Caduet (5/10mg) 7 Tablets

Amlodipine 5mg and Atorvastatin 10mg work synergistically to manage cardiovascular conditions. Amlodipine, a calcium channel blocker, selectively inhibits calcium ion influx into cardiac and vascular smooth muscle cells, leading to vasodilation and reduced peripheral vascular resistance. This action lowers blood pressure and decreases the workload on the heart. Atorvastatin, a potent HMG-CoA reductase inhibitor, reduces cholesterol synthesis in the liver by competitively inhibiting the enzyme responsible for converting HMG-CoA to mevalonate, a precursor of cholesterol. This inhibition results in decreased LDL cholesterol production and enhanced clearance of LDL particles from the bloodstream, thereby lowering total cholesterol and LDL cholesterol levels.

Amlodipine 5mg, Atorvastatin 10mg

Calcium channel blocker, HMG-CoA reductase inhibitor.

Tablet

The following are the uses of Amlodipine 5mg, Atorvastatin 10mg Tablet:

• Used for lowering high blood pressure and preventing chest pain (angina).
• Used to manage and prevent cardiovascular diseases by reducing high cholesterol levels.
• Used to relax and widen blood vessels, improving blood flow.
• Used for long-term management of high blood pressure and high cholesterol.
• Used to reduce the risk of heart attacks and strokes in patients with cardiovascular risks.
• Used to treat conditions such as peripheral vascular disease and coronary artery disease.
• Used to prevent further complications in patients with a history of heart-related issues.

In the case of an overdose of Amlodipine 5mg and Atorvastatin 10mg tablets, individuals may experience symptoms such as low blood pressure, dizziness, and lightheadedness. An overdose of Amlodipine can lead to excessive peripheral vasodilation, while an overdose of Atorvastatin may cause muscle pain and liver damage. It is important to seek medical advice if an overdose is suspected, as treatment may involve supportive measures and monitoring of vital signs. Prompt medical intervention can help manage the potential adverse effects and ensure patient safety.

In the case of a missed dose of Amlodipine 5mg, take it as soon as you remember, but if it's almost time for your next dose, skip the missed dose and continue with your regular schedule. For Atorvastatin 10mg, if you miss a dose, take it as soon as you remember, but do not take a double dose to make up for the missed one. If it's almost time for your next dose, skip the missed dose and continue with your regular dosing schedule. It's important to try to take your medication at the same time each day to maintain consistent levels in your body.

To take Amlodipine 5mg and Atorvastatin 10mg tablets, swallow one tablet of each medication as a single dose, preferably at the same time daily, as directed by your healthcare provider.

Following are the conditions/situations when Amlodipine 5mg and Atorvastatin 10mg Tablet should not be taken:

• Should not be used in patients with a known allergy to Amlodipine, Atorvastatin, or any other similar medications.
• Not recommended for individuals with severe liver disease.
• Contraindicated in patients with uncontrolled or severe heart failure.
• Avoid using this medication if you have a history of muscle pain or weakness, especially if caused by previous statin use.
• Should not be used in patients with a history of unexplained elevated liver enzymes.
• Not suitable for individuals with hypotension (low blood pressure).
• Avoid using this medication if you have a history of liver disease or heavy alcohol consumption.

The side effects of Amlodipine 5mg and Atorvastatin 10mg Tablet may include:

• Dizziness or lightheadedness
• Fatigue or weakness
• Headache
• Nausea and vomiting
• Constipation or diarrhea
• Muscle pain and weakness
• Swelling of ankles and feet
• Skin rash or itching

Following are the precautions and warnings for Amlodipine 5mg, Atorvastatin 10mg Tablet:

• Patients with known allergies to amlodipine, atorvastatin, or related medications should not take this tablet.
• This medication may affect liver function, so regular monitoring is necessary, especially for those with pre-existing liver conditions.
• Patients with kidney problems should exercise caution and inform their doctor, as dosage adjustments might be needed.
• It may cause dizziness; patients should avoid activities requiring alertness until they know how the medication affects them.
• Do not consume grapefruit or grapefruit juice while on this medication, as it can increase the drug's effects.
• Inform your doctor if you have a history of muscle pain or weakness before taking this medication.
• Pregnant or breastfeeding women should consult their doctor, as the medication may have potential risks for the fetus or infant.
• Always follow the prescribed dosage, and do not stop taking the medication without consulting your healthcare provider.

Following are the drug interactions for Amlodipine 5mg and Atorvastatin 10mg Tablet:

• Grapefruit juice can increase the blood levels of amlodipine, leading to increased side effects. Avoid consumption of grapefruit products.
• Amlodipine may enhance the blood pressure-lowering effect of antihypertensive medications, requiring close monitoring.
• Atorvastatin can increase the risk of muscle-related side effects when taken with certain antibiotics, antifungals, and HIV protease inhibitors.
• Combining Atorvastatin with other cholesterol-lowering medications like fibrates or niacin may increase the risk of liver problems and muscle damage.
• The blood pressure-lowering effect of Amlodipine may be reduced by NSAIDs (e.g., ibuprofen).
• Antacids may decrease the absorption of Atorvastatin, so take Atorvastatin at least 2 hours before or 4 hours after taking antacids.
• Amlodipine may increase the blood levels of certain beta-blockers, potentially enhancing their effects and side effects.

Following are the food interactions for Amlodipine 5mg and Atorvastatin 10mg Tablet:

• Grapefruit and grapefruit juice should be avoided as they can increase the concentration of Amlodipine in the blood, potentially leading to an increased risk of side effects.
• Avoid excessive alcohol consumption as it may increase the blood pressure-lowering effect of Amlodipine and enhance the risk of side effects like dizziness and lightheadedness.
• Atorvastatin may interact with high-fat diets, as it is primarily used to manage high cholesterol levels. Follow a balanced diet as recommended by your doctor.
• Avoid eating large amounts of licorice, as it may decrease the effectiveness of Amlodipine.
• No significant food interactions are known for Atorvastatin, but it's best to maintain a healthy diet to support overall cardiovascular health.
• Avoid excessive consumption of vitamin K-rich foods (like leafy greens) as they can interfere with the blood-thinning effects of Atorvastatin.
• Always follow the dietary recommendations provided by your healthcare provider to ensure optimal medication effectiveness.

Amlodipine 5mg and Atorvastatin 10mg tablets should be stored in a cool, dry place, preferably at room temperature, ensuring protection from light and moisture. Keep the medication in its original container, tightly sealed, to maintain its integrity and prevent contamination. It is crucial not to expose the tablets to high temperatures or humidity, so avoid storage in bathrooms or near heat-emitting appliances. Regularly check the expiration date, and dispose of any unused or expired tablets responsibly. Avoid flushing or pouring them down the drain; consult a pharmacist or healthcare professional for appropriate disposal methods. Additionally, keep the medication securely stored, out of children's reach, to prevent accidental consumption.

Following are the quick tips for Amlodipine 5mg and Atorvastatin 10mg Tablet:

• Take the medication as directed by your doctor for best results.
• Swallow the tablet whole; do not crush or chew it.
• Maintain a consistent schedule for taking your medication.
• Avoid grapefruit and grapefruit juice while on this medication.
• Inform your doctor about all medications and supplements you take.
• Do not stop taking the medication without consulting your healthcare provider.
• Store the medication in a cool, dry place, away from direct sunlight.
• Regularly monitor your blood pressure and cholesterol levels as advised by your doctor.