Brytim (0.2/0.5%) 5ml Eye Drops

Timolol and Brimonidine are both used in eye drops to manage glaucoma and ocular hypertension. Timolol, a beta-blocker, primarily reduces aqueous humor production by inhibiting the β-adrenergic receptors in the ciliary body, thus decreasing intraocular pressure (IOP). It has little to no effect on pupil size or accommodation. Brimonidine, on the other hand, is an α2-adrenergic receptor agonist. It works by dual mechanisms reducing aqueous humor production and increasing uveoscleral outflow, thereby lowering IOP. Brimonidine also has the added effect of decreasing blood flow to the optic nerve head, which may provide additional neuroprotective benefits.

Antiglaucoma agents

Drop

The following are the uses of Timolol, Brimonidine Drop:

• Used for lowering high pressure inside the eye, whether due to glaucoma or other conditions.
• Used for treating open-angle glaucoma or ocular hypertension.
• Used for reducing fluid build-up in the eye to lower intraocular pressure.
• Used for preventing potential damage to the optic nerve and other structures in the eye.
• Used for slowing the progression of glaucoma and preserving vision.
• Used for providing comfort by reducing eye redness and irritation.
• Used for improving overall eye health and reducing the risk of vision loss.

In the case of an overdose of Timolol and Brimonidine eye drops, it is important to act promptly. Symptoms may include increased eye pressure, severe eye redness, and blurred vision. If ingested orally, it can lead to nausea, dizziness, and in severe cases, a slow heartbeat. Seek medical advice immediately, and ensure the eye drops are kept out of reach to prevent accidental ingestion, especially by children.

In the case of a missed dose of Timolol or Brimonidine eye drops, it is important to administer the medication as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue with your regular dosing schedule. Do not double the dose to make up for a missed one, as this may increase the risk of side effects. Simply resume your regular dosing routine and ensure you apply the drops at the appropriate times. If you frequently miss doses, consider setting reminders or using a medication tracking app to help you stay on track.

To administer Timolol and Brimonidine eye drops, gently tilt your head back, pull the lower eyelid down to create a pocket, and hold the dropper close to the eye. Squeeze one drop into the pocket, then gently close your eye and blink to distribute the medication. Wash your hands before and after application, and avoid touching the dropper tip to prevent contamination.

Following are the conditions/situations when Timolol and Brimonidine eye drops should not be used:

• Should not be used if you have a known allergy to either Timolol, Brimonidine, or any other beta-blocker medications.
• Not suitable for individuals with respiratory diseases like asthma, chronic bronchitis, or severe chronic obstructive pulmonary disease (COPD).
• Contraindicated in patients with a history of heart block, heart failure, or severe heart rhythm disorders.
• Should not be used if you have low blood pressure or conditions like Raynaud's syndrome.
• Not recommended for individuals with depression or other mood disorders.
• Avoid using these drops if you have a history of eye injury or recent eye surgery.
• Do not use if you have a condition called narrow-angle glaucoma.
• Should not be used if you have a slow heart rate (bradycardia) or heart disease.
• Contraindicated during pregnancy and breastfeeding.
• Avoid using these drops if you have kidney disease or are undergoing dialysis.

The side effects of Timolol, Brimonidine Drop may include:

• Eye irritation or redness
• Burning or stinging sensation in the eyes
• Dry eyes
• Blurred vision or visual disturbances
• Headache
• Fatigue or drowsiness
• Allergic reactions (e.g., itching, rash)
• Respiratory issues (in rare cases)

Following are the precautions and warnings:

• Timolol and Brimonidine eye drops should not be used by individuals with a known allergy or sensitivity to either of these medications or any of their ingredients.
• These eye drops are for ocular use only and should never be ingested or injected.
• Patients with a history of respiratory diseases like asthma or chronic obstructive pulmonary disease (COPD) should use Timolol with caution as it may exacerbate these conditions.
• Brimonidine can cause drowsiness and dizziness; patients should be cautious when driving or operating heavy machinery until they know how the medication affects them.
• These drops may cause temporary blurred vision, so patients should wait until their vision is clear before performing activities that require clear vision.
• Timolol may mask the symptoms of hypoglycemia (low blood sugar) in diabetic patients, so regular blood sugar monitoring is essential.
• Caution is advised for patients with cardiovascular diseases as Timolol can affect heart rate and blood pressure.
• Pregnant and breastfeeding women should consult their healthcare provider before using these eye drops, as the risks and benefits should be carefully considered.

Following are the drug interactions for Timolol, Brimonidine Drop:

• Drug interaction with other beta-blockers, oral or topical, may result in additive effects and increased risk of hypotension and bradycardia.
• Concomitant use with digoxin can increase the risk of bradycardia and heart block.
• Timolol may reduce the effectiveness of beta-agonist bronchodilators, requiring close monitoring in asthmatic patients.
• It can interact with insulin or oral hypoglycemic agents, masking the symptoms of hypoglycemia.
• The use of tricyclic antidepressants with Timolol may result in increased ocular hypotensive effect and increased risk of adverse cardiovascular events.
• When combined with systemic clonidine, withdrawal of either drug may lead to increased risk of rebound hypertension.
• Brimonidine may interact with monoamine oxidase inhibitors (MAOIs), potentially causing hypertensive crisis.

Following are the food interactions for Timolol, Brimonidine Drop:

• Avoid consuming alcohol while using this medication as it can increase the risk of side effects, especially drowsiness and dizziness.
• Grapefruit and grapefruit juice should be consumed with caution as they may increase the absorption of Timolol, potentially leading to increased side effects.
• Caffeine intake should be monitored as it can affect blood pressure and may interact with the medication's action on the cardiovascular system.
• Foods high in sodium (salt) should be limited as Timolol is used to manage eye pressure, and excess sodium can counteract its effectiveness.
• Brimonidine may cause a dry mouth, so staying well-hydrated and consuming fluids regularly is recommended.
• There is no specific food restriction with Brimonidine, but maintaining a healthy diet is advisable to support overall eye health.
• Always follow the advice of your healthcare provider regarding dietary considerations while using these eye drops.
• Avoid any foods or beverages that you find personally cause discomfort or interact negatively with your medication.

Timolol and Brimonidine Drops should be stored in a cool, dry place, preferably at room temperature, ensuring protection from light and moisture. The original packaging should be retained, keeping the drops in their sealed container to maintain sterility. Avoid extreme temperatures, such as those near heating devices or inside hot cars, as they can degrade the medication. Always check the expiration date, and dispose of any unused or expired drops responsibly; do not flush or pour them down the drain. Contact your pharmacist or local waste management authority for guidance on safe disposal practices. Keep the medication securely stored, out of the reach of children, to prevent accidental exposure or ingestion.

Following are the quick tips for Timolol, Brimonidine Drop:

• Wash your hands before using the drops to maintain hygiene.
• Tilt your head back, look up, and gently pull down your lower eyelid to create a pocket.
• Hold the dropper close to your eye, without touching it, and squeeze the prescribed number of drops into the pocket.
• Close your eyes gently and tip your head down for a few minutes to allow the medication to absorb.
• Avoid touching the dropper tip to your eye or any surface to prevent contamination.
• If using other eye medications, wait at least 5 minutes before applying the next one.
• Store the drops at room temperature, away from direct sunlight and moisture.