BM MILK THISTLE TAB (42S)

Silybum marianum (commonly known as Milk Thistle) contains silymarin, which is primarily composed of flavonolignans such as silybin, silydianin, and silychristin. These compounds exert their effects by influencing various cellular processes. The primary mechanism of action is associated with silymarin's ability to interact with the cell membrane, particularly the phospholipid bilayer. Silymarin can inhibit the binding of toxins to cell membrane receptors, thus preventing their entry into cells. It also stabilizes cell membranes, reducing their permeability and protecting against damage caused by reactive oxygen species. Furthermore, silymarin promotes protein synthesis, which aids in regenerating damaged hepatocytes (liver cells) and enhances the production of glutathione, a crucial antioxidant that supports liver detoxification processes.

Hepatoprotective, Silymarin-based

Tablet

The following are the uses of silybum marianum Tablet:

• Used for liver protection and detoxification, supporting liver function in various liver conditions.
• Used for reducing liver inflammation and promoting liver cell regeneration.
• Used for managing cholesterol levels and promoting healthy blood lipid profiles.
• Used for treating liver diseases like hepatitis, cirrhosis, and fatty liver disease.
• Used for alleviating liver-related symptoms such as jaundice and abdominal discomfort.
• Used for supporting overall liver health and enhancing its ability to filter toxins.
• Used for preventing liver damage caused by alcohol consumption or environmental toxins.

In the case of an overdose of Silybum marianum tablets, it is important to remain calm and take swift action. Contact your local poison control center or emergency medical services immediately. They will provide guidance based on the specific circumstances and the amount ingested. Do not induce vomiting unless advised by a healthcare professional, as it may not be suitable for all cases. Prompt medical assessment is vital to ensure appropriate treatment and minimize potential complications.

In the case of a missed dose of Silybum marianum tablets, it is important to take the medication as soon as you remember. If it is almost time for your next scheduled dose, skip the missed one and continue with your regular dosing schedule. Do not take a double dose to make up for a missed one, as this may increase the risk of side effects. It is recommended to set a daily reminder or keep the medication in a visible place to help you remember to take it at the correct time each day. Consult your healthcare provider if you have any concerns or if you miss multiple doses.

To take Silybum Marianum tablets, simply swallow one tablet with a glass of water, preferably during or after a meal, following the dosage instructions provided by your healthcare professional or as directed on the product packaging.

Following are the conditions when Silybum marianum Tablet should not be used:

• Not suitable for individuals with a known allergy to any of the ingredients, including milk thistle or related plants.
• Contraindicated in patients with a history of liver transplant or other liver-related surgeries.
• Should not be used by pregnant or breastfeeding women.
• Not recommended for individuals with a history of liver disease or those currently experiencing liver problems.
• Avoid use if you have a known bleeding disorder or are taking blood-thinning medications.
• Do not take if you have a blocked bile duct or bile duct cancer.
• Contraindicated in individuals with a history of hormone-sensitive cancers, such as breast, uterine, or ovarian cancer.
• Should not be used in patients with a history of severe gastrointestinal issues, such as stomach ulcers or gallstones.

The side effects of Silybum marianum Tablet may include:

• Gastrointestinal issues such as nausea, diarrhea, and stomach discomfort.
• Headaches and dizziness.
• Skin reactions like rashes, itching, or hives.
• Allergic reactions, which can range from mild to severe.
• Fatigue and weakness.
• Insomnia or changes in sleep patterns.
• Mild joint or muscle pain.
• Changes in taste or appetite.

Following are the precautions and warnings for Silybum Marianum Tablet:

• Not recommended for individuals with a known allergy to milk thistle or related plants from the Asteraceae/Compositae family.
• Patients with liver disease should use this medication with caution and under medical supervision, as it may affect liver function.
• Not suitable for children, and special care should be taken when administering to the elderly.
• May cause an allergic reaction in individuals sensitive to plants like ragweed, daisies, marigolds, or chrysanthemums.
• Exercise caution if you have a bleeding disorder, as it might slow blood clotting.
• Avoid use if you have a hormone-sensitive condition, as it may have estrogen-like effects.
• If you are scheduled for surgery, inform your doctor about all medications you are taking, including Silybum marianum.

Following are the drug interactions for Silybum Marianum Tablet:

• May reduce the effectiveness of oral contraceptives and hormone replacement therapy.
• Can increase the effects of certain antihyperlipidemic medications, requiring dosage adjustments.
• May interfere with the metabolism of medications processed by the liver's cytochrome P450 system, including some antidepressants, antihistamines, and antiepileptic drugs.
• Co-administration with certain medications like amitriptyline, diazepam, and simvastatin may lead to increased drug levels and potential side effects.
• Can enhance the anticoagulant effects of warfarin, necessitating closer monitoring of INR values.
• May interact with medications that are substrates of P-glycoprotein, affecting their distribution and elimination.
• Use with caution alongside drugs that are sensitive substrates of CYP3A4, as it may alter their plasma concentrations.

Following are the food interactions for Silybum Marianum Tablet:

• Avoid grapefruit and grapefruit juice as they may interfere with the breakdown of the active compounds in the liver, potentially increasing the risk of liver-related side effects.
• Limit or avoid alcohol consumption as it may increase the burden on the liver and reduce the effectiveness of the supplement.
• Caffeine-rich foods and beverages like coffee, tea, and energy drinks may decrease the absorption of silymarin, the active compound in Silybum marianum.
• High-fat meals can delay the absorption of silymarin, leading to reduced bioavailability.
• Consuming foods rich in antioxidants, like berries and dark leafy greens, may enhance the supplement's benefits due to their synergistic effects.
• Spices such as turmeric and black pepper may improve the bioavailability of silymarin, increasing its effectiveness.
• Dairy products may interfere with the absorption of silymarin, so consider separating the supplement and dairy intake by a few hours.
• Certain vegetables like broccoli and cauliflower, known for their glucosinolate content, may support liver health and work in conjunction with Silybum marianum.

Silybum marianum tablets should be stored in a cool and dry place, preferably at room temperature, away from direct exposure to sunlight, heat, and moisture. The original container should be tightly sealed to maintain its integrity and prevent contamination. It is crucial to adhere to the expiration date on the packaging and dispose of any unused or expired tablets promptly. Proper disposal methods should be followed, avoiding flushing or pouring them down the drain. Instead, consult a pharmacist or healthcare professional for guidance on safe disposal practices. Keep the medication out of children's reach to prevent accidental ingestion, ensuring the safety and well-being of your household.

Following are the quick tips for Silybum Marianum Tablet:

• Consult a healthcare professional for dosage instructions based on your health needs.
• Swallow the tablet whole with a glass of water for easy consumption.
• Maintain a consistent schedule for taking the tablets as advised by your doctor.
• Avoid crushing or chewing the tablet for optimal effectiveness.
• Store the tablets in a cool, dry place, away from direct sunlight and moisture.
• Do not share this medication with others, even if they have similar symptoms.
• Inform your doctor if you have any medical conditions or are taking other medications.
• Regularly monitor your progress and report any unusual symptoms to your healthcare provider.