bi Preterax (5/1.25mg) 30 Tablets

Perindopril 25mg Tablet, containing the active ingredient perindopril erbumine, primarily exerts its therapeutic effect through the inhibition of the angiotensin-converting enzyme (ACE). ACE is a key component of the renin-angiotensin-aldosterone system (RAAS), which regulates blood pressure and fluid balance in the body. By blocking ACE, perindopril prevents the conversion of angiotensin I to angiotensin II, a potent vasoconstrictor. This inhibition leads to reduced levels of angiotensin II, resulting in vasodilation, decreased vascular resistance, and ultimately, a decrease in blood pressure. Additionally, the reduced angiotensin II levels lead to decreased aldosterone secretion, promoting diuresis and further contributing to blood pressure reduction. The mechanism of action of perindopril is thus focused on modulating the RAAS to achieve its antihypertensive effects.

ACE inhibitor.

Tablet

The following are the uses of perindopril 25mg Tablet:

• Used for treating high blood pressure, helping to prevent heart attacks, strokes, and other cardiovascular issues.
• Used to improve blood flow and reduce strain on the heart.
• Used to treat heart failure, enhancing heart function and reducing symptoms.
• Used to prevent diabetic kidney disease by managing blood pressure.
• Used to reduce the risk of cardiovascular events in patients with stable coronary artery disease.
• Used for long-term management of hypertension, often in combination with other medications.
• Used to improve overall cardiovascular health and quality of life.

In the case of an overdose of perindopril 25mg tablets, it is important to recognize the potential symptoms and seek medical advice promptly. Common signs of overdose may include severe dizziness, extreme low blood pressure, and kidney failure. If you suspect an overdose, contact a healthcare professional or poison control center immediately for guidance. They can provide specific instructions for managing the overdose, which may include inducing vomiting or administering activated charcoal to help absorb the excess medication.

In the case of a missed dose of perindopril 25mg Tablet, it is important to take the medication as soon as you remember. However, if it is almost time for your next dose, skip the missed dose and resume your regular dosing schedule. Do not double the dose to make up for a missed one. If you miss multiple doses, contact your healthcare provider for guidance, as they may advise you to restart the medication or adjust the dosage accordingly. It is crucial to maintain a consistent medication routine to ensure the effectiveness of perindopril in managing your condition.

To take Perindopril 25mg Tablet, swallow the tablet whole with a glass of water, preferably in the morning before a meal, following the dosage instructions provided by your healthcare provider.

Following are the conditions/situations when Perindopril 25mg Tablet should not be used:

• Should not be used in individuals with a known allergy to perindopril or any angiotensin-converting enzyme (ACE) inhibitors.
• Contraindicated in patients with a history of angioedema related to previous ACE inhibitor therapy.
• Not recommended for individuals with severe renal impairment or those on dialysis.
• Should not be used in patients with a narrow aortic or mitral valve stenosis.
• Contraindicated in women who are pregnant or breastfeeding.
• Not suitable for individuals with a history of hereditary angioedema.
• Should be avoided in patients with bilateral renal artery stenosis.

The side effects of perindopril 25mg Tablet may include:

• Dizziness
• Lightheadedness
• Fatigue or weakness
• Cough
• Headache
• Nausea and vomiting
• Diarrhea
• Skin rash or itching

Following are the precautions and warnings for Perindopril 25mg Tablet:

• Patients with a known allergy to perindopril or any other ACE inhibitor should not take this medication.
• Blood pressure should be monitored regularly, especially in the initial stages of treatment.
• Individuals with a history of kidney or liver disease must exercise caution and inform their doctor, as dosage adjustments may be necessary.
• Dehydration or excessive diuretic therapy may increase the risk of low blood pressure; ensure adequate fluid intake.
• Patients with heart disease, especially those with aortic stenosis or hypertrophic cardiomyopathy, should be closely monitored while on this medication.
• Perindopril may cause dizziness or lightheadedness; patients should be cautious when performing tasks that require alertness.
• This medication is not recommended during pregnancy, especially in the second and third trimesters, unless there are no alternatives. Breastfeeding women should also consult their doctor before taking this medication.

Following are the drug interactions for Perindopril 25mg Tablet:

• Potassium-sparing diuretics (e.g., spironolactone, eplerenone) may increase the risk of hyperkalemia when used with perindopril. Regular monitoring of potassium levels is advised.
• Perindopril can enhance the blood pressure-lowering effects of other antihypertensive medications, such as beta-blockers or calcium channel blockers. Close monitoring is required.
• The combination of perindopril with nonsteroidal anti-inflammatory drugs (NSAIDs) may decrease the antihypertensive effect and worsen kidney function.
• Lithium levels may be increased when used with perindopril, potentially leading to lithium toxicity. Monitor lithium levels and adjust dosage as needed.
• Perindopril can increase the risk of angioedema when used with neprilysin inhibitors or angiotensin receptor blockers (ARBs).
• The antihypertensive effect of perindopril may be reduced by nonsteroidal anti-inflammatory drugs (NSAIDs) and corticosteroids.
• When combined with antidiabetic medications, perindopril may cause an increased risk of hypoglycemia. Regular blood glucose monitoring is recommended.
• Perindopril may have additive effects with other medications that affect the renin-angiotensin system, such as aliskiren, potentially leading to renal impairment.

Following are the food interactions for Perindopril 25mg Tablet:

• Avoid excessive potassium-rich foods like bananas, oranges, tomatoes, and spinach, as Perindopril can increase potassium levels in the body.
• Salt substitutes or potassium supplements should be used with caution, as they can lead to high potassium levels.
• Limit alcohol consumption as it can lower blood pressure further and increase the risk of side effects.
• Grapefruit and grapefruit juice should be avoided as they may decrease the breakdown of Perindopril, leading to increased drug levels and potential side effects.
• Maintain a balanced diet, as Perindopril may cause a slight increase in blood sugar levels, especially in diabetic patients.
• Avoid high-sodium foods, as Perindopril is a blood pressure medication, and excessive sodium can counteract its effects.
• Follow a healthy diet low in saturated fats and cholesterol to support overall cardiovascular health while taking Perindopril.

Perindopril 25mg Tablets should be stored in a dry, cool place, preferably at room temperature, ensuring protection from light and moisture. Keep the tablets in their original container, tightly sealed, to maintain their integrity and prevent contamination. Avoid exposing the medication to extreme temperatures by storing it away from heat sources like radiators or stoves. Regularly check the expiration date, and dispose of any unused or expired tablets responsibly. Proper disposal methods should be followed, avoiding flushing or pouring them down the drain. Consult your pharmacist or healthcare professional for guidance on safe disposal practices. Always keep medications out of children's reach to prevent accidental consumption.

Following are the quick tips for Perindopril 25mg Tablet:

• Take the tablet as directed by your doctor, typically once daily.
• Consume the tablet on an empty stomach, preferably in the morning.
• Swallow the tablet whole with a full glass of water, do not crush or chew.
• Maintain a consistent routine by taking it at the same time each day.
• If you experience dizziness, especially when standing up, rise slowly to prevent falls.
• Avoid salt substitutes containing potassium without doctor's advice.
• Regularly monitor your blood pressure and kidney function while on this medication.