Bonelift (1mcg) 30 Tablets

Alfacalcidol, a synthetic vitamin D analog, exerts its therapeutic effects by mimicking the actions of vitamin D in the body. Upon administration, alfacalcidol is rapidly converted in the liver to 1,25-dihydroxyvitamin D, which is the active form of vitamin D. This active metabolite binds to vitamin D receptors (VDR) present in various target tissues, primarily the intestine, kidneys, and bones. By activating VDR, alfacalcidol enhances intestinal absorption of calcium and phosphorus, promotes renal tubular reabsorption of calcium, and mobilizes calcium and phosphate from bone. These actions collectively contribute to increased calcium and phosphate levels in the blood, promoting bone mineralization and strengthening skeletal integrity. The mechanism of action involves the regulation of gene expression related to calcium and phosphate homeostasis, thereby playing a crucial role in the treatment of conditions associated with vitamin D deficiency or impaired calcium metabolism.

Alfacalcidol 1mcg

Vitamin D Analogue

Capsule

The following are the uses of Alfacalcidol 1mcg Tablet:

• Used for treating and managing calcium deficiency in conditions like hypoparathyroidism, pseudohypoparathyroidism, and renal osteodystrophy.
• Used to maintain calcium levels in patients with chronic kidney disease.
• Used for preventing and treating bone disorders, promoting bone formation, and reducing bone loss.
• Used to manage calcium and phosphate imbalances in patients on dialysis.
• Used to alleviate bone pain and improve bone health in certain bone diseases.
• Used to support calcium absorption and correct low blood calcium levels.
• Used to enhance vitamin D levels and improve overall bone metabolism.

Tailoring Treatment for Optimal Health, Prescribed Medication Dosage is:

• For adults taking immunosuppressants for mild to moderate hypophosphatemia- Start with 1 tablet of Alfacalcidol 0.5μg per day.
• For treating vitamin D dependent rickets and kidney hemodialysis- Start with 1-2 tablets of Alfacalcidol 0.5μg per day.
• For children- Doses are based on weight and medical condition, so follow the doctor's instructions.

In the case of an overdose of Alfacalcidol 1mcg Tablets, it is important to act swiftly. The initial symptoms may include nausea, vomiting, and increased thirst. More severe effects can lead to muscle weakness, confusion, and irregular heart rhythms. If an overdose is suspected, seek medical assistance promptly. Treatment options may involve supportive care, monitoring vital signs, and managing symptoms until the drug's effects wear off.

In the case of a missed dose of Alfacalcidol 1mcg Tablet, it is important to take the medication as soon as you remember. If it is almost time for your next scheduled dose, skip the missed one. Do not double the dose to make up for a missed one. It is crucial to maintain a consistent dosing schedule, so if you frequently forget to take your medication, consider setting reminders or asking a family member to help you stay on track. Consult your healthcare provider if you have any concerns or if you miss multiple doses.

To take Alfacalcidol 1mcg Tablet, place the tablet under your tongue and allow it to dissolve completely, preferably at the same time each day, following the dosage instructions provided by your healthcare professional.

Following are the conditions when Alfacalcidol 1mcg Tablet should not be used:

• Do not take if you have a known allergy or hypersensitivity to Alfacalcidol or any of the excipients in the formulation.
• Contraindicated in patients with hypercalcemia (high levels of calcium in the blood).
• Avoid using if you have evidence of vitamin D toxicity.
• Not recommended for individuals with impaired kidney function or kidney failure.
• Do not take if you have uncontrolled or severe hyperphosphatemia (high levels of phosphate in the blood).
• Alfacalcidol is not suitable for patients with hypercalciuria (high levels of calcium in urine) and a history of kidney stones.
• Avoid using if you have a condition called hypervitaminosis D (vitamin D excess).
• Should not be used in individuals with a history of calcification in soft tissues or blood vessels.

The side effects of Alfacalcidol 1mcg Tablet may include:

• Nausea and vomiting.
• Constipation or diarrhea.
• Loss of appetite.
• A headache or dizziness.
• Weakness or fatigue.
• Increased thirst and urination.
• Muscle or joint pain.
• Elevated calcium levels in the blood (hypercalcemia), which may lead to symptoms like confusion, extreme thirst, and frequent urination.

Following are the precautions and warnings for Alfacalcidol 1mcg Tablet:

• This medication should be used with caution in patients with kidney disease, as it may require dosage adjustments.
• Regular monitoring of calcium and phosphate levels in the blood is necessary during treatment.
• Patients with a history of sensitivity or allergy to any vitamin D compound should avoid this medication.
• Alfacalcidol can cause an increase in calcium levels, so caution is advised in patients with conditions like hypercalcemia or hypercalciuria.
• It may cause hypervitaminosis D (excess vitamin D) if used for prolonged periods or at high doses.
• Not recommended for individuals with hyperparathyroidism, as it can lead to excessive calcium levels.
• Patients should be advised to maintain adequate hydration and avoid dehydration during treatment.
• Those with a history of kidney stones should be monitored closely, as this medication may increase the risk of stone formation.

