Busid (2%) 15g Cream

Hydrocortisone cream primarily exerts its therapeutic effects through its active ingredient, hydrocortisone, which is a synthetic corticosteroid. Upon application to the skin, hydrocortisone binds to intracellular corticosteroid receptors in the cytoplasm of target cells. This binding triggers a series of cellular events, including the modulation of gene expression and the suppression of inflammatory mediators. Specifically, hydrocortisone inhibits the production and release of pro-inflammatory molecules such as prostaglandins, leukotrienes, and cytokines, thereby reducing inflammation, itching, and redness associated with various skin conditions. It also stabilizes cell membranes, preventing the release of additional inflammatory substances. The overall mechanism of action of hydrocortisone cream involves its potent anti-inflammatory and immunosuppressive properties, which help alleviate symptoms and promote healing in various dermatological disorders.

Hydrocortisone

Corticosteroid cream

Cream

The following are the uses of Hydrocortisone Cream:

• Used for reducing inflammation and relieving itching caused by various skin conditions such as eczema, dermatitis, and allergic reactions.
• Used for treating mild to moderate inflammatory skin issues, offering relief from redness, swelling, and discomfort.
• Used as a topical medication to manage skin inflammation after insect bites, minor burns, or exposure to irritants.
• Used in managing skin conditions like psoriasis, helping to reduce scaling, itching, and inflammation.
• Used to provide temporary relief from minor skin irritations, rashes, and itching due to cosmetics or jewelry.
• Used for soothing and healing skin affected by mild acne, reducing redness and inflammation.
• Used post-surgery or after certain medical procedures to minimize skin irritation and promote healing.
• Used as a short-term treatment for localized skin issues, providing relief from symptoms until the underlying issue is addressed.

In the case of an overdose of Hydrocortisone Cream, it is important to remain calm and take appropriate action. While it is generally considered safe, excessive use can lead to increased absorption, potentially causing systemic effects. If you suspect an overdose, immediately wash the affected area with warm water to remove any excess cream. Contact a healthcare professional or a poison control center for further guidance, as they can provide specific instructions based on the severity of the situation.

In the case of a missed dose of Hydrocortisone Cream, it is important to apply the medication as soon as you remember. However, if it is almost time for your next dose, skip the missed dose and continue with your regular schedule. Do not apply extra cream to make up for the missed application. If you miss multiple doses, consult your healthcare provider for guidance on how to adjust your dosage and get back on track with your treatment plan. It is crucial to maintain a consistent application schedule for the cream to be most effective.

To use Hydrocortisone Cream, gently clean and dry the affected skin area, then apply a thin layer of the cream, rubbing it in gently, usually 2-3 times a day or as directed by your doctor, ensuring you follow the prescribed dosage and duration of treatment.

Following are the conditions or circumstances when Hydrocortisone Cream should not be applied:

• Avoid using it if you have a known allergy or sensitivity to Hydrocortisone or any other steroid medications.
• Do not use on infected skin areas, unless directed by a healthcare professional.
• Not suitable for long-term use without medical supervision, as prolonged use can lead to skin thinning.
• Avoid applying on skin conditions like rosacea, acne, or perioral dermatitis, as it can worsen these conditions.
• Do not use on skin that is broken, severely damaged, or has open wounds.
• Not recommended for infants or young children without medical advice, as their skin is more sensitive.
• Avoid using it on the face, unless specifically prescribed by a doctor.
• Do not use Hydrocortisone Cream on skin areas affected by chickenpox, shingles, or other viral infections.
• Discontinue use and seek medical advice if you experience burning, stinging, or irritation after application.

The side effects of Hydrocortisone Cream may include:

• Skin irritation or itching at the application site
• Burning or stinging sensation
• Dryness or peeling of the skin
• Redness or inflammation
• Thinning of the skin
• Acne or pimples
• Allergic reactions (such as rash, swelling, or difficulty breathing)
• Prolonged use may lead to stretch marks or skin discoloration.

