BEZALIP RATRD IMP 400MG TAB (BEZAFIBRATE)

Bezafibrate 400mg Tablet primarily acts as a pan-peroxisome proliferator-activated receptor (PPAR) agonist, meaning it activates all three subtypes of PPARs alpha, gamma, and delta. This mechanism of action allows Bezafibrate to exert multiple effects on lipid metabolism. It enhances the breakdown of triglyceride-rich particles, leading to reduced levels of triglycerides and very-low-density lipoprotein (VLDL) in the blood. The drug also increases the synthesis of high-density lipoprotein (HDL) cholesterol, often referred to as "good cholesterol," and can lead to a decrease in low-density lipoprotein (LDL) cholesterol levels. Additionally, Bezafibrate can improve insulin sensitivity, which can help regulate blood sugar levels and have beneficial effects on lipid metabolism. The activation of PPARs by Bezafibrate results in the modulation of gene expression, influencing various metabolic pathways related to lipid homeostasis and energy balance.

Bezafibrate 400mg

Fibrate derivative.

Tablet

The following are the uses of Bezafibrate 400mg Tablet:

• Used for lowering high cholesterol and triglyceride levels in the blood, reducing the risk of cardiovascular disease.
• Used to treat hyperlipidemia, helping to improve lipid levels and prevent complications.
• Used in the management of mixed lipid disorders, targeting both cholesterol and triglycerides.
• Used to prevent the formation of fatty deposits in blood vessels, reducing the risk of atherosclerosis.
• Used to reduce the risk of heart attacks and strokes in individuals with high lipid levels.
• Used for maintaining healthy lipid levels, especially in those with a family history of lipid disorders.
• Used to support lifestyle changes, such as diet and exercise, for long-term lipid management.

In the case of an overdose of Bezafibrate 400mg Tablets, symptoms may include gastrointestinal disturbances such as nausea, vomiting, and abdominal pain. Additionally, individuals may experience weakness, fatigue, and dizziness. Prompt medical intervention is essential to manage these symptoms effectively. Treatment should focus on supportive care and addressing any specific complications that arise, ensuring the patient's well-being and recovery.

In the case of a missed dose of Bezafibrate 400mg Tablet, it is important to take the medication as soon as you remember. However, if it is almost time for your next scheduled dose, skip the missed dose and continue with your regular dosing schedule. Do not take a double dose to make up for a missed one, as this may increase the risk of side effects. If you frequently miss doses, consider setting reminders or using a pill organizer to help you stay on track with your medication regimen. It is crucial to maintain consistency in taking your medication as prescribed for optimal therapeutic benefits.

To take Bezafibrate 400mg Tablet, swallow the tablet whole with a full glass of water, preferably during a meal or as directed by your healthcare professional, usually once or twice a day, at the same time each day.

Following are the conditions or situations when Bezafibrate 400mg Tablet should not be taken:

• Should not be used in individuals with a known allergy or hypersensitivity to Bezafibrate or any of its excipients.
• Contraindicated in patients with severe liver disease or persistent abnormalities in liver function tests.
• Not recommended for individuals with severe kidney impairment or kidney failure.
• Should not be used in patients with gallstones or a history of gallbladder disease.
• Contraindicated during pregnancy as it may cause harm to the unborn baby.
• Not suitable for breastfeeding mothers as it can pass into breast milk.
• Should be avoided in individuals with severe hypertriglyceridemia (high levels of triglycerides in the blood).
• Not recommended for individuals with a history of pancreatitis (inflammation of the pancreas).
• Should not be used in patients with a history of photosensitivity reactions to fibrates.
• Contraindicated in patients with a history of jaundice or hepatitis during previous fibrate therapy.

The side effects of Bezafibrate 400mg Tablet may include:

• Gastrointestinal issues such as nausea, vomiting, and stomach pain.
• Headaches and dizziness.
• Skin reactions like rash, itching, or hives.
• Weakness and fatigue.
• Muscle pain and joint stiffness.
• Increased sensitivity to sunlight.
• Elevated liver enzymes.
• Allergic reactions in rare cases.

