Blephapred (10/0.2/0.12%) 5ml Eye Suspension

Phenylephrine, a sympathomimetic amine, acts as a selective alpha-1 adrenergic receptor agonist, causing vasoconstriction of the conjunctival and episcleral blood vessels, thereby reducing redness and inflammation in the eye. Sulphacetamide, a sulfonamide antibiotic, exerts its action by inhibiting the synthesis of folic acid in susceptible bacteria, primarily targeting the conjunctival sac and eyelids. Prednisolone and prednisone are corticosteroids that possess potent anti-inflammatory properties. They bind to cytoplasmic glucocorticoid receptors, influencing gene expression and suppressing the release of inflammatory mediators, leading to a reduction in ocular inflammation and associated symptoms.

Ophthalmic anti-inflammatory and decongestant.

Drop

The following are the uses of Phenylephrine, Sulphacetamide, Prednisolone and Prednisone Eye Syrup/Suspension:

• Used for reducing inflammation and redness in the eye, often due to allergies or irritation.
• Used to relieve eye itching and discomfort caused by allergic conjunctivitis.
• Helps to constrict blood vessels in the eye, reducing redness and swelling.
• Effective in treating bacterial eye infections, preventing their spread.
• Provides relief from eye pain and sensitivity to light.
• Aids in managing inflammatory eye conditions such as uveitis and keratitis.
• Used post-eye surgery to aid healing and prevent infection.
• Can be prescribed for long-term management of chronic eye conditions.

In the case of an overdose of Phenylephrine, Sulphacetamide, Prednisolone, and Prednisone Eye Syrup/Suspension, individuals may experience increased eye pressure, redness, and irritation. Symptoms could also include nausea, dizziness, and headaches. Immediate medical attention is necessary, as healthcare professionals can provide appropriate treatment and support to manage the effects of the overdose and prevent further complications.

In the case of a missed dose of Phenylephrine, Sulphacetamide, Prednisolone, and Prednisone Eye Syrup/Suspension, it is recommended to administer the missed dose as soon as you remember. However, if it is almost time for the next dose, skip the missed dose and continue with your regular dosing schedule. Do not double the dose to make up for a missed one. If you miss multiple doses, contact your healthcare provider for guidance on how to proceed with your medication regimen.

To administer the Phenylephrine, Sulphacetamide, Prednisolone, and Prednisone Eye Syrup/Suspension, gently shake the bottle well, ensuring it is properly mixed, then use the provided dropper or dosing device to measure the prescribed amount, administering the medication directly into the eye as directed by your healthcare provider, typically a few times a day, following the recommended dosage and treatment duration.

Here are the conditions or situations when Phenylephrine, Sulphacetamide, Prednisolone, and Prednisone Eye Syrup/Suspension should not be used:

• Do not use if you have a known allergy or hypersensitivity to any of the active ingredients (Phenylephrine, Sulphacetamide, Prednisolone, or Prednisone) or any of the excipients in the eye syrup/suspension.
• Avoid using this medication if you have a fungal, viral, or mycobacterial infection in the eye(s).
• Not suitable for individuals with a history of recent ocular surgery or trauma.
• Should not be used if you have a herpes simplex infection of the eye.
• Contraindicated in patients with glaucoma or those who are at risk of developing glaucoma.
• Not recommended for individuals with a history of corneal ulcers or perforation.
• Avoid using this medication if you have a history of ocular hypertension.
• Do not use if you have a corneal abrasion or a foreign body in the eye.
• Not suitable for individuals with untreated bacterial eye infections.

The side effects of Phenylephrine, Sulphacetamide, Prednisolone, and Prednisone Eye Syrup/Suspension may include:

• Elevated eye pressure (glaucoma)
• Burning or stinging sensation in the eyes
• Blurred vision
• Itching or redness of the eyes
• Dry eyes
• Sensitivity to light (photophobia)
• Dizziness or headache

Following are the precautions and warnings for Phenylephrine, Sulphacetamide, Prednisolone, and Prednisone Eye Syrup/Suspension:

