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Bistolic (5mg) 10 Tablets
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- Manufacturer McOLSON Research Laboratories (Pvt.) Ltd.
- Generic Name Nebivolol
Healthwire Pharmacy Ratings & Reviews (1500+)
4.9/
5
Rs. 18.0
Rs. 20.0
10% OFF
Delivery by Today, 04:00 pm - 07:00 pm
Product Information
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Description
Antihypertensive; Selective Beta-1 Blocker. (Nebivolol) is a highly selective beta-1 adrenergic receptor antagonist drug It has weak beta-2 adrenergic receptor antagonist activity. When d-nebivolol blocks beta-1 adrenergic, then it results in decreased resting heart rate, myocardial contractility, exercise heart rate, systolic blood pressure, and diastolic blood pressure. The selectivity of d-nebivolol limits the magnitude of beta blocker adverse effects in the airways or relating to insulin sensitivity. (Nebivolol) inhibits aldosterone, and antagonizes beta-1 receptors in the juxtaglomerular apparatus and inhibits the renin release. When aldosterone decreases then blood volume also decreases, and decreased renin results in reduced vasoconstriction. l-nebivolol shows beta-3 adrenergic receptor agonist activity that promotes endothelial nitric oxide synthase, enhances nitric oxide levels; resulting in vasodilation, reduced peripheral vascular resistance, increased stroke volume, ejection fraction, and cardiac output. (Nebivolol) benefits heart failure patients by reducing oxidative stress, decreasing platelet volume and aggregation. -
Ingredients
Nebivolol -
Dosage Form
Tablet -
Uses
Hypertension (High Blood Pressure) -
Dosage
Dose must be taken according to the doctor’s advice only; doses given below are suggested as supportive literature for better understanding in some areas of requirements. Adult Dose: Not recommended in age below 18 years. Adult dose: Starting is 2.5mg/day, then 5-40mg once daily. In patients over 65 years of age, the starting dose is 2.5mg daily, if required then the daily dose may be increased to 5mg. In patients of chronic heart failure, along with the use of other drugs like; diuretics and/or digoxin and/or ACE inhibitors and/or angiotensin II antagonists, the dose of these drugs and nebivolol must be adjusted accordingly, with initial dose of nebivolol as 1.25mg daily to 2.5mg and then to 5mg per day and then 10mg per day at intervals of 1-2 weeks based on patient’s tolerability. -
In case of Overdose
It’s overdose can cause blurred vision, hypotension, uneven heart beat consult your doctor in case of overdose. -
Missed Dose
In case you missed any dose, take the next dose as soon as you remember, but don't double your next dose to compensate for the missed one. -
How To Use
Take orally as instructed by the physician. -
When Not to Use
Hypersensitivity to (Nebivolol) or any component of the formulation, severe bradycardia, heart block greater than first-degree (except in patients with a functioning artificial pacemaker), cardiogenic shock, decompensated heart failure, sick sinus syndrome (unless a permanent pacemaker is in place), severe hepatic impairment, Severe peripheral arterial circulatory disorders, sinoatrial block, rare hereditary conditions of Galactose intolerance, congenital lactase deficiency or glucose-galactose malabsorption. -
Side Effects
Peripheral edema Bradycardia Chest pain Headache Fatigue (dose-related) Dizziness Insomnia Paresthesia Skin rash Decreased HDL cholesterol Hypercholesterolemia Increased serum triglycerides Increased uric acid Diarrhea Nausea Abdominal pain Decreased platelet count Erectile dysfunction -
Precautions & Warnings
Exposure to beta-blockers during pregnancy may increase the risk for adverse events in the neonate. Chronic maternal hypertension may increase the risk of birth defects, low birth weight, premature delivery, stillbirth, and neonatal death. Untreated chronic hypertension may also increase the risks of adverse maternal outcomes, including gestational diabetes, preeclampsia, delivery complications, stroke, and myocardial infarction so consult the doctor for proper management and treatment of hypertension during pregnancy. (Nebivolol) may cause harmful effects on pregnancy and may harm fetus/newborn. As a beta-adrenoceptor blockers this drug may reduce placental perfusion, which has been linked with growth retardation, intrauterine death, abortion or early labour. -
Food Interactions
Avoid the use of potassium rich diet along with this medicine because, potassium-rich foods when taken along with nebivolol can result in high potassium levels in the blood. -
Storage/Disposal
Store at 25°C Protect from sunlight and moisture.
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