Bonacal D3 (500mg/800IU) 60 Tablets

Cholecalciferol, also known as vitamin D3, has a primary mechanism of action that involves its role in calcium and phosphate homeostasis. When administered, cholecalciferol is metabolized in the liver to form 25-hydroxyvitamin D (calcifediol), which is further converted in the kidneys to its active form, 1,25-dihydroxyvitamin D (calcitriol). Calcitriol acts as a hormone, binding to the vitamin D receptors (VDR) present in various target cells throughout the body. This binding activates the VDR, which then dimerizes with the retinoid X receptor (RXR). The VDR-RXR complex regulates gene expression by binding to specific DNA sequences, known as vitamin D response elements (VDREs), in the promoter regions of target genes. This process leads to the modulation of gene transcription, primarily influencing the absorption of calcium and phosphate in the intestines, reabsorption in the kidneys, and mobilization of calcium from bones. The active form of vitamin D promotes the synthesis of calcium-binding proteins in the intestine, enhancing calcium absorption. It also increases renal tubular reabsorption of calcium and phosphate, while stimulating osteoclast activity to release calcium from bones, thereby maintaining optimal calcium and phosphate levels in the body.

Cholecalciferol 20,000,000iu

Vitamin D analog

Tablet

The following are the uses of Cholecalciferol 20,000,000iu Tablet:

• Used for treating and preventing Vitamin D deficiency, ensuring adequate levels for overall health.
• Used to strengthen bones and prevent conditions like rickets and osteoporosis by aiding in calcium absorption.
• Used for managing conditions causing poor nutrient absorption, ensuring Vitamin D intake.
• Used in maintaining muscle strength and nerve function, crucial for physical well-being.
• Used for supporting immune system health and reducing the risk of respiratory infections.
• Used in the prevention of certain cancers by regulating cell growth and differentiation.
• Used to manage chronic kidney disease, where Vitamin D production is often impaired.
• Used to improve overall well-being and energy levels, especially in individuals with limited sun exposure.

In the case of an overdose of Cholecalciferol 20,000,000 IU tablets, the symptoms can vary depending on the amount ingested. High doses may lead to hypercalcemia, characterized by nausea, vomiting, weakness, and frequent urination. Severe cases can result in kidney damage, bone pain, and even cardiac arrest. Prompt medical intervention is necessary, and treatment may involve intravenous fluids, medications to lower calcium levels, and monitoring of vital organ functions.

In the case of a missed dose of Cholecalciferol 20,000,000 IU Tablet, it is important to take the missed dose as soon as you remember. However, if it is almost time for your next scheduled dose, skip the missed dose and continue with your regular dosing schedule. Do not take a double dose to make up for a missed one. If you miss multiple doses, contact your healthcare provider for guidance on how to safely adjust your dosage and get back on track with your treatment plan.

To take Cholecalciferol 20,000,000 IU tablets, swallow the tablet whole with a glass of water, preferably with a meal or as directed by your healthcare professional, ensuring you follow the prescribed dosage and frequency as instructed by your doctor.

Following are the conditions or circumstances when Cholecalciferol 20,000,000 IU Tablet should not be taken:

• Allergy or hypersensitivity to Cholecalciferol or any of its excipients.
• Patients with hypervitaminosis D (excessive levels of vitamin D in the body).
• Individuals with hypercalcemia (high blood calcium levels) or conditions that may lead to hypercalcemia, such as primary hyperparathyroidism or sarcoidosis.
• Patients with conditions causing hypercalciuria (high calcium levels in urine) and a risk of kidney stones.
• Should not be used in patients with renal (kidney) impairment or kidney failure.
• Not suitable for individuals with evidence of vitamin D toxicity.
• Contraindicated in patients with Williams syndrome.

