BIPOL D 3/25MG TAB

The combination of Olanzapine 3mg and Fluoxetine 25mg in a single tablet has a synergistic effect on treating depression and other psychiatric disorders. Olanzapine, a second-generation antipsychotic, primarily acts as a dopamine and serotonin antagonist, blocking specific receptors in the brain, particularly the serotonin 5-HT2A and dopamine D2 receptors. This blockade results in reduced psychotic symptoms and improved mood stabilization. Fluoxetine, a selective serotonin reuptake inhibitor (SSRI), increases serotonin levels in the brain by inhibiting its reabsorption, thus enhancing neurotransmission and regulating mood. Together, these mechanisms work to alleviate symptoms of depression, particularly when depression is accompanied by psychotic features or mood disorders with mixed symptoms. This combination therapy may be particularly effective in patients with treatment-resistant depression or those experiencing both depressive and psychotic symptoms.

Antipsychotic, Antidepressant.

Tablet

The following are the uses of Olanzapine 3mg, Fluoxetine 25mg Tablet:

• Used for treating bipolar disorder, helping to stabilize mood swings and reduce manic episodes.
• Used for managing schizophrenia, aiding in controlling hallucinations and delusions.
• Used to treat severe depression, especially when combined with fluoxetine, to improve mood and energy levels.
• Used for controlling anxiety and promoting relaxation in patients with anxiety disorders.
• Used to assist in reducing obsessive thoughts and compulsive behaviors in OCD patients.
• Used for managing eating disorders, such as binge eating, by helping control impulsive behaviors.
• Used to aid in the treatment of certain personality disorders, improving emotional regulation.

In the case of an overdose of Olanzapine 3mg and Fluoxetine 25mg Tablet, individuals may experience a range of symptoms including severe drowsiness, rapid heartbeat, confusion, seizures, and difficulty breathing. It is important to seek immediate medical assistance and inform healthcare professionals about the medications involved. Prompt action can help manage potential complications and ensure appropriate treatment to address the overdose.

In the case of a missed dose of Olanzapine 3mg, it is generally recommended to take the missed dose as soon as you remember, but if it is close to the time for your next scheduled dose, skip the missed dose and continue with your regular dosing schedule. For Fluoxetine 25mg Tablet, if a dose is missed, take it as soon as you remember, but if it is within 6 hours of the next dose, skip the missed dose and continue with your regular dosing schedule. Do not double the dose to make up for a missed one.

To take Olanzapine 3mg and Fluoxetine 25mg tablets, swallow the tablets whole with a glass of water, preferably at the same time each day, following the dosage instructions provided by your healthcare professional.

Following are the conditions/situations when Olanzapine 3mg, Fluoxetine 25mg Tablet should not be taken:

• Allergic reaction Do not take this medication if you have a known allergy to Olanzapine, Fluoxetine, or any other similar antidepressant or antipsychotic medications.
• Liver problems It is contraindicated in patients with severe liver impairment or liver disease.
• Uncontrolled seizures Do not use if you have a history of seizures that are not well-controlled.
• Monoamine Oxidase Inhibitors (MAOIs) Do not take this medication if you are currently using MAOIs or have used them within the last 14 days.
• Glaucoma Olanzapine-Fluoxetine combination should be used with caution in patients with narrow-angle glaucoma.
• Thrombocytopenia Not recommended for individuals with low platelet count.

The side effects of Olanzapine 3mg, Fluoxetine 25mg Tablet may include:

• Increased appetite and weight gain
• Drowsiness or sleepiness
• Dry mouth
• Constipation
• Dizziness
• Restlessness or agitation
• Blurred vision
• Muscle stiffness or tremors

Following are the precautions and warnings:

• Olanzapine and Fluoxetine combination should be used with caution in patients with a history of seizures or conditions that lower the seizure threshold, as it may increase the risk of seizures.
• Patients with cardiovascular disease or risk factors should be monitored regularly as this medication can cause changes in heart rate and blood pressure.
• It is important to monitor blood sugar levels in diabetic patients as olanzapine can increase the risk of hyperglycemia.
• This medication may cause weight gain, so regular weight monitoring is advised, especially in patients with a history of weight-related issues.
• Fluoxetine may increase the risk of bleeding, especially when combined with other medications affecting bleeding, and should be used with caution in patients with bleeding disorders.
• Elderly patients may be more sensitive to the side effects of this medication, particularly olanzapine-induced adverse effects.
• Patients should be advised to avoid alcohol consumption as it may increase the risk of side effects and impair judgment.
• Olanzapine can cause extrapyramidal symptoms; patients should be monitored for any unusual movements or muscle stiffness.

Following are the drug interactions for Olanzapine 3mg, Fluoxetine 25mg Tablet:

• Alcohol and central nervous system (CNS) depressants (e.g., benzodiazepines, opioids) may increase sedation and respiratory depression, requiring dosage adjustments.
• Serotonergic drugs (e.g., other antidepressants, triptans, tramadol) can lead to serotonin syndrome, a potentially life-threatening condition.
• Monoamine oxidase inhibitors (MAOIs) should not be used concurrently or within 14 days of discontinuing Olanzapine/Fluoxetine due to the risk of serious reactions.
• Fluoxetine is a strong inhibitor of CYP2D6, affecting the metabolism of drugs like tricyclic antidepressants and antipsychotics.
• Drugs metabolized by CYP1A2 (e.g., theophylline, caffeine) may have increased plasma levels when used with Fluoxetine.
• Anticoagulants (e.g., warfarin) may have enhanced effects, requiring close monitoring of coagulation parameters.
• Olanzapine may increase the risk of hyperglycemia and diabetes, especially with other medications that affect glucose metabolism.

Following are the food interactions for Olanzapine 3mg, Fluoxetine 25mg Tablet:

• Avoid alcohol consumption as it can increase the sedative effects of Olanzapine, leading to enhanced drowsiness and dizziness.
• Grapefruit and grapefruit juice should be consumed cautiously as they may affect the metabolism of Fluoxetine, potentially increasing its levels in the blood and the risk of side effects.
• High-fat meals can decrease the absorption of Fluoxetine, so it is recommended to avoid high-fat foods around the time of medication intake.
• Caffeine intake should be monitored as Olanzapine may increase its sensitivity, potentially leading to increased side effects like nervousness and rapid heartbeat.
• Avoid herbal products like St. John's Wort, as it can interfere with Fluoxetine's effectiveness and increase the risk of serotonin syndrome.
• Maintain a consistent intake of Vitamin B6 and folate-rich foods, as Olanzapine may lower their levels, which are essential for overall health.
• Avoid excessive tyramine-rich foods (aged cheeses, cured meats) as Fluoxetine can potentially interact, leading to increased blood pressure.
• Consult your healthcare provider for personalized advice on diet and medication interactions.

Olanzapine 3mg, Fluoxetine 25mg tablets should be stored in a cool and dry place, preferably in their original container, ensuring the bottle is tightly sealed. It is crucial to keep the medication away from direct sunlight, moisture, and extreme temperatures. Avoid storing it in bathrooms or kitchen cabinets near heat-emitting appliances. Regularly check the expiration date, and dispose of any expired or unused tablets promptly. When disposing of the medication, do not flush it down the toilet or sink; instead, follow local guidelines or consult a pharmacist for safe disposal methods. Keep the tablets out of children's reach to prevent accidental consumption.

Following are the quick tips for Olanzapine 3mg, Fluoxetine 25mg Tablet:

• Take the tablet as directed by your doctor, typically once daily.
• Swallow the tablet whole with a full glass of water, do not crush or chew.
• Maintain a consistent daily routine for medication intake.
• It can be taken with or without food, but taking it with food may prevent stomach upset.
• Avoid alcohol consumption while on this medication.
• Do not stop the medication without consulting your doctor, even if you feel better.
• Store the tablets in a cool, dry place, away from direct sunlight.