Bone-Lift (0.5mcg) 30 Tablets

Alfacalcidol is a biologically active synthetic vitamin D3 analog that undergoes metabolism in the liver to form 1,25-dihydroxyvitamin D3, the active form of vitamin D3 in the body. It possesses pharmacological actions similar to calcitriol, which is produced naturally in the kidneys, but is considered less potent, approximately 1000 times. Alfacalcidol binds to the vitamin D receptor, enabling it to mediate its effects through the transcriptional regulation of specific genes involved in calcium and phosphorus metabolism and bone health. Alfacalcidol is used primarily in the management and treatment of disorders related to calcium and phosphorus metabolism, including hypoparathyroidism, renal osteodystrophy, calcium homeostasis, bone disorders, and autoimmune diseases. In the management of hypoparathyroidism, Alfacalcidol's actions to stimulate calcium absorption and bone resorption help maintain serum calcium concentrations. For renal osteodystrophy in chronic kidney disease, Alfacalcidol can help promote calcium absorption and stimulate osteoblast activity while suppressing osteoclast activity. Alfacalcidol increases calcium uptake in the intestines and reabsorption in the kidneys, maintaining normal blood calcium levels. In bone disorders, it modifies bone metabolism and helps prevent steroid-induced osteoporosis by promoting osteoblast function and reducing osteoclast-mediated bone resorption. Furthermore, Alfacalcidol has immunomodulatory effects, making it useful in the treatment of various autoimmune diseases. Overall, Alfacalcidol's ability to manipulate calcium metabolism and bone homeostasis makes it a valuable tool in the treatment of several medical conditions.

Alfacalcidol

D3 Vitamins

Tablets

Unveiling its multifaceted uses and transformative applications as follows:

• Osteoporosis treatment and prevention of bone loss in adults and adolescents on contraceptives or glucocorticoids.
• Treatment of hypocalcemia in people with kidney disease or failure.
• Alfacalcidol serves as an antagonist of vitamin D activity, mitigating these effects to help restore healthy levels of calcium in the body.

Tailoring Treatment for Optimal Health, Prescribed Medication Dosage is:

• For mild to moderate renal osteodystrophy- 0.25-1.0 micrograms/day administered orally ALSOR
• For the treatment of hypophosphatemia and metabolic bone disease in adult cancer patients receiving intravenous glucose infusion- 1.0 micrograms/day administered orally
• For the prevention of renal osteodystrophy in adults with renal impairment- 0.5-1.0 micrograms/day administered orally
• For the treatment of vitamin D dependent rickets kindling- 5-10 micrograms/kg/day of body weight administered orally
• For the treatment of hypophosphatemia in chronic renal failure- 1.0 micrograms/day administered orally

Alfacalcidol overdose requires urgent medical attention and may lead to severe complications such as kidney damage and abnormalities in calcium and phosphate levels. Healthcare providers may initiate intravenous calcium glucose infusions to correct these imbalances and prevent further complications. They will also monitor the patient's mineral levels, kidney function, and parathyroid hormone levels to gauge the severity of the overdose and the effectiveness of treatments. Fluid replacement may be administered to prevent or address dehydration, a potential side effect of the overdose. Kidney function monitoring is also crucial to identify any signs of injury and determine whether additional medications are necessary to support kidney health. A balanced and controlled diet from nutritional experts is another aspect of supportive care. This diet will avoid exacerbating imbalances in calcium and phosphate levels. Depending on individual symptoms and the severity of the condition, withdrawal of alfacalcidol medication may be advised to prevent further absorption into the body. Overall, it is important to seek medical attention in case of an alfacalcidol overdose, as the prompt intervention and personalized treatment by a medical professional are crucial to addressing the potential risks associated with the overdose.

If you happen to miss a dose of Alfacalcidol, it is recommended that you take it as soon as possible. However, if it is almost time for your next dose, it is advised that you skip the missed dose and continue with your regular dosage schedule. It is imperative that you do not double the dose as this may lead to an overdose or adverse side effects. To ensure the safest and most effective treatment, it is important to maintain a regular dosing schedule and follow the advice of your medical professional. If you have any questions or concerns about your missed dose or adjusting your dosage, contact your doctor or a medical professional for guidance. They may provide specific instructions based on your health condition and the prescribed treatment plan, which will ensure you're addressing the issue properly and promptly.

Alfacalcidol is a medication that treats osteoporosis, a condition that weakens the bones. Your doctor will determine the specific dosing regimen depending on your condition's severity. It should be taken orally, either as a tablet or a solution, followed by swallowing with water or drinking immediately if dispersed in water. Ensure consistent consumption timing each day, usually once daily in the morning, with or without food, along with adequate calcium intake. Complete the full course of treatment, as premature stoppage may cause a relapse. Your doctor may also recommend regular monitoring tests to ensure effectiveness and minimize side effects. Follow• up appointments with your doctor are essential to adjust the dosage as needed and to assess your overall health.

Discerning instances where this medication may not be appropriate:

• You have recently undergone parathyroid surgery • Alfacalcidol 0.5μg is not recommended for people who have had surgery to remove the parathyroid gland or glands.
• You have high levels of calcium in your blood • Already high blood calcium levels mean you could experience further increases through use of Alfacalcidol 0.5μg.
• You have a sensitivity to Alfacalcidol or similar medications • If you have had allergic reactions or side effects from Alfacalcidol 0.5μg or other medications in the same class, you should not take this medication.
• You have a kidney injury or impaired kidney function • Alfacalcidol 0.5μg is excreted by the kidneys, so if your kidney function is impaired, there is a risk of excess calcium in the blood.
• You are taking other medications that interact with Alfacalcidol • Interaction with other medications can affect effectiveness or increase the risk of side effects.

Unraveling the side effects lurking behind this medications are as follows:

• Thinning of bones (osteoporosis)
• Headaches
• Bone or joint pain
• Nausea, vomiting, and diarrhea
• Muscle weakness
• Confusion or trouble concentrating

Alfacalcidol, a vitamin D derivative, is unique in that it circulates in the bloodstream as a lipid-soluble molecule, unlike other vitamin D metabolites which are stored in the liver. After absorption from the intestine, Alfacalcidol is chemically modified to allow its storage in the body, where it has a half-life of approximately 15 hours. This length of time is longer than other vitamin D metabolites, indicating that it can be stored for shorter periods of time. The action of Alfacalcidol involves binding to the vitamin D receptor (VDR), a nuclear receptor protein, initiating a series of changes that regulate gene expression and result in specific metabolic processes. This ultimately leads to the synthesis of calcium binding proteins that promote calcium absorption and metabolism, supporting healthy calcium homeostasis. Alfacalcidol is known to be effective in treating endocrinology and nephrology disorders such as vitamin D deficiency, hypoparathyroidism, and certain types of rickets. It is also given to patients who have had kidney transplants to prevent vitamin D deficiency and associated diseases. Therefore, despite its different storage and metabolism compared to other vitamin D metabolites, Alfacalcidol's lipid metabolism within the body is essential for its therapeutic effects and metabolic purposes.

Alfacalcidol is a medication administered to treat and prevent low blood calcium levels. To ensure its effectiveness and to monitor any potential side effects, several laboratory tests are conducted. These tests include the following: