BROTUX COUGH SYP (S)

Ammonium Chloride Syrup/Suspension primarily works by promoting the removal of excess acid from the body, particularly in the urine. Its mechanism of action involves increasing the excretion of ammonium ions in the urine, which helps to neutralize and eliminate excess acid. When administered, it dissociates into ammonium and chloride ions in the body. The ammonium ions react with the excess acid, forming ammonia and carbon dioxide, which are then eliminated through the lungs and kidneys. This process helps to restore the balance of acid-base levels in the body, making it useful in conditions where there is an accumulation of excess acid, such as in certain respiratory and metabolic disorders.

Ammonium Chloride

Expectorant.

Suspension

The following are the uses of Ammonium Chloride Syrup/Suspension:

• Used for relieving coughs and soothing throat irritation.
• Used for reducing mucus production in the respiratory tract.
• Used for treating symptoms of cold and flu.
• Used as an expectorant, helping to expel mucus and phlegm.
• Used for alleviating chest congestion and making breathing easier.
• Used for its mild sedative effect, providing comfort during respiratory illnesses.
• Used for suppressing dry, irritating coughs.
• Used to provide temporary relief from cough symptoms.

In the case of an overdose of Ammonium Chloride Syrup/Suspension, individuals may experience symptoms such as nausea, vomiting, abdominal pain, and in severe cases, respiratory distress. The severity of symptoms depends on the amount ingested. Prompt medical intervention is necessary to manage these symptoms effectively. Treatment may involve gastric lavage to remove the syrup from the stomach and supportive care to address any respiratory or cardiovascular complications.

In the case of a missed dose of Ammonium Chloride Syrup/Suspension, it is generally recommended to take the missed dose as soon as you remember. However, if it's almost time for your next scheduled dose, skip the missed dose and continue with your regular dosing schedule. Avoid taking a double dose to make up for a missed one, as this may increase the risk of side effects. Consult your healthcare provider if you frequently miss doses or have concerns about managing your medication schedule.

To take Ammonium Chloride Syrup/Suspension, shake the bottle well, then measure the prescribed dose using a measuring cup or oral syringe, and administer it orally, following the dosage instructions provided by your healthcare professional, which may be typically taken twice a day, 12 hours apart, with or without food.

Following are the conditions/situations when Ammonium Chloride Syrup/Suspension should not be used:

• Not suitable for individuals with a known allergy or hypersensitivity to ammonium chloride or any of the excipients in the formulation.
• Contraindicated in patients with severe liver or kidney disease, as it may worsen the condition.
• Should not be used in individuals with severe gastrointestinal disorders or ulcers, as it can irritate the stomach lining.
• Not recommended for patients with respiratory diseases like asthma or chronic obstructive pulmonary disease (COPD), as it may cause respiratory distress.
• Avoid using in individuals with a history of heart disease or hypertension, as it may increase blood pressure.
• Contraindicated during pregnancy, especially in the first trimester, due to potential risks to fetal development.
• Not suitable for breastfeeding mothers, as it may pass into breast milk and harm the infant.
• Should not be used in children under 6 years of age without medical advice, as dosage adjustments may be required.
• Avoid using if you have a condition that causes acid retention in the body, such as renal tubular acidosis.

The side effects of Ammonium Chloride Syrup/Suspension may include:

• Nausea and vomiting
• Diarrhea
• Stomach pain or cramps
• Loss of appetite
• Weakness and fatigue
• Skin rash or hives
• Increased thirst

Following are the precautions and warnings for Ammonium Chloride Syrup/Suspension:

• This medication should not be used in patients with an allergy or hypersensitivity to ammonium chloride or any of the excipients in the formulation.
• It should be used with caution in patients with kidney disease or a history of kidney stones, as it can increase the risk of stone formation.
• Not recommended for long-term use, as it may lead to metabolic acidosis and electrolyte imbalances.
• Patients with a history of gastrointestinal problems should use it with caution, as it can cause irritation and worsen conditions like peptic ulcers.
• Ammonium Chloride Syrup/Suspension should be prescribed with caution in elderly patients due to the potential risk of renal impairment.
• It may cause dizziness or drowsiness, so patients should avoid driving or operating heavy machinery until they know how the medication affects them.
• Always consult a healthcare professional before use, especially if you have any underlying medical conditions or are taking other medications.

Following are the drug interactions for Ammonium Chloride Syrup/Suspension:

• It can interact with medications that affect the kidneys, such as diuretics (e.g., furosemide) and ACE inhibitors (e.g., lisinopril), potentially altering their effectiveness.
• May reduce the absorption of certain medications, including tetracycline antibiotics, thyroid hormones, and some oral contraceptives, leading to decreased efficacy.
• Concomitant use with other medications that increase urinary pH (e.g., sodium bicarbonate) may decrease the effectiveness of Ammonium Chloride.
• It can increase the excretion of potassium, so caution is advised when used with potassium-sparing diuretics or potassium supplements.
• Ammonium Chloride may decrease the absorption of oral antidiabetic medications, requiring close monitoring of blood glucose levels.
• Drugs that slow gastrointestinal motility (e.g., anticholinergics) may delay the absorption and effect of Ammonium Chloride.
• The syrup/suspension may contain sugar, which should be considered when used with medications that affect blood sugar levels.

Following are the food interactions for Ammonium Chloride Syrup/Suspension:

• Avoid excessive consumption of acidic foods like citrus fruits and tomatoes, as they can increase stomach acid production and reduce the effectiveness of the medication.
• Limit your intake of high-sodium foods, such as processed snacks, canned soups, and condiments, as Ammonium Chloride is also a source of sodium.
• Avoid foods and beverages with high sugar content, as the syrup/suspension may already contain sweeteners.
• Grapefruit and grapefruit juice should be consumed in moderation, as they can affect the absorption of various medications.
• Alcohol may irritate the stomach and should be avoided or limited during treatment.
• Dairy products can sometimes increase mucus production, so consider reducing them if you have a respiratory condition.
• Spicy foods might irritate the digestive system and should be consumed sparingly while taking this medication.
• Stay well-hydrated by drinking enough water to maintain fluid balance, especially if you are experiencing increased urination as a side effect.

Ammonium Chloride Syrup/Suspension should be stored in a secure location, preferably in a locked cabinet, at room temperature, ensuring it remains between 68°F and 77°F (20°C and 25°C). Protect it from light and moisture by keeping it in its original container, tightly sealed. Avoid storing it in the bathroom or kitchen, as these areas can be exposed to temperature fluctuations and moisture. Always check the expiration date, and never use the medication if it's past its expiry. When disposing of unused or expired syrup, do not pour it down the drain or flush it; instead, follow local guidelines or consult a pharmacist for safe disposal methods. Keep the medication out of children's reach to prevent accidental consumption, as it can be harmful if ingested inappropriately.

Following are the quick tips for Ammonium Chloride Syrup/Suspension:

• Consult a healthcare professional for proper dosage instructions based on your specific needs.
• Ensure you understand the prescribed dosage and duration of treatment.
• Administer the syrup using the provided measuring device for accurate dosing.
• Store the syrup at room temperature, away from direct sunlight and moisture.
• Do not freeze the suspension as it may affect its effectiveness.
• Avoid taking this medication with other cough and cold medicines to prevent potential interactions.
• Inform your doctor about any existing medical conditions or medications you are taking.