Bonviva (3mg/3ml) 1 Pre-Filled Syringe

Ibandronic acid, the active ingredient in the 3mg syringe formulation, primarily acts by inhibiting osteoclast-mediated bone resorption. It is a potent bisphosphonate that selectively binds to hydroxyapatite in bone, targeting sites of active bone remodeling. Once bound, ibandronic acid impairs osteoclast function and reduces their ability to resorb bone. This occurs through the inhibition of key enzymes involved in osteoclast-mediated bone degradation, such as farnesyl pyrophosphate synthase, which is essential for osteoclast formation and function. By suppressing osteoclast activity, ibandronic acid effectively reduces bone turnover and promotes the preservation of bone mass, thereby exerting its therapeutic effect in conditions characterized by excessive bone resorption.

Bisphosphonate

Syringe

The following are the uses of Ibandronic Acid 3mg Syringe:

• Used for treating Paget's disease of bone, a condition where bones become weak and brittle.
• Used for preventing bone fractures and complications in patients with bone metastases due to cancer.
• Used for managing hypercalcemia (high blood calcium levels) caused by certain cancers.
• Used for improving bone density and reducing fracture risk in osteoporosis patients.
• Used for inhibiting bone resorption, helping to preserve bone strength.
• Used for treating bone pain associated with bone metastases.
• Used for long-term management of bone health in patients with chronic bone conditions.

In the case of an overdose of Ibandronic Acid 3mg Syringe, it is important to act swiftly. Initial symptoms may include gastrointestinal issues, such as nausea, vomiting, and diarrhea. More severe cases can lead to renal impairment and hypocalcemia. Seek medical assistance promptly, as treatment may involve supportive measures and monitoring of vital signs and renal function. Timely intervention is crucial to managing the potential adverse effects of an overdose.

In the case of a missed dose of Ibandronic Acid 3mg Syringe, it is important to take the missed dose as soon as you remember. However, if it is almost time for your next scheduled dose, skip the missed dose and continue with your regular dosing schedule. Do not take a double dose to make up for a missed one. If you miss multiple doses, contact your healthcare provider for guidance on how to safely resume your medication regimen. It is crucial to maintain consistency in taking your medication as prescribed to ensure its effectiveness.

To administer Ibandronic Acid 3mg Syringe, draw the medication into the syringe, inject it slowly into the vein over a period of 1 to 2 minutes, and ensure the solution is completely infused before discarding the syringe, following the instructions provided by your healthcare professional.

Following are the conditions/situations when Ibandronic Acid 3mg Syringe should not be used:

• Should not be administered to patients with a known hypersensitivity or allergy to Ibandronic Acid or any of the excipients in the formulation.
• Contraindicated in patients with severe kidney disease or impaired renal function.
• Not recommended for individuals with low blood calcium levels (hypocalcemia) or vitamin D deficiency.
• Should not be used in patients with disorders of the esophagus, such as esophageal stricture or achalasia, as it may cause complications.
• Contraindicated during pregnancy and breastfeeding.
• Not suitable for children and adolescents under 18 years of age.
• Should not be used in patients with severe bone, joint, or muscle pain, or those who have experienced osteonecrosis of the jaw.
• Contraindicated in patients with severe gastrointestinal disorders or those who are unable to stand or sit upright for at least 30 minutes after taking the medication.

The side effects of Ibandronic Acid 3mg Syringe may include:

• Flu-like symptoms (fever, chills, muscle pain)
• Bone, joint, or muscle pain
• Nausea and vomiting
• Diarrhea
• Headache
• Dizziness
• Fatigue and weakness
• Stomach pain

Following are the precautions and warnings for Ibandronic Acid 3mg Syringe:

• Patients with known hypersensitivity or allergy to Ibandronic Acid or any of its components should not use this medication.
• Kidney function should be closely monitored during treatment, and dosage adjustments may be necessary for individuals with kidney impairment.
• Dental examinations and necessary dental work should be completed prior to starting treatment to minimize the risk of osteonecrosis of the jaw.
• Patients should maintain good oral hygiene, including regular dental check-ups, while on this medication.
• This medication may cause gastrointestinal side effects; patients should be advised to take the medicine on an empty stomach and remain upright for at least an hour after administration.
• Ibandronic Acid may cause bone, joint, or muscle pain; patients should be advised to report any such symptoms promptly.
• Caution is advised when using this medication in elderly patients, as they may be more susceptible to adverse effects.
• Women who are pregnant or breastfeeding should consult their healthcare provider before using Ibandronic Acid.

Following are the drug interactions for Ibandronic Acid 3mg Syringe:

• Renal toxicity risk increases when combined with other nephrotoxic drugs like aminoglycosides or diuretics.
• Concomitant use with NSAIDs may increase the risk of upper gastrointestinal tract complications.
• Ibandronic acid may decrease the absorption of calcium and some other minerals; separate intake by at least 30 minutes.
• Bisphosphonates, including ibandronic acid, may be associated with osteonecrosis of the jaw, especially when used with chemotherapy, corticosteroids, or other bisphosphonates.
• Antacids containing aluminum, magnesium, or calcium can interfere with the absorption of ibandronic acid and should be avoided.
• Thrombocytopenia and coagulation abnormalities have been reported with bisphosphonate use, especially with high doses; monitor when used with anticoagulants.
• Some studies suggest a potential interaction with loop diuretics, which may increase the risk of renal toxicity.

Following are the food interactions for Ibandronic Acid 3mg Syringe:

• Avoid consuming foods or beverages with high calcium content, such as dairy products (milk, cheese, yogurt), calcium-fortified foods, and calcium supplements, at least 60 minutes before and after taking Ibandronic Acid, as calcium can interfere with its absorption.
• Do not consume foods or drinks with high levels of phosphate, such as cola beverages, as they can decrease the effectiveness of the medication.
• Grapefruit and grapefruit juice should be avoided, as they can alter the blood levels of Ibandronic Acid, potentially leading to decreased absorption.
• Alcohol intake should be limited as it may increase the risk of gastrointestinal side effects like stomach upset and irritation.
• Ensure adequate fluid intake, preferably with plain water, to reduce the risk of esophageal irritation and promote proper absorption.
• Avoid consuming large amounts of food immediately after taking the medication to ensure optimal absorption.
• Maintain a balanced diet rich in nutrients like vitamin D and protein, as these are essential for maintaining bone health.

Ibandronic Acid 3mg Syringe should be stored in a secure and controlled environment, preferably in a designated storage area with restricted access. It should be kept in a cool, dry place, away from direct sunlight, heat, and moisture to maintain its stability. The syringe should be stored in its original packaging to protect it from contamination and to ensure proper labeling. Do not freeze the medication as it may affect its potency. When disposing of the syringe, follow local regulations and guidelines for the safe disposal of medical waste. Avoid throwing it into the trash or recycling bins; instead, utilize designated medical waste collection programs or consult healthcare professionals for appropriate disposal methods. This practice ensures the safety of both individuals and the environment.

Following are the quick tips for Ibandronic Acid 3mg Syringe:

• Administer the injection as instructed by your doctor, usually once a month.
• Ensure you receive proper training on how to self-inject this medication.
• Allow the syringe to reach room temperature before injecting.
• Clean the injection site with an alcohol wipe and inject the medication under the skin.
• Do not inject into muscles or veins; follow the prescribed injection technique.
• Dispose of used syringes safely in a puncture-proof container.
• Stay upright for at least 60 minutes after the injection to prevent side effects.