Brophyl-D (45/8mg/5ml) 120ml Syrup

Acefylline Piperazine, a xanthine derivative, acts as a bronchodilator by relaxing the smooth muscles in the airways. It achieves this by inhibiting phosphodiesterase enzymes, leading to increased intracellular cAMP levels, which subsequently relaxes bronchial smooth muscles. Diphenhydramine, an antihistamine, blocks the H1 histamine receptors, preventing the actions of histamine, thereby reducing allergic responses and suppressing the cough reflex.

Acefylline Piperazine 45mg/5ml, Diphenhydramine 8mg/5ml

Antitussive antihistamine combination

Suspension

The following are the uses of Acefylline Piperazine 45mg/5ml, Diphenhydramine 8mg/5ml Syrup/Suspension:

• Used for treating allergic reactions and relieving symptoms like sneezing, itching, and hives.
• Used for managing acute allergic reactions and anaphylaxis.
• Used for reducing inflammation and congestion in the upper respiratory tract.
• Used for providing short-term relief from acute asthma symptoms.
• Used for suppressing coughs associated with allergies or respiratory infections.
• Used for treating motion sickness and vertigo by reducing nausea and dizziness.
• Used for managing insomnia and promoting sleep in cases of allergies or respiratory conditions.
• Used for its bronchodilator effect, relaxing the airways to improve breathing.

In the case of an overdose of Acefylline Piperazine 45mg/5ml and Diphenhydramine 8mg/5ml Syrup/Suspension, prompt medical intervention is necessary. Symptoms may include severe nausea, vomiting, rapid heartbeat, confusion, and seizures. Immediate treatment should focus on stabilizing vital signs, providing respiratory support if needed, and managing any cardiovascular complications. Medical professionals should closely monitor patients and administer appropriate supportive care to ensure a safe recovery.

In the case of a missed dose of Acefylline Piperazine 45mg/5ml, administer the missed dose as soon as you remember, but if it is almost time for the next dose, skip the missed one. For Diphenhydramine 8mg/5ml, if a dose is missed, take it as soon as possible, but skip it if it's near the time for the next dose. Do not double the dose to make up for a missed one for either medication. If you miss multiple doses, consult your healthcare provider for guidance on how to safely resume the medication schedule.

To administer Acefylline Piperazine 45mg/5ml and Diphenhydramine 8mg/5ml syrup/suspension, shake the bottle well, and then use the provided measuring device to draw out the prescribed amount, ensuring you accurately measure 45mg of Acefylline Piperazine and 8mg of Diphenhydramine per 5ml, as directed by your healthcare provider.

Following are the conditions or circumstances when Acefylline Piperazine 45mg/5ml, Diphenhydramine 8mg/5ml Syrup/Suspension should not be taken:

• Should not be used in individuals with a known allergy to Acefylline Piperazine, Diphenhydramine, or similar medications.
• Avoid in patients with narrow-angle glaucoma or urinary retention.
• Contraindicated in patients with a history of hypersensitivity reactions to any of the components in the syrup.
• Not suitable for individuals with severe cardiovascular disease or hypertension.
• Should not be used in patients with severe liver or kidney impairment.
• Avoid using in children below 2 years of age.
• Contraindicated during breastfeeding as it may pass into breast milk.
• Do not use if you have a history of seizures or epilepsy.

The side effects of Acefylline Piperazine 45mg/5ml and Diphenhydramine 8mg/5ml Syrup/Suspension may include:

• Nausea and vomiting
• Dizziness or lightheadedness
• Dry mouth and throat
• Sedation or drowsiness
• Blurred vision or difficulty focusing
• Constipation
• Increased heart rate or palpitations
• Allergic reactions (such as rash, itching, or difficulty breathing)

Following are the precautions and warnings for Acefylline Piperazine 45mg/5ml, Diphenhydramine 8mg/5ml Syrup/Suspension:

• This medication should be used with caution in patients with a history of gastrointestinal ulcers or bleeding, as it may worsen these conditions.
• Patients with cardiovascular diseases, such as hypertension or heart arrhythmias, should be closely monitored due to the potential cardiovascular effects of acefylline.
• Not recommended for individuals with a known allergy to piperazine derivatives or diphenhydramine.
• Caution is advised in patients with liver impairment, as the metabolism of the medication may be altered.
• Avoid alcohol consumption while using this medication, as it may increase the risk of side effects.
• Do not exceed the recommended dosage, as it may lead to severe adverse reactions.
• Store the medication out of reach of children and at room temperature, away from direct sunlight.

Following are the drug interactions for Acefylline Piperazine 45mg/5ml, Diphenhydramine 8mg/5ml Syrup/Suspension:

• Alcohol and other central nervous system (CNS) depressants may have additive effects, leading to increased sedation and impaired motor skills.
• Antihistamines can reduce the clearance of Acefylline, potentially increasing its concentration in the body.
• Acefylline may decrease the effectiveness of Diphenhydramine in treating allergic reactions.
• Concomitant use with other xanthine derivatives (e.g., theophylline) may increase the risk of adverse effects such as nausea, vomiting, and arrhythmias.
• Diphenhydramine can potentiate the effects of CNS depressants and opioids, requiring dosage adjustments.
• It may reduce the effectiveness of certain antihypertensive medications.
• Caution is advised when combining with anticholinergic drugs, as it may increase the risk of side effects like dry mouth, blurred vision, and urinary retention.
• Some antibiotics may interact with Acefylline, affecting its metabolism and efficacy.

Following are the food interactions for Acefylline Piperazine 45mg/5ml, Diphenhydramine 8mg/5ml Syrup/Suspension:

• Grapefruit and grapefruit juice should be avoided as they can interfere with the breakdown of Diphenhydramine, potentially leading to increased side effects.
• Alcohol consumption should be minimized or avoided as it can add to the sedative effects of Diphenhydramine, causing enhanced drowsiness and impaired coordination.
• Caffeine-rich foods and beverages, like coffee, tea, and energy drinks, should be limited as they can counteract the sedative effect of Diphenhydramine, making it less effective.
• Consuming high-fat meals might slightly delay the absorption of Acefylline Piperazine, but it won't significantly impact its overall effectiveness.
• It is generally recommended to take the medication with a full glass of water to ensure proper administration and reduce the risk of irritation to the throat and stomach.
• Avoid consuming excessive amounts of dairy products, as calcium-rich foods might slightly reduce the absorption of Diphenhydramine.
• Spicy foods should be approached with caution as they can potentially irritate the stomach, especially when combined with medications.
• Always ensure you follow the dosage instructions provided by your healthcare professional, and if you have any specific dietary concerns, consult your doctor or pharmacist.

Acefylline Piperazine 45mg/5ml and Diphenhydramine 8mg/5ml Syrup/Suspension should be stored in a controlled environment, preferably in a cool and dry place away from direct sunlight and moisture. The medication bottles should be tightly sealed to maintain their integrity and prevent contamination. It is crucial to adhere to the recommended storage conditions to ensure the efficacy and safety of the medication. When disposing of the syrup, avoid flushing it down the toilet or pouring it into drainage systems. Instead, consult a pharmacist or healthcare professional for appropriate disposal methods to minimize environmental impact. Keep the medication out of children's reach to prevent accidental consumption.

Following are the quick tips for Acefylline Piperazine 45mg/5ml, Diphenhydramine 8mg/5ml Syrup/Suspension:

• Administer the syrup as directed by the doctor or pharmacist.
• Measure the dose accurately using a calibrated measuring device.
• Ensure the syrup is well-mixed by gently shaking the bottle before each use.
• Take the dose with a full glass of water for better effectiveness.
• Maintain a consistent dosing schedule for optimal results.
• Store the syrup at room temperature, away from direct sunlight and moisture.
• Consult your healthcare provider if you have any concerns or experience side effects.