Brolene (0.1%) 10ml Eye Drops

Propamidine, the active ingredient in PROPAMIDINE drops, acts as a broad-spectrum antimicrobial agent. It exerts its mechanism of action by interfering with the synthesis of DNA and RNA in microbial cells. Propamidine binds to the minor groove of DNA, primarily targeting the DNA of parasites and certain bacteria, which ultimately leads to the inhibition of nucleic acid synthesis, disrupting vital cellular processes and resulting in the death of the microorganism. This selective action makes propamidine effective against a range of pathogens, particularly those causing eye infections.

Antiseptic/disinfectant.

Drop

The following are the uses of PROPAMIDINE Drop:

• Used for treating fungal infections of the skin and nails
• Used for its broad-spectrum antifungal properties
• Used for managing superficial skin infections
• Used for controlling the spread of fungal growth
• Used for alleviating itching and irritation associated with fungal conditions
• Used for promoting healing and restoring skin health
• Used for its effectiveness against a variety of fungi, including yeasts and molds
• Used for providing targeted relief from fungal-related discomfort

In the case of an overdose of PROPAMIDINE Drops, the primary concern is the potential for increased side effects and toxicity. Symptoms may include severe skin irritation, redness, and burning at the application site. In more severe cases, there could be systemic effects such as nausea, vomiting, and dizziness. Promptly seek medical advice and treatment to manage any adverse reactions. Ensure that you provide the healthcare professional with information about the product and the amount ingested or applied.

In the case of a missed dose of PROPAMIDINE Drops, it is important not to panic. Simply administer the missed dose as soon as you remember. However, if it is almost time for your next scheduled dose, skip the missed one and continue with your regular dosing schedule. Do not apply a double dose to make up for a missed one, as this may increase the risk of side effects. If you frequently forget doses, consider setting reminders or asking someone to help you remember.

To use PROPAMIDINE drops, gently tilt your head back, instill the prescribed number of drops into the affected eye(s) as directed by your healthcare provider, and then close your eyes for a few minutes to allow the medication to be absorbed.

Following are the conditions or situations when PROPAMIDINE Eye Drops should not be used:

• Avoid using PROPAMIDINE if you have a known allergy or sensitivity to propamidine or any other ingredients in the eye drops.
• Do not use if you have a history of severe eye infections or eye injuries without consulting an eye specialist.
• Contraindicated for individuals with eye conditions such as glaucoma or untreated dry eye syndrome.
• Not suitable for those who have a history of corneal ulcers or severe corneal damage.
• Should not be used if you have a foreign object in your eye or any eye condition requiring surgical intervention.
• Avoid using these eye drops if you are currently using other eye medications without consulting a healthcare professional.
• Do not administer to infants or very young children without medical advice.

The side effects of PROPAMIDINE Drop may include:

• Allergic reactions • skin rash, itching, or hives.
• Irritation or burning sensation at the application site.
• Redness or swelling of the eyelids.
• Temporary blurred vision or eye discomfort.
• Dryness or excessive tearing in the eyes.
• Headache or dizziness.
• Sensitivity to light.

Following are the precautions and warnings for PROPAMIDINE Drops:

• This medication is for external use only. Avoid contact with eyes, mouth, and broken skin.
• Wash your hands thoroughly before and after application to prevent contamination.
• Do not use PROPAMIDINE if you are allergic to any of its ingredients. Always check the product information for potential allergens.
• If you are using PROPAMIDINE near the eyes, exercise extreme caution to prevent eye irritation. If eye contact occurs, rinse thoroughly with water.
• Discontinue use and consult a healthcare professional if you experience any unusual symptoms, such as severe burning, stching, or skin irritation.
• Keep out of reach of children. Store in a cool, dry place, away from direct sunlight.
• Consult a healthcare professional for proper use and dosage instructions, especially for children and elderly individuals.

Following are the drug interactions for PROPAMIDINE Drops:

• PROPAMIDINE may interact with other topical medications, especially those containing silver, causing discoloration or reduced effectiveness.
• Concomitant use with other antiseptic or disinfectant agents should be avoided to prevent skin irritation.
• Drug interactions may occur with systemic medications, such as sulfonamides, as PROPAMIDINE can be absorbed through the skin.
• It may increase the effects of other ophthalmic medications if used concurrently.
• The use of PROPAMIDINE with other eye drops containing preservatives can lead to increased ocular irritation.
• Caution is advised when using PROPAMIDINE with contact lenses, as it may cause lens discoloration or reduced visibility.
• Topical anesthetics should be used with caution, as PROPAMIDINE may enhance their absorption and increase systemic effects.

Following are the food interactions for Propamidine Drops:

• Avoid consuming alcohol during the treatment period as it may increase the risk of side effects and affect the overall effectiveness of the medication.
• Grapefruit and its juice should be avoided as they can interfere with the metabolism of the drug, potentially leading to increased levels of Propamidine in the body.
• Dairy products like milk, cheese, and yogurt might reduce the absorption of Propamidine, so consider taking the medication at least 1-2 hours before or after consuming dairy.
• Foods high in fat may slow down the absorption of Propamidine, so it is best to take the medication on an empty stomach or at least 2 hours after a high-fat meal.
• Avoid spicy foods as they can irritate the throat and mouth, especially if you are experiencing mouth sores or inflammation as a side effect of the medication.
• Citrus fruits like oranges, lemons, and tomatoes may cause a stinging sensation in the mouth, so it's advisable to avoid them while using Propamidine Drops.
• Avoid hot beverages like coffee and tea immediately after using the drops, as they might rinse away or dilute the medication, reducing its effectiveness.
• Propamidine Drops should be taken after meals to minimize potential stomach upset and increase the drug's absorption.

PROPAMIDINE Drop should be stored in a cool, dry place, preferably at room temperature between 20-25°C (68-77°F). Keep the bottle tightly closed and protected from light. Avoid freezing or exposing the drops to excessive heat. Do not use the drops if they have changed color or become cloudy. Dispose of the medication properly by returning it to a pharmacy or healthcare facility for safe disposal, ensuring it is out of the reach of children and pets. Do not pour the drops down the sink or flush them down the toilet, as this can cause environmental harm. Always follow local guidelines for pharmaceutical waste disposal.

Following are the quick tips for PROPAMIDINE Drops:

• Wash your hands before using the eye drops to maintain hygiene.
• Tilt your head back, gently pull down your lower eyelid, and instill the prescribed number of drops into the eye.
• Avoid touching the dropper tip to your eye or any surface to prevent contamination.
• Close your eye gently after instilling the drops and apply light pressure to the inner corner of the eye to minimize drainage.
• If you are using other eye medications, wait at least 5 minutes before applying the next medication.
• Store the eye drops at room temperature, away from direct sunlight and heat.
• Do not use the drops if the solution changes color or becomes cloudy.