Bistolic (10Mg) 10 Tablet

Nebivolol, the active ingredient in Nebivolol 10mg Tablets, is a beta-adrenergic blocking agent, commonly known as a beta-blocker. Its primary mechanism of action involves selective beta-1 receptor blockade in the heart, which reduces the heart rate and decreases the force of contraction. By blocking beta-1 receptors, Nebivolol inhibits the effects of catecholamines like adrenaline, leading to a decrease in cardiac output and blood pressure. This action helps in the management of hypertension and certain cardiovascular conditions. Nebivolol also exhibits vasodilatory properties by enhancing the release of nitric oxide, which contributes to its overall effectiveness in lowering blood pressure and improving cardiovascular function.

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Beta-blocker

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Tablet

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The following are the uses of Nebivolol 10mg Tablet:

• Used for treating high blood pressure, helping to lower and control hypertension.
• Used to manage and relieve symptoms of heart failure, improving heart function.
• Used to reduce the risk of cardiovascular events, such as stroke or heart attack, in patients with a history of these conditions.
• Used to alleviate chest pain (angina) by improving blood flow to the heart.
• Used to enhance exercise capacity in patients with cardiovascular issues.
• Used to reduce the workload on the heart, promoting better overall heart health.
• Used to potentially slow the progression of certain heart-related conditions.

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Dose must be taken according to the doctor’s advice only; doses given below are suggested as supportive literature for better understanding in some areas of requirements. Adult Dose: Not recommended in age below 18 years. Adult dose: Starting is 2.5mg/day, then 5-40mg once daily. In patients over 65 years of age, the starting dose is 2.5mg daily, if required then the daily dose may be increased to 5mg. In patients of chronic heart failure, along with the use of other drugs like; diuretics and/or digoxin and/or ACE inhibitors and/or angiotensin II antagonists, the dose of these drugs and nebivolol must be adjusted accordingly, with initial dose of nebivolol as 1.25mg daily to 2.5mg and then to 5mg per day and then 10mg per day at intervals of 1-2 weeks based on patient’s tolerability.

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In the case of an overdose of Nebivolol 10mg Tablets, several symptoms may manifest. The patient could experience a significant drop in blood pressure, leading to lightheadedness, dizziness, and even fainting. Additionally, an overdose may cause an abnormally slow heart rate, which can result in fatigue, weakness, and difficulty breathing. It is imperative to seek immediate medical assistance if an overdose is suspected, as prompt treatment can mitigate these potentially severe effects.

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In the case of a missed dose of Nebivolol 10mg Tablet, it is important to take the medication as soon as you remember. If it is almost time for your next scheduled dose, skip the missed dose and continue with your regular dosing schedule. Do not double the dose to make up for a missed one, as this may increase the risk of side effects. It is advisable to set a daily routine to help you remember to take your medication at the same time each day. If you frequently miss doses, consider setting an alarm or asking a family member to remind you.

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To take Nebivolol 10mg Tablet, swallow the tablet whole with a glass of water, preferably at the same time each day, following the dosage instructions provided by your healthcare professional, without crushing or chewing the tablet.

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Following are the conditions or circumstances when Nebivolol 10mg Tablet should not be taken:

• Nebivolol 10mg Tablet should not be used in patients with a known allergy or hypersensitivity to Nebivolol or any of the excipients in the tablet.
• Contraindicated in patients with severe bradycardia (very slow heart rate).
• Should not be given to patients with cardiogenic shock (a critical condition where the heart cannot pump enough blood).
• Not recommended for individuals with severe hepatic impairment (severe liver problems).
• Avoid in patients with decompensated heart failure, as it may worsen the condition.
• Do not use in patients with sick sinus syndrome (a type of heart rhythm problem).
• Contraindicated in patients with severe peripheral arterial disease.
• Not suitable for individuals with untreated pheochromocytoma (a rare tumor of the adrenal gland).

