Bonheal (750/100mg) 30 Capsules

Ibandronic acid, the active ingredient in the 100mg capsule, is a potent bisphosphonate that primarily acts by inhibiting osteoclast-mediated bone resorption. It selectively binds to hydroxyapatite in bone, targeting active bone remodeling sites. Once internalized by osteoclasts, ibandronic acid disrupts their function and induces apoptosis, leading to a reduction in bone resorption. This mechanism helps to slow down bone breakdown, allowing for a more balanced bone remodeling process and potentially increasing bone mineral density. The preferential uptake of ibandronic acid by bone tissue contributes to its therapeutic effect in managing conditions related to excessive bone loss.

Ibandronic acid 100mg

Bisphosphonate.

Capsule

The following are the uses of Ibandronic acid 100mg Capsule:

• Used for treating Paget's disease of bone, a condition where bones become weak and brittle.
• Used to manage bone metastases (cancer that has spread to the bones) to reduce bone pain and fractures.
• Used for treating osteoporosis in postmenopausal women, helping to increase bone density and reduce fracture risk.
• Effective in treating hypercalcemia (high blood calcium levels) caused by certain cancers.
• Used to prevent and treat osteoporosis in men receiving certain hormone treatments.
• Can be used to improve bone health and reduce fracture risk in individuals with certain genetic disorders affecting the bones.
• Used for managing bone health in individuals with kidney disease or after kidney transplant.

In the case of an overdose of Ibandronic acid 100mg Capsules, individuals may experience severe gastrointestinal symptoms such as nausea, vomiting, and abdominal pain. Additionally, there can be a significant impact on the renal system, leading to decreased kidney function and potential acute kidney injury. It is crucial to seek medical assistance promptly, as timely intervention can help manage these symptoms and prevent further complications. Patients should be closely monitored, and appropriate supportive care should be provided to address the specific effects of the overdose.

In the case of a missed dose of Ibandronic acid 100mg Capsule, it is important to take the medication as soon as you remember. However, if it is almost time for your next dose, skip the missed dose and continue with your regular dosing schedule. Do not double the dose to make up for a missed one. If you miss multiple doses, contact your healthcare provider for guidance on how to resume your medication safely, as they may advise you to restart at a lower dose to minimize side effects.

To take Ibandronic acid 100mg Capsule, swallow the capsule whole with a full glass of plain water first thing in the morning, at least 60 minutes before eating or drinking anything else, including other medications, and remain upright (sitting or standing) for at least 60 minutes after taking the medication.

Here are the conditions or situations when Ibandronic acid 100mg Capsule should not be taken:

• Avoid using if you are allergic to Ibandronic acid or any other bisphosphonate medication.
• Not suitable for individuals with low calcium levels in the blood (hypocalcemia).
• Should not be used in patients with severe kidney disease or impaired kidney function.
• Contraindicated in individuals with disorders of the esophagus, such as difficulty swallowing or esophageal stricture.
• Not recommended for patients with severe bone, joint, or muscle pain.
• Avoid using if you have a dental problem or are planning to undergo a dental procedure.
• Do not take this medication if you have a history of ulcers in the stomach or intestines.
• Should not be used in individuals with certain bone conditions, such as osteomalacia or Paget's disease.

The side effects of Ibandronic acid 100mg Capsule may include:

• Bone, joint, or muscle pain
• Nausea and vomiting
• Diarrhea
• Constipation
• Stomach pain or indigestion
• Flu-like symptoms (fever, chills)
• Fatigue and weakness
• Headache

Following are the precautions and warnings for Ibandronic acid 100mg Capsule:

• This medication is intended for oral use only and should not be injected or used intravenously.
• Patients with a history of esophageal disorders, such as difficulty swallowing or existing esophageal disease, should use with caution as it may worsen these conditions.
• It is important to remain upright (standing or sitting) for at least 60 minutes after taking the medication to minimize the risk of esophageal irritation.
• Patients should not lie down for at least 60 minutes after taking the capsule to prevent the risk of esophageal side effects.
• Dental examinations and appropriate preventive dentistry are recommended prior to starting treatment, and regular dental care is important during treatment.
• Ibandronic acid may cause serious kidney problems, including kidney failure. Monitor kidney function and discontinue use if renal impairment occurs.
• Patients with low blood calcium levels (hypocalcemia) should have their calcium levels corrected before starting this medication.
• Individuals with poor dental hygiene or undergoing dental procedures may be at a higher risk of jaw bone problems (osteonecrosis) and should maintain good oral hygiene during treatment.

