Broncophyline (125mg/5ml) 120ml Syrup

Acefylline Piperazine, the active ingredient in the syrup/suspension, primarily acts as a bronchodilator and respiratory stimulant. It is a derivative of theophylline, a xanthine compound. Acefylline Piperazine works by inhibiting phosphodiesterase enzymes, leading to increased levels of cyclic adenosine monophosphate (cAMP) in the body. This elevation in cAMP relaxes bronchial smooth muscles, resulting in bronchodilation and improved airflow to the lungs. Additionally, it stimulates the respiratory center in the brain, enhancing respiratory function. The medication's mechanism of action contributes to its effectiveness in treating respiratory conditions by promoting easier breathing and alleviating symptoms associated with respiratory distress.

Acefylline Piperazine 125mg/5ml

Bronchodilator, Xanthine Derivative

Suspension

The following are the uses of Acefylline Piperazine 125mg/5ml Syrup/Suspension:

• Used for treating respiratory conditions such as chronic bronchitis and asthma, to relax and open up the airways.
• Used for reducing inflammation and mucus production in the lungs.
• Used for improving breathing and reducing coughing fits.
• Used for managing symptoms of COPD (Chronic Obstructive Pulmonary Disease) and other chronic lung disorders.
• Used for relieving chest tightness and shortness of breath.
• Used for preventing bronchospasms triggered by exercise or allergens.
• Used for providing symptomatic relief in respiratory infections.

To be used as per doctor's prescription

In the case of an overdose of Acefylline Piperazine 125mg/5ml Syrup/Suspension, symptoms may include nausea, vomiting, rapid heartbeat, and seizures. Immediate medical intervention is necessary, and individuals should seek emergency care without delay. It is important to monitor vital signs and provide supportive care until professional help arrives. Timely treatment can effectively manage and mitigate the adverse effects of the overdose.

In the case of a missed dose of Acefylline Piperazine 125mg/5ml Syrup/Suspension, it is important to administer the medication as soon as you remember. If it is almost time for the next dose, skip the missed dose and resume your regular dosing schedule. However, if the missed dose is remembered within a few hours of the scheduled time, it is generally safe to give the medication. Always ensure that you do not double the dose to make up for a missed one, as this may lead to an overdose. Consult your healthcare provider if you have any concerns or questions regarding missed doses.

To administer Acefylline Piperazine 125mg/5ml Syrup/Suspension, shake the bottle thoroughly, measure the prescribed dose with an accurate measuring device, and administer it orally, following the dosage instructions provided by your healthcare professional, typically once or twice daily, regardless of mealtimes.

Following are the conditions when Acefylline Piperazine 125mg/5ml Syrup/Suspension should not be used:

• Not suitable for individuals with a known allergy or hypersensitivity to Acefylline or other xanthine derivatives.
• Contraindicated in patients with severe cardiac arrhythmias, as it may worsen the condition.
• Should not be used in individuals with severe liver or kidney disease.
• Not recommended for patients with a history of peptic ulcer disease or gastrointestinal bleeding.
• Contraindicated in patients with a history of seizures or epilepsy.
• Should be avoided in individuals with pheochromocytoma.
• Not suitable for patients with a history of severe allergic reactions or anaphylaxis.
• Should not be used in patients with acute myocardial infarction.

The side effects of Acefylline Piperazine 125mg/5ml Syrup/Suspension may include:

• Nausea and vomiting
• Stomach pain or cramps
• Diarrhea
• Headache
• Dizziness or lightheadedness
• Sleep disturbances (insomnia or drowsiness)
• Increased heart rate or palpitations
• Allergic reactions (skin rash, itching, swelling)

Following are the precautions and warnings for Acefylline Piperazine 125mg/5ml Syrup/Suspension:

• Allergic reactions may occur; seek medical attention if you experience rash, itching, swelling, or difficulty breathing.
• This medication may cause dizziness; avoid driving or operating heavy machinery until you know how it affects you.
• Patients with heart conditions, high blood pressure, or liver disease should use with caution and under medical supervision.
• Avoid alcohol consumption while taking this medication as it may intensify side effects.
• Inform your doctor about all medications you are currently taking to prevent potential drug interactions.
• Do not exceed the prescribed dosage, as it may lead to serious health complications.
• Keep out of reach of children and pets; store in a cool, dry place.
• Consult your healthcare provider if you have any pre-existing medical conditions or are taking other medications.

Following are the drug interactions for Acefylline Piperazine 125mg/5ml Syrup/Suspension:

• May interact with xanthine oxidase inhibitors like allopurinol, increasing the risk of side effects related to xanthine accumulation.
• It can enhance the effects of other bronchodilators, such as theophylline, and may lead to increased heart rate and excitability.
• Acefylline may reduce the effectiveness of beta-blockers, a class of medications used to treat high blood pressure and heart conditions.
• Concomitant use with anticoagulants could potentially increase the risk of bleeding.
• It may also interact with certain antibiotics, such as erythromycin, potentially affecting the metabolism of both drugs.
• Caution is advised when combining with insulin or oral hypoglycemic agents, as it may affect blood glucose levels.
• Acefylline can increase the risk of arrhythmias when used with antiarrhythmic medications.

Following are the food interactions for Acefylline Piperazine 125mg/5ml Syrup/Suspension:

• Caffeine-containing foods and beverages should be limited as Acefylline is a methylxanthine derivative, and excessive caffeine intake may lead to increased side effects like jitteriness, anxiety, and insomnia.
• Avoid high-fat meals as they may delay the absorption of Acefylline, potentially affecting its therapeutic efficacy.
• Grapefruit and grapefruit juice should be avoided as they can interfere with the metabolism of Acefylline, leading to increased blood levels and potential side effects.
• Alcohol may increase the risk of side effects such as stomach upset and dizziness, so it's best to consume it in moderation or avoid it during treatment.
• Dairy products may decrease the absorption of Acefylline, so consider separating milk or yogurt intake from medication by a few hours.
• Maintain a balanced diet rich in fruits, vegetables, and whole grains to support overall health and minimize potential drug-nutrient interactions.
• Always consult your healthcare provider for personalized advice on managing food interactions with Acefylline treatment.

Acefylline Piperazine 125mg/5ml Syrup/Suspension should be stored in a secure and controlled environment, preferably in a locked cabinet or storage area, to ensure it remains inaccessible to unauthorized individuals. Maintain a cool and dry storage location, ideally at room temperature, to preserve the integrity of the medication. Protect the syrup from direct sunlight, heat, and moisture, as these factors can degrade its quality. Keep the syrup in its original container, tightly sealed, to prevent contamination and maintain its effectiveness. Dispose of any unused or expired medication responsibly; do not flush it down the toilet or pour it into drains. Contact your pharmacist or healthcare provider for guidance on proper disposal methods. It is crucial to store the medication safely, away from children, to prevent accidental consumption.

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Following are the quick tips for Acefylline Piperazine 125mg/5ml Syrup/Suspension:

• Follow the prescribed dosage and duration as advised by your doctor.
• Shake the bottle well before each use to ensure proper mixing.
• Administer the syrup with a measuring cup or oral syringe for accurate dosing.
• Take the syrup orally, and avoid mixing it with other beverages for best results.
• Store the medication at room temperature, away from moisture and direct sunlight.
• Do not freeze the syrup, as it may affect its potency.
• Regularly monitor your condition and inform your doctor if symptoms persist or worsen.