• This medication should not be used in individuals with known allergies to any of its components, including Phenylephrine, Sulphacetamide, Prednisolone, or Prednisone.
• Avoid using this eye suspension if you have a fungal, viral, or tubercular eye infection, as it is not effective against these conditions and may mask symptoms.
• Patients with glaucoma or those at risk of glaucoma should use this medication with caution, as it may increase intraocular pressure.
• Do not wear contact lenses while using this eye medication; wait until the treatment is completed.
• Prolonged use of this medication may lead to increased intraocular pressure, cataract formation, or secondary eye infections; regular eye examinations are recommended.
• Children should use this medication under the supervision of a healthcare professional.
• If you have a history of eye surgery or injury, consult your doctor before using this medication.
• If you experience eye pain, changes in vision, or worsening of eye symptoms, discontinue use and seek medical advice immediately.

Following are the drug interactions for Phenylephrine, Sulphacetamide, Prednisolone, and Prednisone Eye Syrup/Suspension:

• Concomitant use with other ophthalmic medications containing imidazoles may cause a reduction in therapeutic effect.
• The use of Prednisolone and Prednisone with non-steroidal anti-inflammatory drugs (NSAIDs) may increase the risk of gastrointestinal bleeding and ulcers.
• Anticoagulants such as warfarin may have their effects enhanced, increasing the risk of bleeding.
• Phenylephrine may interact with monoamine oxidase inhibitors (MAOIs), potentially leading to increased blood pressure.
• Sulfonamides may decrease the efficacy of oral antidiabetic drugs, requiring adjustments in dosage.
• Live virus vaccines may have decreased efficacy when administered concurrently with corticosteroids like Prednisolone.
• Caution is advised when using with other ocular medications, as it may increase the risk of adverse effects.

Following are the food interactions for Phenylephrine, Sulphacetamide, Prednisolone, and Prednisone Eye Syrup/Suspension:

• It is generally recommended to avoid consuming alcohol while using this medication, as alcohol can temporarily dilate blood vessels, potentially reducing the effectiveness of Phenylephrine, which has a vasoconstricting effect.
• Grapefruit and grapefruit juice should be avoided as they can inhibit the CYP3A4 enzyme, which may lead to increased levels of Prednisolone and Prednisone in the body, potentially causing prolonged side effects.
• High-salt foods should be consumed with caution as Prednisolone and Prednisone can cause sodium retention, leading to increased blood pressure and fluid retention.
• Foods rich in vitamin C, such as citrus fruits and leafy greens, may enhance the anti-inflammatory effects of Prednisolone and Prednisone due to their synergistic properties.
• Sulphacetamide may cause nausea and vomiting in some individuals; eating light, easily digestible meals can help manage these side effects.
• Dairy products and calcium-rich foods might interact with Sulphacetamide, reducing its absorption. Thus, it is advisable to separate these foods from medication intake.
• Spicy foods and hot beverages should be avoided if the medication causes any eye irritation or discomfort.
• Maintaining a balanced diet is essential to support overall eye health and to ensure the medication's effectiveness.

Phenylephrine, Sulphacetamide, Prednisolone and Prednisone Eye Syrup/Suspension should be stored in a cool and dry place, preferably at room temperature, ensuring protection from direct sunlight and moisture. Keep the medication in its original container, tightly sealed, to maintain its integrity. Avoid storage in bathrooms or near heat sources like ovens or radiators, as temperature fluctuations can impact the medicine's effectiveness. Dispose of any unused or expired medication responsibly; refrain from flushing it or pouring it down the drain. Consult a pharmacist or healthcare professional for appropriate disposal methods, and ensure the medication is kept away from children to prevent accidental consumption.

Following are the quick tips for Phenylephrine, Sulphacetamide, Prednisolone and Prednisone Eye Syrup/Suspension:

• Wash your hands thoroughly before applying the eye drops/suspension to avoid contamination.
• Gently pull down your lower eyelid and look up. Place the prescribed number of drops or a thin strip of ointment into the pocket.
• Close your eyes gently and tip your head down for a few minutes to prevent the medication from draining out.
• Avoid touching the dropper or tube tip to your eye or any surface to maintain sterility.
• If you are using multiple eye medications, wait at least 5 minutes between applying each one to prevent washout.
• Store the eye drops/suspension at room temperature, away from direct sunlight and moisture.
• Do not wear contact lenses while using this medication unless advised by your doctor.