunit. This binding inhibits protein synthesis, which is crucial for bacterial growth and replication, ultimately leading to cell death. Gentamicin is particularly effective against a range of gram-negative bacteria.

Corticosteroid, Antibiotic

Betamethasone + Gentamycin combination is used for:

• Pain Relief
• Fever
• Inflammation
• Cardiovascular Prevention

Bexovate-G dosage for the indication of inflammatory skin conditions and bacterial infections, with a duration of 7-14 days or as directed:

• Adults - Apply a thin layer to affected areas 2-3 times daily.
• Children - Apply a thin layer 1-2 times daily.

Overdose of betamethasone may cause Cushing's syndrome. Overdose of gentamycin may lead to kidney or hearing problems. Seek immediate medical help.

If you miss a dose, consume as soon as you remember. If it is close to the next feeding, skip the missed dose. Do not double up on doses.

Betamethasone is applied topically as a thin layer to the affected area. Gentamycin is usually applied as an ointment. Follow the prescribed regimen.

Betamethasone, Gentamycin should not be used if:

• Hypersensitivity to either component
• Viral infections
• Tuberculosis (active)

Possible side effects of Betamethasone and Gentamycin include:

• Skin irritation
• Itching
• Rash
• Allergic reactions
• Nausea

The warnings and precautions associated with Betamethasone and Gentamycin are:

• Risk of systemic absorption of corticosteroids and aminoglycosides, especially with prolonged use.
• Increased risk of ototoxicity and nephrotoxicity with Gentamycin, particularly in patients with renal impairment.
• Caution in patients with diabetes, hypertension, or peptic ulcer disease.
• Pregnancy and lactation.

The drug interactions with betamethasone and gentamycin combination include:

• Betamethasone- Anticoagulants (e.g., warfarin) – Can enhance the effects of anticoagulants, increasing the risk of bleeding.
• Betamethasone- Antidiabetic Drugs – Can decrease the effectiveness of antidiabetic drugs.
• Gentamycin- Nephrotoxic Drugs (e.g., NSAIDs) – Can increase the risk of nephrotoxicity.

Betamethasone and gentamycin have no documented food interactions that affect their efficacy or safety. There are no specific dietary restrictions or food-related effects on their absorption. It is important to use both betamethasone and gentamycin according to your healthcare provider's instructions to ensure optimal results.

Betamethasone should be stored at room temperature, away from moisture and heat. Gentamycin should be stored as specified on the label, typically at room temperature, and protected from light. Dispose of any expired or unused medication properly, not by flushing. Use local disposal guidelines or a drug take-back program.