Following are the precautions and warnings for Bezafibrate 400mg Tablet:

• Patients with known hypersensitivity or allergy to Bezafibrate or any of its components should not take this medication.
• Bezafibrate can cause liver problems, so regular monitoring of liver function is necessary. Discontinue use if any signs of liver dysfunction occur.
• This medication may increase the risk of gallstones, and patients with a history of gallbladder disease should be monitored closely.
• Patients with kidney disease should exercise caution and inform their doctor, as dosage adjustments may be required.
• Bezafibrate can increase the risk of muscle problems, especially when used with statins. Inform your doctor if you experience any muscle pain, tenderness, or weakness.
• Elderly patients may be more susceptible to side effects; therefore, close monitoring is advised.
• Pregnant and breastfeeding women should consult their doctor before taking Bezafibrate, as the potential risks and benefits should be carefully considered.
• This medication may cause dizziness or blurred vision; patients should be cautious when performing tasks that require alertness.

Following are the drug interactions for Bezafibrate 400mg Tablet:

• Bezafibrate can increase the effect of anticoagulants like warfarin, leading to an increased risk of bleeding. Regular monitoring of blood clotting parameters is necessary.
• When combined with other fibrates or statins, the risk of muscle-related side effects (e.g., myopathy, rhabdomyolysis) increases. Close monitoring is required.
• The effectiveness of oral contraceptives may be reduced, so alternative or additional contraceptive methods should be considered.
• Corticosteroids can increase the risk of myopathy when used with bezafibrate, requiring close monitoring of muscle enzymes.
• It may increase the blood levels of ciclosporin, necessitating careful monitoring and potential dose adjustment.
• Bezafibrate can interact with antidiabetic medications, affecting blood sugar control. Regular monitoring of blood glucose is essential.
• Certain medications metabolized by the liver, such as warfarin, may have their effects altered, requiring close observation.

Following are the food interactions for Bezafibrate 400mg Tablet:

• Avoid excessive alcohol consumption while taking this medication as it may increase the risk of liver-related side effects and alter the medication's effectiveness.
• Grapefruit and grapefruit juice should be consumed with caution as they can inhibit the metabolism of Bezafibrate, leading to increased blood levels and potential side effects.
• High-fat meals may affect the absorption of Bezafibrate, possibly reducing its effectiveness. It is advisable to take the medication with a consistent meal pattern.
• Avoid high-fat and high-cholesterol foods as Bezafibrate is used to treat high cholesterol, and such foods may counteract the medication's benefits.
• Bezafibrate may increase the risk of gallstone formation, so it's advisable to limit the intake of foods that can trigger gallbladder issues, such as fatty, greasy, or spicy foods.
• Maintain a balanced diet rich in fiber, fruits, and vegetables to support the medication's lipid-lowering effects and overall cardiovascular health.
• Avoid excessive caffeine intake as it may interact with Bezafibrate, potentially causing increased heart rate and blood pressure.
• Always follow the dietary recommendations provided by your healthcare professional to ensure the medication's optimal effectiveness.

Bezafibrate 400mg Tablets should be stored in a secure and dry location, away from direct sunlight, heat, and moisture. The medication container should be tightly sealed to maintain its integrity and effectiveness. It is crucial to keep the tablets out of children's reach to prevent accidental consumption. Do not store the tablets in the bathroom or kitchen cabinets, as these areas can have temperature fluctuations. Always check the expiration date, and if the medication has passed its expiry, do not use it and dispose of it appropriately. When disposing of unused or expired tablets, do not throw them in the trash or pour them down the drain; instead, consult a pharmacist or healthcare professional for guidance on proper disposal methods to ensure environmental safety.

Following are the quick tips for Bezafibrate 400mg Tablet:

• Take the tablet as directed by your doctor, typically once or twice daily with meals.
• Swallow the tablet whole without crushing or chewing for optimal absorption.
• Maintain a consistent schedule for taking the medication for best results.
• Inform your doctor about all medications and supplements you are taking to avoid interactions.
• Avoid alcohol consumption while taking this medication as it may increase side effects.
• Regularly monitor your liver function and blood tests as advised by your doctor.
• Do not stop taking the medication without consulting your doctor to prevent complications.