BIVALEK SPRAY

The combination of Neomycin and Bacitracin in the spray formulation exhibits a synergistic mechanism of action to combat bacterial infections. Neomycin, an aminoglycoside antibiotic, binds to specific proteins on the bacterial cell membrane, disrupting its function and leading to bacterial cell death. It primarily targets Gram-negative bacteria. Bacitracin, a polypeptide antibiotic, inhibits cell wall synthesis in susceptible bacteria by interfering with the transport of peptidoglycan precursors. This prevents the formation of new cell walls, thereby halting bacterial growth and replication. Together, these antibiotics provide broad-spectrum coverage against a wide range of bacteria, including both Gram-positive and Gram-negative organisms, making the spray effective for treating superficial skin and mucosal infections.

Aminoglycoside/Polypeptide Antibiotics

Spray

The following are the uses of Neomycin 165000IU, Bacitracin 12500IU Spary:

• Used for treating bacterial skin infections, including impetigo, cellulitis, and wound infections.
• Used for preventing infection in minor cuts, scrapes, burns, and post-surgical wounds.
• Used for reducing the risk of infection in minor skin injuries.
• Used for promoting healing and preventing bacterial growth in skin conditions.
• Used for managing skin infections in patients with compromised immune systems.
• Used for adjunctive therapy in skin infections alongside other systemic antibiotics.
• Used for preventing infection in skin grafts and donor sites.

In the case of an overdose of Neomycin 165000IU and Bacitracin 12500IU Spray, symptoms may include nausea, vomiting, dizziness, and hearing loss. The severity of these symptoms can vary depending on the amount ingested. If an overdose is suspected, immediate medical attention is required. Treatment may involve managing symptoms and providing supportive care to address any potential hearing or kidney damage associated with Neomycin toxicity. Prompt action can help mitigate the risks associated with overdosing on this medication.

In the case of a missed dose of Neomycin 165000IU and Bacitracin 12500IU Spray, it is recommended to administer the missed dose as soon as you remember. However, if it is almost time for your next scheduled dose, skip the missed dose and continue with your regular dosing schedule. Do not double the dose to make up for a missed one. If you miss multiple doses, contact your healthcare provider for further guidance on how to resume your medication regimen safely.

To use Neomycin 165000IU, Bacitracin 12500IU Spray, gently shake the bottle, spray the prescribed number of pumps directly into the throat as directed by your healthcare provider, and follow the recommended dosage instructions provided by your doctor or as indicated on the product label.

Here are the conditions or situations when Neomycin 165000IU, Bacitracin 12500IU Spray should not be used:

• Do not use if you have a known allergy or hypersensitivity to Neomycin, Bacitracin, or any other ingredients in the spray.
• Avoid using this spray if you have a history of hearing loss or balance disorders (vestibular toxicity) associated with the use of these antibiotics.
• Not suitable for individuals with kidney disease or dysfunction.
• Do not use if you have a perforated eardrum or a damaged tympanic membrane.
• Contraindicated in patients with a history of myasthenia gravis.
• Should not be used if you have a skin condition called Eczema.
• Avoid using this spray if you have a known or suspected bacterial infection that is not responsive to the antibiotics in the spray.

The side effects of Neomycin 165000IU, Bacitracin 12500IU Spray may include:

• Skin irritation or rash at the application site
• Itching or redness
• Allergic reactions, such as hives or swelling
• Hearing loss or ringing in the ears (tinnitus)
• Dizziness or balance problems
• Kidney issues, including kidney damage with long-term use
• Numbness or tingling in the extremities

Following are the precautions and warnings for Neomycin 165000IU, Bacitracin 12500IU Spray:

• Avoid using this medication if you have a known allergy to Neomycin, Bacitracin, or any other ingredients in the spray.
• Do not use this spray for extended periods without medical supervision, as prolonged use may lead to bacterial resistance or hearing issues.
• If you have pre-existing kidney problems, use with caution and under medical advice, as Neomycin can be potentially harmful to the kidneys.
• Avoid contact with eyes. If accidental contact occurs, rinse thoroughly with water.
• Do not use this spray if you have a perforated eardrum or ear pain; consult a healthcare professional for proper diagnosis and treatment.
• Keep out of reach of children. Store in a cool, dry place, away from direct sunlight.
• If symptoms persist or worsen, discontinue use and seek medical attention immediately.
• Inform your doctor if you are pregnant, planning to become pregnant, or breastfeeding before using this medication.

Following are the drug interactions for Neomycin 165000IU, Bacitracin 12500IU Spray:

• Ototoxic medications like furosemide or gentamicin may increase the risk of hearing impairment when used with neomycin.
• Neomycin can reduce the absorption of oral medications like levothyroxine, requiring careful monitoring of blood levels.
• The effects of neuromuscular blocking agents, such as succinylcholine, can be prolonged by neomycin, leading to respiratory issues.
• Bacitracin may reduce the effectiveness of tetracycline antibiotics, so separate administration by at least 2 hours.
• Avoid using other topical antibiotics or antiseptics without medical advice, as it may increase the risk of skin reactions.
• Anticoagulants like heparin might have enhanced effects when used with bacitracin, requiring close monitoring for bleeding.
• Neomycin may interact with live vaccines, potentially reducing their effectiveness.

Following are the food interactions for Neomycin 165000IU, Bacitracin 12500IU Spray:

• Avoid consuming dairy products like milk, cheese, and yogurt, as they may interact with Neomycin, reducing its effectiveness.
• Grapefruit and grapefruit juice should be avoided as they can interfere with the absorption of the medication.
• Alcohol consumption should be minimized or avoided as it may increase the risk of side effects and slow down the healing process.
• Avoid sugary foods and beverages, as high sugar intake can promote bacterial growth and delay wound healing.
• Consume a balanced diet rich in protein, vitamins, and minerals to support the body's healing process.
• Stay well-hydrated by drinking plenty of water to maintain oral health and aid in the recovery process.
• Avoid spicy foods, as they may irritate the treated area and cause discomfort.
• Follow any dietary instructions provided by your healthcare professional for optimal healing.

Neomycin 165000IU, Bacitracin 12500IU Spray should be stored in a cool and dry place, preferably at room temperature, ensuring protection from direct sunlight and moisture. The spray bottle should be tightly sealed to maintain its integrity and prevent contamination. It is crucial to keep this medication away from heat sources like radiators or stoves, as temperature fluctuations can impact its effectiveness. Always check the expiration date, and if the spray has passed its expiry, proper disposal is essential. Avoid pouring it down the drain or flushing it; instead, consult a pharmacist for guidance on safe disposal methods. Keep the spray out of children's reach to prevent accidental exposure.

Following are the quick tips for Neomycin 165000IU, Bacitracin 12500IU Spray:

• Ensure you follow the dosage instructions provided by your healthcare professional.
• Before each use, gently shake the spray bottle to mix the solution well.
• Aim the spray at the affected area and administer the prescribed number of sprays.
• Maintain a consistent daily routine for applying the spray for best results.
• Avoid getting the spray in your eyes; if contact occurs, rinse thoroughly with water.
• Store the spray at room temperature, away from direct sunlight and moisture.
• Always replace the cap securely after use to prevent contamination.