Brimo (0.2%) 5ml Eye Drops

Brimonidine, a highly selective alpha-2 adrenergic receptor agonist, works by activating these receptors in the eye's ciliary body. This activation leads to a decrease in aqueous humor production, which is primarily achieved through the activation of postsynaptic alpha-2 receptors. The reduction in aqueous humor production is believed to be mediated by decreased production of cyclic AMP via inhibition of adenylate cyclase. By reducing the amount of fluid produced within the eye, brimonidine helps lower intraocular pressure, making it effective in managing conditions like glaucoma and ocular hypertension.

Brimonidine

Alpha-adrenergic agonist.

Drop

The following are the uses of Brimonidine Drop:

• Used for reducing intraocular pressure in patients with open-angle glaucoma or ocular hypertension.
• Used to treat eye redness and dryness associated with ocular allergies.
• Used to prevent and treat certain eye conditions, such as corneal ulcers and conjunctivitis.
• Used for managing the symptoms of ocular rosacea, reducing redness and inflammation.
• Used to constrict blood vessels on the eye's surface, decreasing eye redness caused by minor eye irritations.
• Used to alleviate eye strain and fatigue, especially for those who spend long hours in front of digital screens.
• Used as a short-term treatment to change eye color, making the eyes appear darker.

To be used as per doctor's instructions

In the case of an overdose of Brimonidine Drops, it is important to recognize the potential severity of the situation. The eyes may experience heightened sensitivity, accompanied by a stinging or burning sensation. Additionally, symptoms such as dizziness, lightheadedness, and fatigue may manifest. Promptly seek medical advice or assistance to ensure appropriate management of the overdose and to prevent any potential adverse effects on the eyes or overall health.

In the case of a missed dose of Brimonidine eye drops, it is important to administer the missed dose as soon as you remember. However, if it is almost time for your next scheduled dose, it is best to skip the missed dose to avoid any potential side effects. Do not double the dose to make up for a missed one, as this may increase the risk of adverse reactions. If you frequently miss doses, consider setting reminders or using a pill organizer to help you stay on track with your medication schedule. Consult your healthcare provider if you have any concerns or questions about missed doses.

To use Brimonidine eye drops, gently tilt your head back, pull the lower eyelid down to create a pocket, and hold the dropper tip close to but not touching your eye, then squeeze out a single drop into the pocket, blinking gently to allow the drop to spread over the eye's surface.

Following are the conditions/situations when Brimonidine Drops should not be used:

• Should not be used if you have a known allergy or sensitivity to Brimonidine or any other ingredients in the eye drops.
• Contraindicated in patients with severe cardiovascular conditions, including uncontrolled high blood pressure, heart disease, or recent heart attack.
• Not suitable for individuals with severe kidney or liver disease.
• Avoid using Brimonidine drops if you have narrow-angle glaucoma or uveitis.
• Do not use if you have a history of severe allergic reactions or respiratory problems.
• Should not be used while wearing contact lenses.
• Contraindicated in patients with a history of depression or mental health disorders.
• Not recommended for infants, young children, or elderly patients without medical advice.
• Do not use Brimonidine drops if the solution is discolored or contains particles.

The side effects of Brimonidine Eye Drops may include:

• Stinging or burning sensation in the eyes
• Dry mouth
• Headache
• Fatigue and drowsiness
• Blurred vision or visual disturbances
• Redness or irritation of the eyes
• Itching or discomfort around the eye area
• Allergic reactions (rare)

Following are the precautions and warnings:

• Brimonidine Eye Drops should not be used by individuals with a known allergy or sensitivity to brimonidine tartrate or any of the other ingredients in the eye drops.
• These drops are for ophthalmic use only and should never be taken orally or injected.
• Patients with a history of cardiovascular diseases, such as low or high blood pressure, should use Brimonidine Drops with caution as they may affect blood pressure.
• It may cause drowsiness or blurred vision, so patients should avoid driving, operating heavy machinery, or performing tasks that require clear vision until they know how the medication affects them.
• Contact lens wearers should remove their lenses before administering the eye drops and wait at least 15 minutes after use before reinserting them to prevent contamination.
• Brimonidine Drops should be used with caution in children and elderly patients as they may be more sensitive to its effects.
• If you have a history of corneal diseases or any other eye conditions, consult your doctor before using these drops.
• Do not exceed the recommended dosage, as it may lead to increased eye redness and other adverse effects.

Following are the drug interactions for Brimonidine Drops:

• Alcohol-based eye solutions can cause stinging or burning. Avoid using such solutions while using Brimonidine.
• Brimonidine may interact with other alpha-2 adrenergic agonists, leading to increased risk of systemic effects and hypotension.
• Drugs affecting the Cytochrome P450 enzyme system (e.g., rifampin, carbamazepine) can alter Brimonidine's metabolism.
• The use of beta-blockers with Brimonidine may result in additive effects on blood pressure and heart rate.
• Antihypertensive medications Brimonidine may enhance the effects of these drugs, causing excessive hypotension.
• Clonidine and other centrally acting alpha-2 agonists can have additive effects when used with Brimonidine.
• Caution is advised with drugs that cause mydriasis (dilation of the pupil), as Brimonidine's effect may be reduced.

Following are the food interactions for Brimonidine Drops:

• Avoid consuming alcohol during the use of Brimonidine as it can increase the risk of side effects like dizziness and drowsiness.
• Grapefruit and its juice should be avoided as they may increase the concentration of Brimonidine in the body, leading to potential adverse effects.
• Caffeine intake should be monitored as it can increase blood pressure, counteracting the effects of Brimonidine which aims to reduce eye pressure.
• Avoid excessive salt consumption as it can lead to fluid retention, potentially affecting eye pressure and reducing the medication's effectiveness.
• A well-balanced diet with limited saturated fats and trans fats is recommended to support overall eye health.
• Staying hydrated by drinking adequate water is essential for maintaining eye moisture and comfort.
• Consuming foods rich in antioxidants, such as leafy greens and berries, may provide additional benefits for eye health.
• Certain fish like salmon, rich in omega-3 fatty acids, can contribute to maintaining healthy eyes.

Brimonidine Drops should be stored in a cool and dry place, preferably at room temperature, ensuring it is kept away from direct sunlight, heat, and moisture. It is crucial to keep the bottle tightly sealed to maintain its integrity and prevent contamination. Always check the expiration date before using the medication, and dispose of any unused or expired drops with caution. Do not dispose of them by flushing or pouring them down the drain; instead, seek advice from a pharmacist or healthcare professional for appropriate disposal methods. Remember to keep the medication out of children's reach to prevent accidental ingestion.

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Following are the quick tips for Brimonidine Drops:

• Wash your hands thoroughly before administering the drops to maintain hygiene.
• Tilt your head back, look upwards, and gently pull down your lower eyelid to create a pocket.
• Hold the dropper close to your eye, without touching it, and squeeze out the prescribed number of drops into the pocket.
• Close your eyes gently and apply light pressure to the inner corner of your eye for 1-2 minutes to prevent drainage.
• Avoid blinking rapidly or rubbing your eyes after instilling the drops for better absorption.
• If you use other eye medications, wait at least 5-10 minutes before applying the next medication to prevent washout.
• Store the drops at room temperature, away from direct sunlight and moisture.