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The side effects of Nebivolol 10mg Tablet may include:

• Fatigue and weakness
• Dizziness or lightheadedness
• Headache
• Slow heart rate (bradycardia)
• Nausea and vomiting
• Diarrhea
• Sleep disturbances
• Cold extremities

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Following are the precautions and warnings for Nebivolol 10mg Tablet:

• Do not abruptly stop taking this medication, as it may lead to a sudden worsening of your condition. Consult your doctor for a proper tapering plan.
• Nebivolol can cause dizziness and lightheadedness, especially when standing up from a sitting or lying position. Be cautious and avoid driving or operating heavy machinery until you know how the medication affects you.
• This medication may mask the symptoms of low blood sugar, especially in diabetics. Monitor blood glucose levels regularly.
• Patients with a history of lung diseases like asthma or chronic obstructive pulmonary disease (COPD) should use Nebivolol with caution, as it may worsen these conditions.
• It may cause a decrease in heart rate. Seek medical attention if you experience unusual fatigue, shortness of breath, or fainting.
• Pregnant or breastfeeding women should consult their doctor before taking Nebivolol, as it may have potential risks for the fetus or infant.
• Inform your healthcare provider about all the medications you are currently taking to avoid potential drug interactions.

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Following are the drug interactions for Nebivolol 10mg Tablet:

• Drugs that block the action of beta-blockers, such as clonidine, may lead to increased blood pressure when stopping the drug.
• Rifampicin can reduce the effect of nebivolol.
• Caution with general anesthetics as nebivolol may reduce heart rate and blood pressure.
• NSAIDs and corticosteroids may reduce the antihypertensive effect of nebivolol.
• CYP2D6 inhibitors like fluoxetine may increase nebivolol levels.
• Nebivolol may increase the blood levels of CYP2D6 substrates like paroxetine.
• Alcohol may enhance the blood pressure-lowering effect of nebivolol.

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Following are the food interactions for Nebivolol 10mg Tablet:

• Avoid consuming large amounts of grapefruit or grapefruit juice as it can increase blood levels of Nebivolol, potentially leading to an increased risk of side effects.
• Alcohol consumption should be limited or avoided as it may reduce the effectiveness of Nebivolol and lead to reduced blood pressure control.
• Caffeine intake should be monitored as it can reduce the blood pressure-lowering effect of Nebivolol, especially in high doses.
• Salt and sodium-rich foods should be limited as Nebivolol's effectiveness in controlling blood pressure can be hindered by a high-sodium diet.
• Potassium-rich foods like bananas, oranges, and spinach are beneficial as Nebivolol may lower potassium levels, and maintaining a balanced diet can help manage this.
• Licorice should be avoided as it can decrease the effectiveness of Nebivolol and potentially lead to increased blood pressure.
• A balanced and healthy diet is recommended to support overall cardiovascular health while taking Nebivolol.
• Always consult your healthcare provider for personalized dietary advice and any specific food restrictions related to your medication.

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Nebivolol 10mg Tablets should be stored in a cool and dry place, preferably at room temperature, ensuring protection from direct sunlight and moisture. Keep the tablets in their original container, tightly sealed, to maintain their integrity and prevent exposure to external elements. It is crucial not to store them in the bathroom or near heat-emitting appliances to avoid potential degradation. Regularly check the expiration date, and if the tablets are no longer needed or have expired, proper disposal is essential. Do not dispose of them in household waste or pour them down the drain; instead, follow local guidelines or consult a pharmacist for safe disposal methods. Keep this medication securely stored, out of the reach of children, to prevent accidental consumption.

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Following are the quick tips for Nebivolol 10mg Tablet:

• Take the tablet at the same time each day to maintain consistent blood levels.
• Swallow the tablet whole with a glass of water, do not crush or chew.
• Take the medicine as prescribed, do not stop without consulting your doctor.
• Avoid alcohol consumption as it may increase side effects.
• Inform your doctor about all medications you're taking to prevent interactions.
• Store the tablets in a cool, dry place, away from direct sunlight.
• Do not share this medication with others; it is prescribed specifically for your condition.
• Regularly monitor your blood pressure and heart rate while on this medication.

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Keep on monitoring your Blood Pressure with use. To monitor heart health, go for; ECG

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