BROXOL DM 120ML SYP

Diphenhydramine and dextromethorphan in syrup/suspension form work through distinct mechanisms of action. Diphenhydramine is a first-generation antihistamine that blocks H1 histamine receptors, providing relief from allergic symptoms and exerting a sedative effect. On the other hand, dextromethorphan acts centrally as a non-opioid cough suppressant by affecting the brain's cough center, reducing the urge to cough. This combination is often used to alleviate symptoms associated with the common cold, allergies, or respiratory tract infections.

Antihistamine, antitussive.

Suspension

The following are the uses of Diphenhydramine, dextromethorphan Syrup/Suspension:

• Used for temporarily relieving symptoms of the common cold, such as sneezing, runny nose, and cough.
• Used for reducing allergic reactions by blocking histamine receptors.
• Used for suppressing coughs, particularly non-productive coughs, to provide relief and promote rest.
• Used for treating upper respiratory tract symptoms associated with allergies or colds.
• Used for alleviating itching and reducing hives caused by various allergic conditions.
• Used for inducing mild sedation and aiding in the relief of occasional sleeplessness.
• Used for providing temporary relief from allergy symptoms like itchy, watery eyes, and nasal congestion.

In the case of an overdose of Diphenhydramine or dextromethorphan syrup/suspension, individuals may experience severe symptoms. These can include confusion, rapid heartbeat, hallucinations, and even seizures. Prompt medical intervention is necessary to manage the overdose effectively. Treatment may involve supportive care, monitoring vital signs, and administering specific medications to counteract the effects of the overdose. It is crucial to seek emergency assistance immediately.

In the case of a missed dose of Diphenhydramine and dextromethorphan Syrup/Suspension, it is important to take the missed dose as soon as you remember. However, if it is almost time for your next dose, skip the missed dose and resume your regular dosing schedule. Do not double the dose to make up for a missed one. If you miss multiple doses, consult your healthcare provider for guidance on how to safely adjust your medication schedule.

To take Diphenhydramine and dextromethorphan syrup/suspension, shake the bottle well, measure the prescribed dose with a measuring device, and administer it orally, following the dosage instructions provided by your healthcare professional, typically taken every 4 to 6 hours as needed, with or without food, but it is best to avoid alcohol during the medication period.

Here are the situations when Diphenhydramine and dextromethorphan Syrup/Suspension should not be used:

• Avoid using this medication if you have a known allergy or hypersensitivity to Diphenhydramine, dextromethorphan, or any of the excipients in the suspension.
• Do not take this medication if you have a history of asthma, chronic obstructive pulmonary disease (COPD), or other respiratory conditions, as it may worsen breathing problems.
• Contraindicated in patients with narrow-angle glaucoma.
• Should not be used in individuals with a history of seizures or those who are currently taking medications that lower the seizure threshold.
• Not recommended for individuals with a history of gastrointestinal obstruction or those with conditions causing difficulty in swallowing.
• Avoid using this medication if you have a history of urinary retention or an enlarged prostate, as it can worsen these conditions.
• Do not use in patients with a history of heart disease, high blood pressure, or cardiovascular disorders.
• Should not be administered to children under 4 years old without medical advice.
• Contraindicated in patients who are taking monoamine oxidase inhibitors (MAOIs) or have taken them within the last 14 days.

The side effects of Diphenhydramine and dextromethorphan Syrup/Suspension may include:

• Drowsiness or sedation
• Dry mouth
• Blurred vision
• Constipation
• Dizziness
• Confusion, especially in older adults
• Increased heart rate
• Difficulty urinating

Following are the precautions and warnings for Diphenhydramine, dextromethorphan Syrup/Suspension:

• Do not consume alcohol while taking this medication, as it may increase the risk of side effects and impair your thinking and reactions.
• This medication can make you dizzy or drowsy. Avoid activities that require mental alertness, such as driving or operating heavy machinery, until you know how this medicine affects you.
• Not recommended for use in children under 12 years old without medical advice.
• Inform your doctor if you have a history of asthma, lung disease, glaucoma, heart disease, high blood pressure, seizures, or an enlarged prostate.
• This medication may cause urination problems, especially in men with enlarged prostates.
• Do not take more than the recommended dose, as it may lead to serious heart problems or death.
• Pregnant and breastfeeding women should consult their doctor before using this medication, as it may have potential risks to the fetus or infant.