Following are the drug interactions for Ibandronic acid 100mg Capsule:

• Concomitant use with other bisphosphonates or nephrotoxic drugs may increase the risk of renal toxicity.
• Ibandronic acid can reduce the absorption of calcium, iron, magnesium, and zinc supplements. Separate their administration by at least 2 hours.
• Antacids containing aluminum, magnesium, or calcium can decrease the absorption of Ibandronic acid, so take the antacid at least 30 minutes after the Ibandronic acid dose.
• Corticosteroids may increase the risk of gastrointestinal side effects when used with Ibandronic acid.
• Thiazide diuretics may increase the risk of hypocalcemia, so monitor calcium levels and consider calcium supplementation.
• NSAIDs can increase the risk of gastrointestinal toxicity and should be used with caution.
• The use of loop diuretics with Ibandronic acid may increase the risk of renal impairment, particularly in patients with pre-existing renal issues.
• Proton pump inhibitors (PPIs) may reduce the absorption of Ibandronic acid, so separate their administration by at least 2 hours.

Following are the food interactions for Ibandronic acid 100mg Capsule:

• Avoid consuming food for at least 60 minutes after taking the medication, as it can reduce the absorption of Ibandronic acid.
• Maintain an upright posture (sitting or standing) for at least 60 minutes after taking the medication to minimize the risk of esophageal irritation and ensure proper absorption.
• Avoid consuming dairy products, calcium supplements, or antacids containing calcium, magnesium, or aluminum within 60 minutes of taking Ibandronic acid, as they can bind to the medication and reduce its effectiveness.
• Grapefruit juice should be avoided as it may decrease the absorption of Ibandronic acid, potentially reducing its effectiveness.
• Alcohol intake should be minimized as it can increase the risk of gastrointestinal side effects like stomach upset, heartburn, and irritation of the esophagus.
• Ensure an adequate fluid intake, preferably with plain water, to promote hydration and minimize the risk of gastrointestinal side effects.
• Avoid highly acidic beverages like orange juice or carbonated drinks, as they can irritate the esophagus and potentially reduce the effectiveness of the medication.

Ibandronic acid 100mg capsules should be stored in a cool and dry place, ideally at room temperature, ensuring protection from light and moisture. Keep the medication in its original packaging, tightly sealed to maintain its integrity. It is crucial not to expose the capsules to extreme temperatures, so avoid storage in bathrooms or near heat-emitting appliances. Regularly check the expiration date, and if the medication is no longer needed or has expired, do not flush it or pour it down the drain. Contact your pharmacist or healthcare provider for instructions on safe disposal to prevent environmental contamination. Always keep medicines out of children's reach to prevent accidental ingestion.

Following are the quick tips for Ibandronic acid 100mg Capsule:

• Take the capsule with a full glass of plain water first thing in the morning, at least 30 minutes before eating or drinking anything else.
• Remain upright (sitting, standing, or walking) for at least an hour after taking the medication to prevent heartburn or irritation in the esophagus.
• Avoid taking antacids or other medications within 1 hour before or after taking the capsule to ensure proper absorption.
• Maintain good oral hygiene and regular dental check-ups while using this medication to minimize the risk of jaw-related side effects.
• Inform your doctor if you have any kidney problems as the dosage may need adjustment.
• Do not crush, chew, or suck on the capsule; swallow it whole to ensure effective delivery of the medication.
• Store the capsules at room temperature, away from moisture and light, to maintain their potency.