Following are the drug interactions for Alfacalcidol 1mcg Tablet:

• Thiazide diuretics, such as hydrochlorothiazide, may decrease the excretion of calcium, leading to increased calcium levels in the body.
• Corticosteroids like prednisone can enhance the effects of Alfacalcidol, requiring careful monitoring of calcium levels.
• Anticonvulsants like phenytoin can reduce the effectiveness of Alfacalcidol by increasing its metabolism.
• Calcium supplements or other vitamin D supplements may result in hypercalcemia when used concurrently with Alfacalcidol.
• Antacids containing magnesium can decrease the absorption of Alfacalcidol, potentially reducing its effectiveness.
• Digitalis medications may be affected by calcium metabolism changes, increasing the risk of digitalis toxicity.
• Some phosphate binders may interfere with Alfacalcidol absorption, requiring close monitoring.

Following are the food interactions to consider with Alfacalcidol 1mcg Tablet:

• Alfacalcidol may interact with high-calcium or vitamin D-fortified foods, as excessive intake of calcium and vitamin D can lead to hypercalcemia. Avoid excessive consumption of dairy products, calcium-fortified juices, and supplements containing calcium or vitamin D.
• Grapefruit and grapefruit juice should be consumed with caution, as they can affect the metabolism of Alfacalcidol, potentially leading to increased drug levels in the body.
• Avoid alcohol consumption as it may increase the risk of kidney damage and interfere with the absorption of Alfacalcidol.
• Limit your intake of foods high in oxalates, such as spinach, rhubarb, and beets, as Alfacalcidol can increase the absorption of oxalates, potentially leading to kidney stone formation.
• Avoid excessive consumption of high-phosphorus foods like meat, dairy, and carbonated beverages, as Alfacalcidol can affect phosphorus metabolism.
• Certain mineral oils and cholesterol-lowering agents may reduce the absorption of Alfacalcidol. Avoid consuming these concurrently with the medication.
• Alfacalcidol may increase the absorption of aluminum from foods or medications containing aluminum, which can be harmful. Avoid antacids or medications containing aluminum while taking Alfacalcidol.
• Some herbal supplements, such as St. John's Wort, may affect the metabolism of Alfacalcidol. Consult a healthcare professional before taking any herbal supplements.

Alfacalcidol 1mcg Tablets should be stored in a cool and dry place, preferably at room temperature, ensuring protection from light and moisture. It is crucial to keep the tablets in their original packaging, tightly sealed, to maintain their integrity. Avoid storing them in bathrooms or near heat-emitting appliances as temperature fluctuations can impact the medication's effectiveness. Proper disposal is essential; do not flush or pour them down the drain. Consult a pharmacist or healthcare professional for guidance on appropriate disposal methods, ensuring environmental safety. Keep the medication away from children to prevent accidental consumption.

Following are the quick tips for Alfacalcidol 1mcg Tablet:

• Take the tablet as directed by your doctor, typically once daily or as instructed.
• Consume the tablet with a full glass of water to aid in swallowing.
• Maintain consistency by taking the tablet at the same time each day.
• Avoid crushing or chewing the tablet; swallow it whole for optimal absorption.
• Inform your doctor if you have any kidney or liver-related issues before taking this medication.
• Store the tablets in a cool, dry place, away from direct sunlight and moisture.
• Do not share your medication with others, even if they have similar symptoms.

Alfacalcidol is a vitamin D derivative that acts as a therapeutic agent for conditions like hypocalcemia and metabolic bone disease among individuals who have kidney failure. The laboratory tests required to accompany Alfacalcidol depend on the individual's medical situation and the condition that is being treated. In general, it is important to monitor vitamin D levels, calcium, and phosphate levels in the blood to ensure they are within the normal range. Given the nature of the medication and its potential impact on the kidneys, kidney function tests are often required, checking for example for BUN (blood urea nitrogen) and creatinine. It is also important to monitor for any potential adverse effects of the medication on kidney function. Other relevant tests may include parathyroid hormone levels and osteocalcin, as well as regular assessments of calcium homeostasis to ensure that the treatment is effective and to avoid the development of hypercalcemia which can lead to serious complications. It is vital to adhere to any testing schedules outlined by your healthcare provider when taking Alfacalcidol to ensure effective use and to monitor for any potential side effects or unintended consequences. The specific testing regime and timing of the tests would be advised by the prescribing physician who can tailor the monitoring to the individual based on their clinical condition and response to the medication.