The side effects of Cholecalciferol 20,000,000 IU Tablet may include:

• Nausea and vomiting
• Constipation or diarrhea
• Loss of appetite
• Dry mouth
• Metallic taste in the mouth
• Fatigue and weakness
• Muscle or joint pain
• Increased calcium levels in the blood (hypercalcemia), which can lead to kidney problems

Following are the precautions and warnings for Cholecalciferol 20,000,000 IU Tablet:

• Avoid taking more than the recommended dosage; an overdose of cholecalciferol can lead to serious health complications.
• Patients with a history of kidney stones, kidney disease, or hypercalcemia should exercise caution and consult a doctor before use.
• Regular monitoring of calcium levels in the blood is essential, especially for those with a history of high calcium levels.
• Not suitable for individuals with a known allergy to vitamin D or any of its components.
• Cholecalciferol may interact with certain medications; inform your doctor about all the medicines you are currently taking.
• Consult a healthcare professional if you are pregnant, planning to become pregnant, or breastfeeding to ensure safe usage.
• Do not use this medication to treat conditions caused by inadequate calcium intake or other deficiencies without medical advice.
• Keep out of reach of children and store in a cool, dry place.

Following are the drug interactions for Cholecalciferol 20,000,000 IU Tablet:

• Anticonvulsants like phenobarbital and phenytoin can reduce the effectiveness of cholecalciferol by increasing its metabolism.
• Cholestyramine and colestipol may decrease the absorption of cholecalciferol by binding to it in the gastrointestinal tract.
• Orlistat can reduce the absorption of fat-soluble vitamins like cholecalciferol, leading to reduced vitamin D levels.
• Thiazide diuretics can increase calcium reabsorption in the kidneys, which may enhance the effects of cholecalciferol on calcium metabolism.
• Calcium channel blockers such as verapamil and diltiazem may increase the risk of hypercalcemia when used with cholecalciferol.
• Corticosteroids can decrease calcium absorption and bone formation, potentially counteracting the effects of cholecalciferol.
• Aluminum-containing antacids can reduce the absorption of cholecalciferol, especially with long-term use.

Following are the food interactions for Cholecalciferol 20,000,000 IU Tablet:

• Avoid excessive consumption of foods rich in Vitamin D, such as fatty fish (salmon, mackerel), egg yolks, and fortified dairy products, as it may lead to Vitamin D toxicity.
• Limit your intake of calcium-rich foods like milk, yogurt, and cheese, as Vitamin D increases calcium absorption, potentially causing an imbalance.
• Grapefruit and grapefruit juice should be consumed with caution as they can interfere with the metabolism of Vitamin D, leading to higher blood levels.
• Avoid alcohol, as it may hinder the absorption of Vitamin D and negatively impact bone health.
• High-fiber foods like whole grains, legumes, and leafy greens can enhance Vitamin D absorption, ensuring proper utilization.
• Consuming Vitamin D supplements with a meal containing healthy fats can improve absorption, as Vitamin D is fat-soluble.
• Certain medications, such as steroids and anti-seizure drugs, may affect Vitamin D metabolism, so consult your doctor regarding any potential interactions.
• Always follow the dosage instructions provided by your healthcare professional to ensure safe and effective use.

Cholecalciferol 20,000,000iu Tablets should be stored in a secure and dry location, preferably in a medicine cabinet or a designated storage area, ensuring they are out of reach of children and pets. Maintain a consistent room temperature, avoiding excessive heat or cold, as well as direct exposure to sunlight or moisture, which can degrade the medication. Keep the tablets in their original container, tightly sealed, to prevent contamination and maintain their integrity. Regularly check the expiration date, and if the medication is no longer needed or has expired, proper disposal is crucial. Do not discard the tablets in regular trash or flush them down the toilet; instead, follow local guidelines for pharmaceutical waste disposal or consult a pharmacist for guidance on safe and environmentally friendly disposal methods.

Following are the quick tips for Cholecalciferol 20,000,000iu Tablet:

• Ensure you are prescribed this medication by a healthcare professional.
• Take the tablet as directed by your doctor, typically once every week or month.
• Consume the tablet with a full glass of water for better absorption.
• Maintain a consistent schedule for taking the medication.
• Avoid consuming dairy products, tea, or coffee immediately after taking the tablet.
• Store the medication in a cool, dry place, away from children.
• Do not crush or chew the tablet; swallow it whole.