Bufac 5g Cream

Hydrocortisone Sodium Succinate 500mg Cream primarily exerts its therapeutic effects through its active ingredient, hydrocortisone, which is a potent synthetic corticosteroid. When applied topically, hydrocortisone binds to and activates glucocorticoid receptors in the skin cells. This activation leads to the suppression of various inflammatory processes by inhibiting the production and release of pro-inflammatory mediators such as prostaglandins, leukotrienes, and certain cytokines. It also stabilizes the cell membrane, reducing the migration of inflammatory cells to the site of inflammation. As a result, hydrocortisone sodium succinate cream effectively reduces redness, itching, and swelling associated with various skin conditions by modulating the immune response and mitigating the inflammatory cascade.

Betamethasone valerate, Nystatin, Neomycin

Corticosteroid

cream

The following are the uses of Hydrocortisone Sodium Succinate 500mg Cream:

• Used for treating severe allergic reactions, such as anaphylaxis.
• Used for managing acute asthma attacks that require intensive care.
• Used in cases of adrenal insufficiency, providing necessary corticosteroid replacement.
• Used to reduce inflammation and manage symptoms in certain autoimmune disorders.
• Used for rapid improvement in various inflammatory skin conditions.
• Used to prevent and treat nausea and vomiting caused by chemotherapy.
• Used to suppress the immune system to prevent organ rejection after transplants.

In the case of an overdose of Hydrocortisone Sodium Succinate 500mg Cream, it is important to remain calm and take swift action. First, contact a healthcare professional or a poison control center for guidance. They will provide specific instructions based on the severity of the overdose. If the cream has been ingested, do not induce vomiting unless advised by a medical professional. Instead, provide them with a sample of the cream and its packaging for accurate identification and treatment.

In the case of a missed dose of Hydrocortisone Sodium Succinate 500mg Cream, it is important to apply the medication as soon as you remember. However, if it is almost time for your next dose, skip the missed dose and continue with your regular dosing schedule. Do not double the dose to make up for a missed one. If you miss multiple doses, contact your healthcare provider for guidance on how to adjust your treatment plan accordingly. It is generally recommended to follow the prescribed application frequency for optimal results.

To administer Hydrocortisone Sodium Succinate 500mg Cream, gently apply a thin layer to the affected area of the skin, typically twice a day or as directed by your healthcare provider, ensuring not to exceed the prescribed dosage.

Following are the conditions/situations when Hydrocortisone Sodium Succinate 500mg Cream should not be used:

• Do not use if you have a known allergy to hydrocortisone or any other ingredients in the cream.
• Avoid using it on infected skin areas or open wounds.
• Not suitable for individuals with certain skin conditions like rosacea, acne, or perioral dermatitis.
• Do not use on skin affected by tuberculosis, shingles, or chickenpox.
• Avoid using around the eyes, mouth, or other sensitive areas unless directed by a healthcare professional.
• Not recommended for long-term use without medical supervision.
• Do not use if the cream shows signs of discoloration or changes in consistency.

The side effects of Hydrocortisone Sodium Succinate 500mg Cream may include:

• Skin thinning, dryness, or irritation at the application site
• Skin redness or discoloration
• Acne or pimples
• Excessive hair growth
• Stretch marks
• Slow wound healing
• Allergic reactions (such as rash, itching, or swelling)
• Increased blood pressure

Following are the precautions and warnings for Hydrocortisone Sodium Succinate 500mg Cream:

• Do not use if you are allergic to hydrocortisone or any other ingredients in the cream.
• Avoid contact with eyes, nose, and mouth. In case of accidental contact, rinse thoroughly with water.
• This cream is for external use only and should not be ingested or used on open wounds or infections.
• Prolonged use of high-potency corticosteroids like this can lead to skin thinning, stretch marks, or skin color changes; monitor for these effects.
• Do not use on large areas of the body or for extended periods without medical supervision.
• Avoid using occlusive dressings over the treated area, as this may increase the risk of local side effects.
• If symptoms persist or worsen after a few days of treatment, consult a healthcare professional.

Following are the drug interactions for Hydrocortisone Sodium Succinate 500mg Cream:

• Avoid combining with other topical corticosteroids, as this may increase the risk of skin atrophy and other local side effects.
• The effect of Hydrocortisone may be reduced by strong CYP3A4 inducers like rifampicin, leading to decreased efficacy.
• Caution with oral anticoagulants; Hydrocortisone can increase the risk of bleeding, requiring close monitoring of coagulation parameters.
• Concomitant use with antidiabetic medications may require adjustment of the diabetes treatment due to its effects on glucose metabolism.
• Potassium-depleting diuretics may increase the risk of hypokalemia when used with Hydrocortisone, necessitating potassium monitoring.
• Use with non-steroidal anti-inflammatory drugs (NSAIDs) may increase the likelihood of gastrointestinal side effects and ulceration.
• Live vaccines should be avoided during treatment with Hydrocortisone due to potential immune suppression and reduced vaccine efficacy.
• Anticonvulsant medications may have their blood levels affected by Hydrocortisone, requiring monitoring and potential dose adjustments.

Following are the food interactions for Hydrocortisone Sodium Succinate 500mg Cream:

• Avoid excessive salt or high-sodium foods, as they can increase fluid retention and elevate blood pressure, especially if used for prolonged periods.
• Limit or avoid foods containing potassium like bananas, oranges, and tomatoes, as Hydrocortisone can cause potassium loss.
• Monitor calcium intake, as long-term use may lead to calcium depletion and weaken bones.
• Avoid high-sugar foods, as Hydrocortisone can increase blood sugar levels, especially in diabetics.
• Limit alcohol consumption as it can increase the risk of gastrointestinal issues and may affect the absorption of the medication.
• There is no direct interaction with specific foods, but a balanced diet is essential to manage overall health while using this medication.
• Always consult your healthcare provider for personalized dietary advice based on your medical condition.

Hydrocortisone Sodium Succinate 500mg Cream should be stored and disposed of with care to ensure safety and environmental responsibility. Store the cream in a cool, dry place, away from direct sunlight and heat sources, as temperature fluctuations can impact its effectiveness. Keep the cream in its original packaging, tightly sealed, to maintain its integrity and prevent contamination. Always check the expiration date, and never use the cream beyond its expiry. When disposing of the cream, avoid flushing it down the toilet or pouring it into drains. Instead, consult your pharmacist or healthcare provider for appropriate disposal methods to minimize environmental impact. Keep the cream out of children's reach to prevent accidental exposure or ingestion. Proper storage and disposal practices are crucial for maintaining the quality and safety of the medication.

Following are the quick tips for Hydrocortisone Sodium Succinate 500mg Cream:

• Consult a doctor for personalized advice before using the cream.
• Apply a thin layer to the affected area as directed by your physician.
• Wash your hands before and after application for hygiene.
• Avoid contact with eyes, nose, and mouth during application.
• Do not apply to open wounds, infections, or severely damaged skin.
• Store the cream at room temperature, away from direct sunlight and moisture.
• Discontinue use and seek medical attention if irritation or allergy occurs.