Biflocin (500mg) 1 Vial Injection

Flucloxacillin 500mg injection, a semi-synthetic penicillin antibiotic, exerts its bactericidal effect by specifically inhibiting bacterial cell wall synthesis. It targets penicillin-binding proteins (PBPs), particularly those of Gram-positive bacteria, leading to the disruption of cell wall formation. This action is achieved through the binding of flucloxacillin to PBPs, which prevents the cross-linking of peptidoglycan strands, an essential component of the bacterial cell wall. By interfering with cell wall synthesis, flucloxacillin weakens the structural integrity of the bacterial cell, ultimately leading to cell lysis and death. Notably, flucloxacillin is resistant to degradation by beta-lactamases, enzymes produced by some bacteria to confer resistance against beta-lactam antibiotics, thus maintaining its effectiveness against a range of penicillinase-producing organisms.

Flucloxacillin 500mg

Penicillin antibiotic

Injection

The following are the uses of Flucloxacillin 500mg injection:

• Used for treating serious bacterial infections such as pneumonia, bone and joint infections, and skin and soft tissue infections.
• Used for its effectiveness against a range of bacteria, particularly penicillinase-producing staphylococci.
• Used for intravenous treatment when oral administration is not possible or less effective.
• Used as a first-line antibiotic in severe infections requiring prompt intervention.
• Used for its ability to penetrate well into various body tissues and fluids.
• Used for patients with a known sensitivity to penicillin, providing an alternative treatment option.

In the case of an overdose of Flucloxacillin 500mg injection, it is important to seek medical advice promptly. Overdose symptoms may include gastrointestinal disturbances, such as nausea, vomiting, and diarrhea, as well as potential liver or kidney issues. Prompt medical intervention can help manage these symptoms and ensure appropriate treatment to mitigate any adverse effects. Monitoring and supportive care are essential components of managing a Flucloxacillin overdose.

In the case of a missed dose of Flucloxacillin 500mg injection, it is important to administer the missed dose as soon as you remember. If it is almost time for your next scheduled dose, skip the missed dose and continue with your regular dosing schedule. Do not double the dose to make up for a missed one. If you miss multiple doses, contact your healthcare provider for advice on how to proceed, as they may recommend adjusting your dosing schedule to ensure the medication's effectiveness. It is crucial to maintain a consistent medication routine for optimal results.

To administer Flucloxacillin 500mg injection, ensure the injection site is clean, insert the needle at a 90-degree angle, and slowly inject the prescribed dosage as directed by your healthcare provider, typically given intramuscularly or intravenously, following the recommended administration schedule.

Here are the conditions or situations when Flucloxacillin 500mg injection should not be used:

• Must not be used in individuals with a confirmed or suspected allergy to penicillin or any other β-lactam antibiotic.
• Contraindicated in patients with a history of severe allergic reactions to any other class of antibiotics.
• Should not be used if the patient has shown immediate hypersensitivity to flucloxacillin or any other penicillin-type antibiotics in the past.
• Not recommended for individuals with severe liver impairment or active liver disease.
• Avoid using in patients with a history of cholestatic jaundice/hepatic dysfunction associated with flucloxacillin.
• Not suitable for long-term use, and prolonged use may lead to the development of antibiotic-resistant bacteria.
• Exercise caution in patients with kidney disease or those on dialysis, and dosage adjustments may be required.

The side effects of Flucloxacillin 500mg injection may include:

• Skin rash or itching
• Nausea and vomiting
• Diarrhea
• Abdominal pain
• Allergic reactions (such as hives, swelling, or difficulty breathing)
• Liver problems (e.g., jaundice, dark urine)
• Joint pain or swelling
• Thrombocytopenia (low platelet count)

Following are the precautions and warnings:

• Flucloxacillin 500mg injection should not be administered to individuals with a known allergy to penicillin-type medications or any ingredients in the injection.
• This medication must be used with caution in patients with a history of kidney or liver disease, as dosage adjustments may be necessary.
• Prolonged use may lead to the overgrowth of non-susceptible organisms, including fungi, so regular monitoring is essential.
• Patients should be advised to complete the full course of treatment, even if they feel better before the medication is finished.
• Caution is advised for patients with a history of gastrointestinal disease, particularly colitis, as Flucloxacillin may cause gastrointestinal side effects.
• It should be used with care in individuals with a history of allergies or asthma, as severe allergic reactions may occur.
• Pregnant and breastfeeding women should consult their healthcare professional before using this medication, as it may pass into breast milk.
• Flucloxacillin may cause false-positive results in certain urine glucose tests, so patients should inform their doctor if they are undergoing such tests.

Following are the drug interactions for Flucloxacillin 500mg injection:

• Increases the risk of Flucloxacillin-related side effects by reducing its excretion.
• May enhance the anticoagulant effect, requiring close monitoring of prothrombin time.
• Can reduce its excretion, potentially leading to increased toxicity.
• May result in antagonism of the bactericidal effects of both drugs.
• Flucloxacillin can reduce the efficacy of oral contraceptives, requiring additional contraceptive measures.
• Possible increased risk of seizures when used together.
• Can increase the risk of side effects due to elevated tizanidine levels.

Following are the food interactions for Flucloxacillin 500mg injection:

• Avoid excessive alcohol consumption during the treatment period as it may increase the risk of liver-related side effects.
• Grapefruit and grapefruit juice should be consumed with caution as they can affect the metabolism of Flucloxacillin, potentially leading to increased drug levels in the body.
• Maintain a balanced diet to support overall health and ensure the medication's effectiveness.
• Avoid high-fat meals as they may slow down the absorption of Flucloxacillin, delaying its therapeutic effect.
• Ensure adequate fluid intake to prevent dehydration, especially if experiencing diarrhea as a side effect.
• Avoid consuming dairy products if diarrhea occurs, as lactose intolerance can be a potential side effect of antibiotic use.
• Flucloxacillin can be taken with or without food, but it is generally recommended to take it with a full glass of water to aid in absorption.
• Consult your healthcare provider or pharmacist for specific dietary recommendations based on your medical history and condition.

Flucloxacillin 500mg injection should be stored in a controlled environment, preferably between 68°F and 77°F (20°C and 25°C), away from excessive heat and moisture. Protect the injection from direct sunlight and ensure it is stored in its original packaging to maintain its integrity. It is crucial to adhere to the expiration date printed on the packaging and discard any unused or expired medication responsibly. Avoid flushing or pouring the injection down the drain; instead, seek guidance from a pharmacist or healthcare professional for appropriate disposal methods. Keep the injection out of children's reach to prevent accidental exposure.

Following are the quick tips for Flucloxacillin 500mg injection:

• Administer the injection as directed by your healthcare professional.
• Ensure the injection is prepared and administered by a trained healthcare provider.
• Injection site should be cleaned and disinfected before administration.
• Rotate injection sites to minimize discomfort and tissue damage.
• Do not reuse needles or syringes; dispose of them safely after use.
• Report any signs of allergic reaction or severe side effects immediately.
• Store the injection as directed on the packaging, away from direct sunlight.