BLUEMET 4/500MG TAB

The mechanism of action of Metformin 500mg and Glimepiride 4mg in the tablet is a combination of two anti-diabetic agents. Metformin primarily works by reducing glucose production in the liver and improving insulin sensitivity in peripheral tissues. It inhibits gluconeogenesis and decreases the absorption of glucose in the intestines, leading to lower blood sugar levels. On the other hand, Glimepiride belongs to the sulfonylurea class of drugs and stimulates insulin release from pancreatic beta cells by binding to sulfonylurea receptors. This increased insulin secretion helps to lower blood glucose levels by promoting glucose uptake into cells and reducing gluconeogenesis. Together, these two components work synergistically to enhance glycemic control in individuals with type 2 diabetes mellitus.

Oral anti-diabetic medication.

Tablet

The following are the uses of Metformin 500mg, Glimepiride 4mg Tablet:

• Used for managing type 2 diabetes by controlling blood sugar levels.
• Used to improve insulin sensitivity and reduce glucose production in the liver.
• Used to lower blood glucose levels and increase insulin release from the pancreas.
• Used to manage symptoms and prevent long-term complications of diabetes.
• Used for weight management, as it can help reduce appetite and promote weight loss.
• Used to improve cardiovascular health and lower the risk of heart-related issues in diabetic patients.
• Used to regulate blood sugar levels and prevent diabetic complications during pregnancy.
• Used as part of a comprehensive diabetes treatment plan, often combined with diet and exercise.

In the case of an overdose of Metformin 500mg and Glimepiride 4mg tablets, it is important to recognize the potential severity of the situation. Symptoms may include severe nausea, vomiting, abdominal pain, and in extreme cases, lactic acidosis. Immediate medical intervention is necessary, and individuals should seek emergency care promptly. Prompt action can help mitigate the risks associated with an overdose and ensure appropriate treatment is administered. It is crucial to act quickly and not delay seeking professional medical advice.

In the case of a missed dose of Metformin 500mg, take it as soon as you remember, but if it's almost time for your next dose, skip the missed dose and continue with your regular dosing schedule. For Glimepiride 4mg, if you miss a dose, take it as soon as you remember, but do not double the dose to catch up. If it's closer to your next dose, skip the missed dose and resume your regular dosing schedule. It's important to maintain a consistent medication routine, but if you frequently miss doses, inform your healthcare provider for further guidance.

To take the Metformin 500mg and Glimepiride 4mg tablet, swallow one tablet whole with a full glass of water, preferably during a meal or as directed by your healthcare provider, once daily or as instructed by your doctor.

Following are the conditions/situations when Metformin 500mg and Glimepiride 4mg Tablet should not be taken:

• Avoid if you have a known allergy to Metformin, Glimepiride, or any other sulfonylurea medications.
• Not suitable for individuals with diabetic ketoacidosis.
• Should not be used if you have severe kidney or liver disease.
• Contraindicated in patients with a history of heart disease or blood vessel disease.
• Not recommended for individuals with respiratory diseases or lung infections.
• Avoid if you have a history of alcohol abuse or heavy alcohol consumption.
• Should not be taken if you are breastfeeding, as it may pass into breast milk.
• Do not take if you have a scheduled surgery or a recent injury, as it can affect blood sugar control.
• Not suitable for individuals with a history of glucose-6-phosphate dehydrogenase (G6PD) deficiency.

The side effects of Metformin 500mg, Glimepiride 4mg Tablet may include:

• Nausea and vomiting
• Diarrhea or stomach pain
• Metallic taste in the mouth
• Loss of appetite
• Dizziness or lightheadedness
• Skin rash or itching
• Muscle pain or weakness
• Low blood sugar levels

Following are the precautions and warnings for Metformin 500mg, Glimepiride 4mg Tablet:

• Individuals with a known allergy to Metformin or Glimepiride should not take this medication.
• Patients with kidney or liver disease must exercise caution and inform their doctor, as dosage adjustments may be necessary.
• Regular monitoring of kidney function and liver enzymes is recommended while on this medication.
• Patients with a history of heart disease should be cautious and inform their doctor, as Glimepiride can cause hypoglycemia.
• Avoid excessive alcohol consumption while taking this medication, as it may increase the risk of lactic acidosis.
• Elderly patients may be more susceptible to the side effects of Metformin and Glimepiride; close monitoring is advised.
• This medication may cause blurred vision or dizziness; patients should be cautious when driving or operating machinery.
• Pregnant and breastfeeding women should consult their doctor before taking this medication, as it may affect blood sugar control.

Following are the drug interactions for Metformin 500mg and Glimepiride 4mg Tablet:

• Concomitant use with other glucose-lowering medications like insulin or sulfonylureas may result in additive hypoglycemic effects, requiring dose adjustments.
• Metformin can interact with contrast agents used in medical imaging procedures, increasing the risk of lactic acidosis. Temporary discontinuation before procedures is often recommended.
• Drugs that affect kidney function, such as ACE inhibitors or diuretics, may alter Metformin's elimination, necessitating dosage adjustments.
• Glimepiride may potentiate the effects of other antidiabetic drugs, including acarbose and miglitol, leading to increased hypoglycemic risk.
• Alcohol consumption can increase the risk of hypoglycemia when taking Glimepiride, and monitoring is necessary.
• Nonsteroidal anti-inflammatory drugs (NSAIDs) might reduce Glimepiride's glucose-lowering effect, requiring closer blood sugar monitoring.
• Certain medications like corticosteroids, beta-adrenergic agonists, and thyroid hormones can counteract Glimepiride's action, necessitating increased monitoring.

Following are the food interactions for Metformin 500mg and Glimepiride 4mg Tablet:

• Alcohol intake should be limited as it can increase the risk of hypoglycemia, especially with Glimepiride.
• Avoid excessive consumption of grapefruit and grapefruit juice as they can interfere with the metabolism of Glimepiride, potentially leading to increased drug levels and side effects.
• Metformin may cause a decrease in vitamin B12 absorption, so ensure you are getting enough vitamin B12 through diet or supplements.
• Maintain a balanced diet with consistent carbohydrate intake. Avoid excessive sugar and highly refined carbohydrates.
• Avoid fasting or skipping meals, especially when taking Glimepiride, to prevent hypoglycemia.
• Be cautious with high-fat meals as they can affect the absorption and effectiveness of both medications.
• Follow a healthy diet plan as advised by your healthcare provider, focusing on portion control and a variety of whole grains, lean proteins, fruits, and vegetables.
• Stay hydrated, as Metformin can sometimes cause mild gastrointestinal side effects, and adequate fluid intake may help minimize these.

Metformin 500mg, Glimepiride 4mg Tablets should be stored in a cool and dry place, preferably at room temperature, ensuring protection from light and moisture. The original packaging should be tightly sealed to maintain its integrity and prevent contamination. Avoid storing the tablets in bathrooms or areas exposed to heat, as temperature fluctuations can impact their effectiveness. Proper disposal is crucial; do not flush or pour them down the drain. Consult a pharmacist or healthcare professional for guidance on environmentally friendly disposal methods. Keep the medication out of children's reach to prevent accidental consumption, and always adhere to the prescribed dosage and duration.

Following are the quick tips for Metformin 500mg and Glimepiride 4mg Tablet:

• Always take the medication as directed by your doctor; do not alter the dosage.
• Take the tablet with a full glass of water, preferably with a meal.
• Maintain a consistent daily routine for taking the medicine.
• Avoid crushing or chewing the tablet; swallow it whole.
• If you experience nausea, take the tablet with food to minimize discomfort.
• Regularly monitor your blood sugar levels as advised by your healthcare provider.
• Keep the medication in a cool, dry place, away from direct sunlight.