Following are the drug interactions for Diphenhydramine, dextromethorphan Syrup/Suspension:

• Alcohol and other central nervous system (CNS) depressants, such as benzodiazepines or opioids, can increase sedation and respiratory depression, leading to potential harm.
• Monoamine oxidase inhibitors (MAOIs) should be avoided as they may prolong and intensify the effects of dextromethorphan, increasing the risk of adverse reactions.
• Dextromethorphan may enhance the effects of serotonergic drugs, including selective serotonin reuptake inhibitors (SSRIs) and serotonin-norepinephrine reuptake inhibitors (SNRIs), potentially leading to serotonin syndrome.
• Diphenhydramine can inhibit the metabolism of certain drugs metabolized by CYP2D6, such as some antidepressants and antipsychotics, resulting in increased side effects.
• Antihistamines and anticholinergic medications may have additive effects, leading to increased drowsiness, dry mouth, and impaired cognitive function.
• Medications that lower the seizure threshold, such as certain antidepressants and antipsychotics, may increase the risk of seizures when combined with dextromethorphan.
• Dextromethorphan may interact with certain antibiotics, such as quinolones and macrolides, potentially increasing the risk of cardiac arrhythmias.

Following are the food interactions for Diphenhydramine, dextromethorphan Syrup/Suspension:

• Grapefruit juice should be avoided as it can interfere with the breakdown of dextromethorphan, potentially increasing its levels in the body and leading to side effects.
• Alcohol consumption should be limited or avoided as it can enhance the sedative effects of Diphenhydramine, causing increased drowsiness and impaired coordination.
• Caffeine-containing beverages like coffee, tea, or energy drinks may counteract the sedative effects of Diphenhydramine, making it less effective for sleep or allergy relief.
• Spicy foods and citrus fruits can potentially irritate the throat and worsen cough symptoms, reducing the effectiveness of dextromethorphan.
• Dairy products like milk can increase mucus production and throat irritation, making coughs more persistent and reducing the efficacy of dextromethorphan.
• Consuming heavy meals before taking this medication may slow its absorption, potentially delaying its effects.
• Certain foods rich in tyramine, such as aged cheeses, cured meats, and fermented foods, should be avoided as they may interact with Diphenhydramine and increase blood pressure.
• Always follow healthcare provider's instructions regarding specific dietary restrictions or recommendations while taking this medication.

Diphenhydramine, dextromethorphan Syrup/Suspension should be stored in a secure location, preferably in a locked medicine cabinet, to prevent unauthorized access. Keep it at room temperature, away from excessive heat or moisture, and avoid freezing. Ensure the bottle is tightly sealed after each use to maintain its integrity. Do not store it in the refrigerator as it may affect the consistency of the suspension. Always check the expiration date, and dispose of the medication responsibly by following local guidelines for pharmaceutical waste disposal. Never pour the syrup down the drain or flush it, as it can cause environmental harm. When discarding, remove any personal information from the packaging to protect your privacy.

Following are the quick tips for Diphenhydramine, dextromethorphan Syrup/Suspension:

• Always follow the dosage instructions provided by your doctor or pharmacist.
• Measure the syrup accurately using the provided measuring cup or spoon.
• Store the medication at room temperature, away from direct sunlight and moisture.
• Avoid driving or operating heavy machinery until you know how the medication affects you.
• Inform your doctor about any other medications you are taking to prevent potential interactions.
• Do not increase or decrease the dosage without consulting your healthcare provider.
• Contact your doctor if you experience persistent or severe side effects.