BI CARZEM SR 120MG IMP CAP (DILTIAZEM)

Diltiazem, the active ingredient in the 120mg capsule, primarily acts as a calcium channel blocker. Its mechanism of action involves selectively inhibiting L-type calcium channels in cardiac and vascular smooth muscle cells. By blocking these channels, diltiazem reduces the influx of calcium ions into these cells, leading to a decrease in myocardial contractility and cardiac conduction velocity. This action results in a lowering of blood pressure by promoting peripheral vasodilation and reducing the heart's workload. Additionally, diltiazem slows the sinoatrial and atrioventricular (SA and AV) nodes' conduction, contributing to its ability to regulate heart rate and rhythm.

Diltiazem 120mg

Calcium channel blocker

Capsule

The following are the uses of Diltiazem 120mg Capsule:

• Used for managing high blood pressure, helping to lower and control hypertension.
• Used for treating chest pain (angina) to reduce the frequency and severity of episodes.
• Used for treating irregular heart rhythms, particularly atrial fibrillation, to restore a normal heart rate.
• Used for improving blood flow in conditions like Raynaud's phenomenon, reducing the occurrence of painful spasms.
• Used for preventing and managing specific types of headaches, particularly cluster headaches.
• Used for managing certain heart conditions like hypertrophic cardiomyopathy to improve heart function.
• Used for reducing blood vessel spasms, especially in conditions related to blood vessel constriction.
• Used for specific types of heart failure, aiding in symptom management and improving cardiac output.

In the case of an overdose of Diltiazem 120mg Capsules, it is important to recognize the potential severity of this situation. Overdosing on this medication can lead to serious health complications, including a significant drop in blood pressure, an irregular heartbeat, and even cardiac arrest. Prompt medical intervention is necessary to manage the symptoms and prevent life-threatening consequences. Seeking emergency medical care is crucial to ensure the best possible outcome in such instances.

In the case of a missed dose of Diltiazem 120mg Capsule, it is important to take the medication as soon as you remember. However, if it is almost time for your next dose, skip the missed dose and continue with your regular dosing schedule. Do not double the dose to make up for a missed one, as this may increase the risk of side effects. If you miss multiple doses, contact your healthcare provider for guidance on how to safely adjust your medication regimen and maintain its effectiveness. It's crucial to take the medication consistently as prescribed to ensure its optimal therapeutic benefit.

To take Diltiazem 120mg Capsule, swallow the capsule whole with a full glass of water, preferably at the same time each day, as directed by your healthcare professional, and do not crush, chew, or break the capsule to maintain its extended-release properties.

Here are the conditions and circumstances when Diltiazem 120mg Capsule should not be taken:

• Avoid if allergic to Diltiazem or other related medications.
• Do not use if you have a severe heart condition, such as AV block (second or third degree) without a pacemaker.
• Contraindicated in individuals with severe low blood pressure or unstable ang.
• Not suitable for patients with a heart rhythm disorder called sick sinus syndrome (without a pacemaker).
• Avoid if you have recently had a heart attack and have certain complications.
• Do not use if you have severe liver disease or impaired liver function.
• Not recommended for individuals with severe kidney disease or those on dialysis.

The side effects of Diltiazem 120mg Capsule may include:

• Dizziness or lightheadedness
• Fatigue and weakness
• Headache
• Nausea and vomiting
• Constipation or diarrhea
• Flushing (reddening of the face)
• Swelling in the lower extremities (legs and ankles)
• Slow heart rate

Following are the precautions and warnings for Diltiazem 120mg Capsule:

• Individuals with a known allergy to Diltiazem or similar medications should not use this capsule.
• Patients with liver or kidney disease should use with caution and under medical supervision as dosage adjustments may be necessary.
• Elderly patients may be more sensitive to the effects and side effects of this medication, requiring careful monitoring.
• Caution is advised when taking this medication with other blood pressure-lowering drugs, as it may cause an excessive drop in blood pressure.
• Patients with heart conditions such as sick sinus syndrome, heart block, or heart failure should use this medication with caution and regular monitoring.
• Diltiazem may affect heart rhythm, so patients with irregular heartbeats or related conditions should be closely monitored.
• This medication can cause dizziness and fatigue; avoid activities requiring mental alertness until you know how it affects you.
• Pregnant and breastfeeding women should consult their doctor before taking this medication as it may have potential risks to the fetus or infant.

Following are the drug interactions for Diltiazem 120mg Capsule:

• Co-administration with beta-blockers can lead to bradycardia and heart block, requiring close monitoring.
• The use of Diltiazem with other calcium channel blockers may result in additive effects and increased risk of hypotension.
• It can interact with digoxin, increasing its blood levels and potential toxicity, so careful monitoring is essential.
• Diltiazem may elevate concentrations of statins, potentially increasing the risk of muscle-related side effects.
• When combined with diuretics, particularly loop diuretics, it can cause excessive blood pressure reduction.
• Caution is advised with CYP3A4 inhibitors like ketoconazole, as they can significantly increase Diltiazem levels, leading to adverse effects.
• The combination with CYP3A4 inducers (e.g., rifampin) may decrease Diltiazem's effectiveness.
• Non-dihydropyridine calcium channel blockers like verapamil, when used with Diltiazem, may cause severe hypotension and bradycardia.

Following are the food interactions to be aware of with Diltiazem 120mg Capsules:

• Grapefruit and grapefruit juice consumption should be avoided as they can increase the levels of Diltiazem in the blood, potentially leading to an increased risk of side effects.
• Alcohol intake should be limited as it may enhance the sedative effects of Diltiazem, causing dizziness or drowsiness.
• Avoid consuming high-fat meals as they can decrease the absorption of Diltiazem, reducing its effectiveness.
• Caffeine-rich foods and beverages might interact with Diltiazem, affecting heart rate and blood pressure.
• Consuming salt substitutes or potassium-rich foods should be monitored as Diltiazem can affect potassium levels in the body.
• Avoid eating or drinking dairy products close to taking Diltiazem, as calcium can interfere with its absorption.
• Herbal supplements like St. John's Wort may reduce Diltiazem levels, so consult your healthcare provider about their use.
• Always follow the dosage instructions provided by your doctor to ensure the medication's effectiveness and minimize potential interactions.

Diltiazem 120mg capsules should be stored in a cool and dry place, preferably at room temperature, ensuring protection from direct sunlight and moisture. Keep the medication in its original container, tightly sealed, to maintain its integrity and prevent contamination. Avoid exposure to extreme temperatures by not storing it in the bathroom or near heat sources like ovens or radiators. Always adhere to the expiration date indicated on the packaging, and if the medication is no longer needed or has expired, proper disposal is crucial. Contact your pharmacist or local waste management authorities for guidance on safe disposal methods, avoiding improper disposal through drains or toilets. It is imperative to keep the medication securely stored and out of the reach of children to prevent accidental consumption.

Following are the quick tips for Diltiazem 120mg Capsule:

• Consult your doctor to determine the correct dosage and duration for your specific condition.
• Swallow the capsule whole with a full glass of water, do not crush or chew.
• Take it at the same time each day to maintain consistent blood levels.
• If you experience dizziness, avoid driving or operating heavy machinery.
• Inform your doctor about all medications you're taking to prevent potential interactions.
• Do not stop taking the medication abruptly without medical advice to prevent complications.
• Store the capsules in a cool, dry place, away from direct sunlight and moisture.
• Regularly monitor your blood pressure and heart rate as advised by your healthcare provider.