BRIVERA (25MG) TAB 14 TABLETS

Brivaracetam's primary mechanism of action is as a selective ligand for synaptic vesicle protein 2A (SV2A), which is involved in the regulation of synaptic vesicle exocytosis and neurotransmitter release. It binds to SV2A with high affinity, leading to a reduction in the release of excitatory neurotransmitters, particularly glutamate. This modulation of neurotransmitter release is believed to contribute to its anticonvulsant effects. Brivaracetam's interaction with SV2A is thought to stabilize neuronal membranes, reduce neuronal hyperexcitability, and decrease the propagation of seizure activity, thereby preventing or reducing the frequency of seizures.

Brivaracetam 25mg

Anticonvulsant

Tablet

The following are the uses of Brivaracetam 25mg Tablet:

• Used for treating partial-onset seizures in adults, adolescents, and children.
• Used to manage seizures associated with Lennox-Gastaut syndrome.
• Used as an add-on therapy to control seizures when other medications are not fully effective.
• Used to improve seizure control and reduce seizure frequency.
• Used for its ability to enhance synaptic transmission and stabilize neuronal hyperexcitability.
• Used for its unique mechanism of action, targeting specific receptors in the brain.
• Used as part of a comprehensive treatment plan for epilepsy management.

To be taken as per doctor's prescription

In the case of an overdose of Brivaracetam 25mg Tablets, it is important to recognize the potential symptoms and seek medical assistance promptly. Overdose symptoms may include extreme drowsiness, confusion, and impaired coordination. If you suspect an overdose, contact a healthcare professional or poison control center immediately. They will provide guidance on the necessary steps, which may include immediate medical evaluation and potential treatment to manage the overdose effectively.

In the case of a missed dose of Brivaracetam 25mg Tablet, it is important to take the missed dose as soon as you remember. However, if it is almost time for your next scheduled dose, skip the missed dose and continue with your regular dosing schedule. Do not take a double dose to make up for a missed one. If you miss multiple doses, contact your healthcare professional for advice on how to safely resume your medication regimen without compromising its effectiveness. It is crucial to maintain a consistent medication routine for optimal therapeutic benefits.

To take Brivaracetam 25mg Tablet, swallow the tablet whole with a glass of water, as directed by your healthcare provider, typically twice a day, and follow the prescribed dosage and schedule provided by your doctor.

Following are the conditions/situations when Brivaracetam 25mg Tablet should not be used:

• Should not be taken if you are allergic to brivaracetam or any other medications similar to it.
• Not suitable for individuals with a history of severe kidney problems.
• Contraindicated in patients with a rare genetic problem of galactose intolerance, severe lactase deficiency, or glucose-galactose malabsorption.
• Should not be used if you have a history of hypersensitivity reactions to inactive ingredients present in the medication.
• Not recommended for patients with a history of severe respiratory conditions or breathing problems.

The side effects of Brivaracetam 25mg Tablet may include:

• Dizziness
• Fatigue or tiredness
• Nausea and vomiting
• Headache
• Sleepiness or drowsiness
• Coordination problems
• Balance disorders
• Irritability

Following are the precautions and warnings for Brivaracetam 25mg Tablet:

• Do not start or stop this medication without consulting your doctor, as sudden changes in dosage may lead to seizures.
• Regular monitoring of liver function is essential during treatment, especially in patients with pre-existing liver conditions.
• Patients with a history of kidney disease should exercise caution and inform their doctor, as dosage adjustments might be necessary.
• Brivaracetam may cause dizziness or drowsiness; patients should avoid driving or operating heavy machinery until they know how the medication affects them.
• Elderly patients may be more susceptible to side effects; close monitoring is advised for this age group.
• If you have a history of mental health disorders, discuss it with your doctor, as this medication may cause mood changes.
• Consult your doctor if you are pregnant, planning to become pregnant, or breastfeeding before taking Brivaracetam.
• Keep this medication out of reach of children and pets, and store it in a cool, dry place as directed.

Following are the drug interactions for Brivaracetam 25mg Tablet:

• Avoid using carbamazepine, phenobarbital, phenytoin, or primidone, as these may reduce the effectiveness of brivaracetam.
• Ethinyl estradiol and levonorgestrel, when used with brivaracetam, can lead to decreased plasma concentrations of these hormones.
• Hormonal contraceptives may not work effectively with brivaracetam, potentially reducing their effectiveness.
• Brivaracetam can increase the plasma concentrations of digoxin, requiring careful monitoring.
• Drugs that cause sedation, such as benzodiazepines or opioids, may have enhanced effects when used with brivaracetam.
• It can interact with other anticonvulsants like phenytoin, carbamazepine, and phenobarbital, altering their levels.
• The effectiveness of brivaracetam may be reduced by strong CYP2C19 inducers, such as rifampin.
• Brivaracetam may decrease the effectiveness of warfarin, requiring close monitoring of INR.

Following are the food interactions for Brivaracetam 25mg Tablet:

• Grapefruit and grapefruit juice should be consumed with caution as they may alter the effectiveness of Brivaracetam due to the potential inhibition of certain enzymes in the liver.
• Alcohol intake should be minimized or avoided as it can enhance the sedative effects of the medication, increasing the risk of dizziness and impaired coordination.
• Fatty or high-fat meals may slightly delay the absorption of Brivaracetam, but this is generally not considered a significant interaction.
• Avoid excessive caffeine consumption as it may counteract the calming effects of Brivaracetam and potentially increase nervousness or anxiety.
• Avoid eating large amounts of chocolate, as it contains compounds that can inhibit certain enzymes and potentially interact with Brivaracetam's metabolism.
• No specific dietary restrictions are required, but maintaining a balanced diet is recommended for overall health.
• Always inform your healthcare provider about your dietary habits to ensure the medication's optimal effectiveness.
• Stay well-hydrated, especially when taking this medication, to support overall kidney and liver function.

Brivaracetam 25mg Tablets should be stored in a cool and dry place, preferably at room temperature, ensuring it remains protected from direct sunlight, moisture, and heat. Keep the tablets in their original packaging, tightly sealed, to maintain their integrity and prevent exposure to environmental factors. It is crucial not to store the medication in bathrooms or near heat-emitting appliances. Regularly check the expiration date, and if the tablets are expired or no longer needed, do not flush them or dispose of them in regular household waste. Contact your pharmacist or healthcare provider for guidance on safe disposal methods to minimize environmental impact and prevent unauthorized access. Keep the medication away from children to prevent accidental ingestion.

No

Following are the quick tips for Brivaracetam 25mg Tablet:

• Ensure you take the medication as directed by your doctor for effective treatment.
• Take the tablet with a full glass of water for easy swallowing.
• Maintain a consistent daily routine for taking the medication.
• Avoid missing doses; set reminders if needed.
• Consult your doctor if you experience any unusual symptoms.
• Store the medication in a cool, dry place, away from direct sunlight.
• Do not share your medication with others, even if they have similar symptoms.