Brolene (0.15%) 5g Eye Ointment

DIBROMOPROPAMIDINE Ointment, a topical antimicrobial agent, exerts its effect through the active ingredient dibromopropamidine. This compound disrupts the cell wall synthesis of bacteria, primarily targeting gram-positive bacteria such as Staphylococcus aureus and Streptococcus pyogenes. It binds to the negatively charged phospholipids in the bacterial cell wall, causing the cell wall to become permeable and ultimately leading to bacterial cell death. The mechanism involves inhibiting the production of peptidoglycan, a vital component of the bacterial cell wall, thereby weakening the structural integrity of the bacteria and preventing their proliferation.

DIBROMOPROPAMIDINE

Antibacterial Ointment

Ointment

The following are the uses of DIBROMOPROPAMIDINE Ointment:

• Used for treating superficial bacterial skin infections
• Used for preventing bacterial growth and spread on the skin
• Used for minor cuts, scrapes, and wounds to prevent infection
• Used for reducing the risk of infection in minor skin surgeries or procedures
• Used for managing skin infections caused by sensitive bacteria
• Used for soothing skin irritations and promoting healing
• Used for maintaining skin hygiene in high-risk environments
• Used for adjunctive therapy in comprehensive skin care regimens

In the case of an overdose of DIBROMOPROPAMIDINE Ointment, it is important to seek medical advice promptly. Symptoms may include skin irritation, redness, and itching at the application site. Rinse the affected area thoroughly with water and avoid further application. Contact a healthcare professional or go to the nearest emergency department for appropriate treatment and guidance, especially if any adverse reactions occur.

In the case of a missed dose of DIBROMOPROPAMIDINE Ointment, it is important to apply the medication as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue with your regular schedule. Do not apply extra ointment to make up for the missed dose. If you miss multiple doses, contact your healthcare provider for guidance on how to resume the treatment and ensure the best outcome. Always keep a consistent routine to avoid missing doses in the future.

To apply DIBROMOPROPAMIDINE Ointment, clean and dry the affected area, then gently apply a thin layer of the ointment to the skin, following the instructions provided by your healthcare professional, typically twice a day or as directed.

Here are the conditions and situations when DIBROMOPROPAMIDINE Ointment should not be used:

• Avoid using if you have a known allergy or sensitivity to dibromopropamidine or any other ingredients in the ointment.
• Do not apply to open wounds, broken skin, or severe burns.
• Not suitable for use in the eyes or on mucous membranes.
• Do not use if you are experiencing extensive skin damage or severe skin conditions.
• Discontinue use and consult a doctor if you experience severe irritation, redness, or swelling at the application site.
• Not recommended for infants or young children without medical advice.

The side effects of DIBROMOPROPAMIDINE Ointment may include:

• Skin irritation or redness at the application site
• Itching or burning sensation
• Dryness of the skin
• Allergic reactions such as rashes or hives
• Swelling of the face, lips, or tongue
• Difficulty breathing
• Severe dizziness or lightheadedness
• Prolonged or excessive use may lead to skin thinning or discoloration.

Following are the precautions and warnings for DIBROMOPROPAMIDINE Ointment:

• Avoid contact with eyes, nose, and mouth. In case of accidental contact, immediately rinse with water.
• Do not apply to broken or irritated skin. Seek medical attention if irritation persists.
• Wash your hands thoroughly before and after applying the ointment to prevent the spread of infection.
• Do not cover the treated area with bandages or tight clothing, as this may increase the risk of skin irritation.
• Inform your healthcare provider if you have any pre-existing skin conditions or are using other topical medications to avoid potential interactions.
• Keep the ointment out of reach of children and pets. Store it in a cool, dry place away from direct sunlight.
• Discontinue use and consult a healthcare professional if you experience severe or persistent side effects, such as skin redness, swelling, or burning.

Following are the drug interactions for Dibromopropamidine Ointment:

• Dibromopropamidine may interact with other topical medications containing silver or heavy metals, potentially reducing the effectiveness of both agents.
• Avoid using other antiseptic or disinfectant products simultaneously, as this may lead to skin irritation or altered wound healing.
• The use of other antimicrobial ointments or creams on the same area can result in decreased absorption and reduced efficacy of both medications.
• Topical corticosteroids, when used with Dibromopropamidine, may mask infection symptoms and delay proper treatment.
• Some local anesthetics, if applied topically with Dibromopropamidine, can increase the risk of skin sensitization and allergic reactions.
• Photosensitizing drugs, when combined with Dibromopropamidine, may increase the risk of sunburn and skin damage from UV light exposure.
• Be cautious when using Dibromopropamidine with other medications that cause dry skin, as this may exacerbate skin irritation.

Following are the food interactions to consider with DIBROMOPROPAMIDINE Ointment:

• Avoid applying the ointment immediately after consuming spicy foods, as it may cause temporary skin irritation or sensitivity.
• It is generally safe to use DIBROMOPROPAMIDINE Ointment while consuming most foods, as the active ingredients have low systemic absorption.
• Avoid using the ointment on areas with food residue, as it should be applied to clean, dry skin for optimal effectiveness.
• There is no known interaction with specific food types, but maintaining a balanced diet is advisable for overall health.
• Caffeine intake should be monitored, as excessive consumption might affect skin hydration, potentially impacting the treated area.
• Ensure you wash your hands thoroughly after handling spicy or acidic foods before applying the ointment to avoid any potential discomfort.
• The ointment's effectiveness is not influenced by dietary choices, allowing for flexibility in food choices during treatment.

The proper storage and disposal of DIBROMOPROPAMIDINE Ointment are essential to maintain its effectiveness and ensure safety. Store the ointment at room temperature, away from excessive heat, direct sunlight, and moisture. Keep it in its original container, tightly sealed, to prevent contamination and maintain its integrity. Avoid storing it in the bathroom or near heat-emitting appliances. Regularly check the expiration date, and do not use the ointment if it has expired. For disposal, do not flush or pour the ointment down the drain. Contact your local pharmacist or healthcare provider for instructions on proper disposal methods to protect the environment and prevent misuse. Keep the ointment securely stored, out of the reach of children and pets, to prevent accidental exposure.

Following are the quick tips for Dibromopropamidine Ointment:

• Wash your hands thoroughly before applying the ointment to ensure a clean application.
• Clean the affected area gently, pat dry, and then apply a thin layer of ointment as directed.
• Avoid applying the ointment on broken skin or open wounds.
• Do not cover the treated area with a bandage unless instructed by your healthcare provider.
• For external use only; do not ingest or apply near the eyes or mouth.
• Store the ointment at room temperature, away from direct sunlight and moisture.
• Consult your healthcare provider if symptoms persist or worsen after using the ointment for a few days.