Following are the precautions and warnings for Hydrocortisone Cream:

• Do not use on the face, underarms, or groin unless directed by a healthcare professional, as these areas are more sensitive.
• Avoid contact with eyes and mucous membranes. If accidental contact occurs, rinse thoroughly with water.
• Do not use for an extended period without medical supervision, especially on large areas of skin or on broken skin.
• Do not use under occlusive dressings or bandages unless instructed by a doctor, as this may increase the absorption of the medication.
• Discontinue use and seek medical advice if the condition worsens, or if symptoms such as itching, irritation, or redness persist or worsen.
• Keep out of reach of children. Store at room temperature, away from heat and direct sunlight.
• Consult a doctor if you are pregnant, planning to become pregnant, or breastfeeding before using this medication.

Following are the drug interactions for Hydrocortisone Cream:

• Topical antibiotics like neomycin or bacitracin may increase the risk of skin irritation or mask signs of infection when used with Hydrocortisone Cream.
• Applying other topical corticosteroids simultaneously can lead to increased skin thinning and other local side effects.
• Hydrocortisone may interact with systemic corticosteroids, potentially increasing the risk of adrenal suppression.
• It can reduce the effectiveness of live vaccines, so vaccinations should be planned carefully.
• Antifungal creams containing miconazole or clotrimazole might enhance the absorption of hydrocortisone, leading to increased systemic effects.
• Caution with drugs that affect CYP3A4 enzyme, as they may alter hydrocortisone metabolism.
• The use of Hydrocortisone Cream with other skin products containing acids (e.g., salicylic acid, glycolic acid) can cause skin dryness and irritation.

Following are the food interactions for Hydrocortisone Cream:

• Avoid excessive alcohol consumption while using Hydrocortisone as it can increase the risk of gastrointestinal issues and may reduce the cream's effectiveness.
• Grapefruit and grapefruit juice should be consumed with caution as they can potentially affect the metabolism of Hydrocortisone, leading to increased drug levels in the body.
• Caffeine intake should be monitored as it may interact with Hydrocortisone, causing increased heart rate and blood pressure.
• Avoid high-sodium foods, as Hydrocortisone can increase sodium retention, leading to fluid retention and elevated blood pressure.
• Limit spicy foods, as they may irritate the skin and exacerbate skin conditions when used with Hydrocortisone Cream.
• Be cautious with vitamin A-rich foods like liver, as excessive intake can enhance the effects of Hydrocortisone and increase the risk of side effects.
• Always stay well-hydrated to support skin health and the effectiveness of the cream.
• Generally, Hydrocortisone Cream has minimal food interactions, but individual responses may vary, so consult your healthcare provider for personalized advice.

Hydrocortisone Cream should be stored in a cool and dry place, preferably at room temperature, ensuring it is kept away from direct sunlight, heat, and moisture. The original container should be tightly sealed to maintain its integrity and prevent contamination. It is crucial not to store the cream in bathrooms or near heat sources as temperature fluctuations can impact its effectiveness. Always check the expiration date, and if the cream has passed its expiry, it must be disposed of responsibly. Avoid flushing or pouring it down the drain; instead, consult a pharmacist or healthcare professional for appropriate disposal methods. Keep the cream out of children's reach to prevent accidental exposure or ingestion.

Following are the quick tips for Hydrocortisone Cream:

• Clean and dry the affected area before applying the cream for better absorption.
• Apply a thin layer of cream to the skin, gently rubbing it in until it disappears.
• Wash your hands thoroughly after application to avoid spreading the medication.
• Avoid applying the cream to broken or infected skin to prevent further irritation.
• Do not cover the treated area with bandages or tight clothing to allow the skin to breathe.
• Store the cream at room temperature, away from direct sunlight and moisture.
• Discontinue use and consult a doctor if symptoms worsen or persist after a few days.