BREMAX 60ML SYP

Tolbuterol HCl, the active ingredient in the syrup/suspension form, acts as a selective beta-2 adrenergic receptor agonist. When administered, it binds to beta-2 receptors in the smooth muscle cells of the airways, leading to bronchodilation. This mechanism relaxes the smooth muscles surrounding the bronchial tubes, resulting in the widening of the airways and facilitating easier breathing. Tolbuterol's selective action on beta-2 receptors helps to minimize potential cardiovascular side effects associated with non-selective beta-agonist drugs. By promoting relaxation of the airway smooth muscles, Tolbuterol HCl effectively alleviates bronchospasm and provides relief from respiratory symptoms.

Bronchodilator

Suspension

The following are the uses of Tolbuterol HCl Syrup/Suspension:

• Used for treating asthma and relieving symptoms such as wheezing, coughing, and shortness of breath.
• Used for managing chronic obstructive pulmonary disease (COPD) to improve breathing and reduce exacerbations.
• Used for preventing exercise-induced bronchospasm, allowing for better exercise tolerance.
• Used for relieving bronchospasm in conditions like emphysema, providing better airflow.
• Used for managing allergies and asthma triggered by allergens, helping to control symptoms.
• Used for its bronchodilator properties to relax airway muscles and improve lung function.
• Used for long-term asthma control, often in combination with other medications.

In the case of an overdose of Tolbuterol HCl Syrup/Suspension, immediate symptoms may include rapid heart rate, tremors, nervousness, and headache. More severe effects can lead to seizures, cardiac arrhythmias, and even respiratory distress. It is crucial to seek medical assistance promptly, as the healthcare provider will determine the necessary treatment based on the severity of the symptoms, which may include monitoring vital signs, providing supportive care, and administering appropriate medications to counteract the overdose.

In the case of a missed dose of Tolbuterol HCl Syrup/Suspension, it is important to take the medication as soon as you remember. However, if it is almost time for the next scheduled dose, skip the missed dose and continue with your regular dosing schedule. Do not double the dose to make up for the missed one. If you miss several doses, contact your healthcare provider for guidance on how to safely resume the medication without compromising its effectiveness.

To take Tolbuterol HCl Syrup/Suspension, shake the bottle well, then use a measuring device like a marked measuring spoon or oral syringe to measure the prescribed dose, and administer it orally, following the instructions provided by your healthcare professional, typically taken twice or three times a day with or without food.

Here are the conditions or situations when Tolbuterol HCl Syrup/Suspension should not be used:

• Avoid use in individuals with a known allergy or hypersensitivity to Tolbuterol HCl or any of the excipients in the formulation.
• Contraindicated in patients with a history of severe cardiovascular diseases, including severe heart rhythm disorders (e.g., ventricular fibrillation, tachycardia), heart disease, or recent heart attack.
• Should not be used in individuals with uncontrolled high blood pressure.
• Not recommended for patients with severe lung diseases, such as severe chronic obstructive pulmonary disease (COPD) or asthma exacerbation.
• Avoid use in patients with low potassium levels (hypokalemia) or conditions that could worsen with low potassium.
• Contraindicated during active seizures or in patients with a history of seizures, as it may lower the seizure threshold.
• Should not be used in individuals with an overactive thyroid (hyperthyroidism).
• Not suitable for patients with a tumor of the adrenal gland (pheochromocytoma).
• Avoid use in individuals with diabetes, as it may increase blood sugar levels.
• Contraindicated in patients with a history of severe allergic reactions or anaphylaxis.

The side effects of Tolbuterol HCl Syrup/Suspension may include:

• Nervousness or anxiety
• Tremors or shaking
• Headache
• Dizziness or lightheadedness
• Nausea or vomiting
• Dry mouth or throat irritation
• Muscle cramps
• Rapid heart rate or palpitations

Following are the precautions and warnings for Tolbuterol HCl Syrup/Suspension:

• Do not use if you are allergic to Tolbuterol or any of the excipients in the medication.
• This medication may cause nervousness, restlessness, or tremors. If these symptoms occur, consult your doctor.
• Tolbuterol can cause serious heart-related side effects, including faster or uneven heart rate. Seek medical attention if you experience chest pain, rapid heartbeat, or difficulty breathing.
• Caution is advised in patients with heart disease, high blood pressure, or epilepsy as it may worsen these conditions.
• It may cause dizziness or lightheadedness. Avoid driving or operating machinery until you know how this medication affects you.
• Inform your doctor if you are pregnant, planning to become pregnant, or breastfeeding, as Tolbuterol may not be suitable in these cases.
• Keep this medication out of the reach of children. In case of accidental ingestion, seek medical help immediately.

Following are the drug interactions for Tolbuterol HCl Syrup/Suspension:

• Beta-blockers, such as propranolol, can reduce the effectiveness of Tolbuterol, as they block its stimulating effect on beta-2 receptors.
• Combining Tolbuterol with other sympathomimetic drugs (e.g., epinephrine, pseudoephedrine) may cause an excessive increase in heart rate and blood pressure.
• Anticholinergic medications may interact, potentially leading to increased side effects like dry mouth and constipation.
• The effect of Tolbuterol may be reduced when used with corticosteroids, as they can inhibit its bronchodilator action.
• Digoxin levels can be affected by Tolbuterol, requiring close monitoring to prevent potential toxicity.
• Caution is advised with diuretics, as Tolbuterol may decrease potassium levels, and concurrent use might enhance this effect.
• MAO inhibitors can interact with Tolbuterol, potentially causing hypertensive crisis and other serious side effects.

Following are the food interactions for Tolbuterol HCl Syrup/Suspension:

• Citrus fruits, particularly grapefruit and its juice, should be avoided as they can interfere with the metabolism of Tolbuterol, leading to increased drug levels and potential side effects.
• Caffeinated beverages should be limited as they may enhance the stimulant effects of Tolbuterol, causing increased heart rate and nervousness.
• Alcohol consumption should be minimized as it can exaggerate the dizziness and lightheadedness associated with Tolbuterol.
• Avoid high-fat meals as they may delay the absorption and onset of action of the medication.
• Dairy products like milk and yogurt can potentially decrease the absorption of Tolbuterol, so it's best to separate them by a few hours.
• Spicy foods may irritate the throat and stomach, especially when taking Tolbuterol, which can cause throat irritation as a side effect.
• Consuming potassium-rich foods like bananas and oranges is essential, as Tolbuterol can deplete potassium levels in the body.

Tolbuterol HCl Syrup/Suspension should be stored at controlled room temperature, between 20°C and 25°C (68°F to 77°F), in a dry place, away from direct sunlight and moisture. Keep the medication in its original container, tightly sealed, to maintain its integrity and prevent contamination. Do not expose it to freezing temperatures or excessive heat, as this can impact its effectiveness. Always check the expiration date, and properly dispose of any unused or expired syrup by following local guidelines or consulting a healthcare professional. Avoid flushing or pouring it down the drain. Keep the medication safely locked away from children to prevent accidental consumption.

Following are the quick tips for Tolbuterol HCl Syrup/Suspension:

• Consult your doctor for the correct dosage and usage instructions for effective treatment.
• Before use, shake the bottle vigorously to ensure a homogeneous mixture.
• Administer the syrup with a measuring cup or oral syringe for accurate dosing.
• Store the medication at room temperature, away from direct sunlight and moisture.
• Do not freeze the syrup, as it may affect its potency.
• Always check the expiration date before using the medication.
• Regularly monitor your health and consult your doctor if symptoms persist or worsen.
• Inform your healthcare provider about all medications you are taking to avoid potential drug interactions.