CAFERGOT TAB

Ergotamine tartrate with caffeine tablets work primarily by constricting blood vessels in the brain, thereby reducing the severity and frequency of migraine attacks. Ergotamine acts as a vasoconstrictor, stimulating specific serotonin receptors in the blood vessels, leading to their narrowing. This vasoconstriction helps to reduce the dilatation of cerebral blood vessels, which is believed to contribute to migraine headaches. Caffeine, when combined with ergotamine, enhances its effectiveness by increasing its absorption and prolonging its action. Caffeine also has vasoconstrictive properties, further contributing to the reduction of blood vessel diameter and alleviating the symptoms associated with migraines.

Antimigraine

Tablet

The following are the uses of Ergotamine tartarate with caffeine Tablet:

• Used for the treatment of migraine headaches, providing relief from pain, nausea, and light sensitivity.
• Used to stop a migraine attack in its tracks, helping to reduce the severity and duration.
• Used as a preventive measure for those who experience frequent migraines, reducing the frequency and intensity of episodes.
• Used to constrict blood vessels in the brain, reducing inflammation and providing relief from migraine symptoms.
• Used to enhance the pain-relieving effects of ergotamine, making the treatment more effective.
• Used to improve alertness and reduce migraine-related fatigue, allowing individuals to continue their daily activities.
• Used for its ability to suppress the release of certain neurotransmitters, which play a role in triggering migraine attacks.

In the case of an overdose of Ergotamine tartrate with caffeine tablets, individuals may experience severe side effects such as nausea, vomiting, diarrhea, abdominal pain, and in extreme cases, seizures or cardiovascular issues. Prompt medical intervention is necessary to manage the symptoms and prevent potential complications. Treatment may involve supportive care, gastric lavage, or the administration of specific antidotes to counteract the effects of the overdose. It is crucial to seek medical advice and ensure the patient receives appropriate monitoring and treatment.

In the case of a missed dose of Ergotamine tartrate with caffeine tablets, it is important to take the dose as soon as you remember. However, if it is almost time for your next scheduled dose, skip the missed dose and continue with your regular dosing schedule. Do not take a double dose to make up for the missed one. If you miss multiple doses, consult your healthcare professional for advice on how to safely resume your medication regimen without causing any adverse effects.

To take Ergotamine tartrate with caffeine tablets, place the tablet under your tongue (sublingual) and allow it to dissolve completely, preferably on an empty stomach, following the dosage instructions provided by your healthcare professional.

Here are the situations or conditions when Ergotamine tartrate with caffeine tablets should not be used:

• Avoid using if you have a known allergy to ergotamine, caffeine, or any other related compounds.
• Do not take this medication if you have severe cardiovascular diseases, including uncontrolled high blood pressure, coronary artery disease, or peripheral vascular disease.
• Contraindicated in individuals with severe liver or kidney impairment.
• Should not be used by patients with severe infections or sepsis.
• Avoid using this medication if you have recently had surgery, especially vascular surgery or procedures.
• Not recommended for individuals with severe migraines or headaches that are different from your usual pattern.
• Do not take this medication if you have peripheral vascular disease, including Raynaud's syndrome or ischemia.
• Contraindicated during pregnancy or breastfeeding.
• Should not be used by individuals with a history of stroke, transient ischemic attacks (TIAs), or severe migraines with aura.
• Avoid using this medication if you have uncontrolled diabetes or blood circulation disorders.

The side effects of Ergotamine tartrate with caffeine tablets may include:

• Nausea and vomiting
• Abdominal pain and cramps
• Dizziness and lightheadedness
• Weakness and fatigue
• Numbness or tingling sensation in the extremities
• Increased heart rate or palpitations
• Muscle pain or weakness
• Visual disturbances, such as blurred vision or temporary vision loss.

Following are the precautions and warnings for Ergotamine tartrate with caffeine tablets:

• This medication should not be used by individuals with a known allergy to ergotamine, caffeine, or any other ingredients in the tablet.
• Patients with cardiovascular diseases, hypertension, or peripheral vascular disorders should use with caution, as it may worsen these conditions.
• Not recommended for use in pregnant or breastfeeding women due to potential risks to the fetus and infant.
• Patients with liver or kidney impairment may require dosage adjustments, and regular monitoring is advised.
• Elderly individuals may be more susceptible to side effects, and close supervision is necessary.
• Avoid sudden changes in posture to prevent dizziness and orthostatic hypotension.
• Do not use this medication if you have uncontrolled high blood pressure, severe infection, or coronary artery disease.

Following are the drug interactions for Ergotamine Tartrate with Caffeine Tablet:

• Macrolide antibiotics (e.g., erythromycin) can increase the concentration of ergotamine, leading to increased side effects and toxicity.
• Combining with antifungal medications like ketoconazole can also increase ergotamine levels in the body, requiring careful monitoring.
• It may interact with protease inhibitors, a type of HIV medication, potentially increasing ergotamine levels and the risk of adverse effects.
• Use with calcium channel blockers, such as verapamil, can affect the metabolism of ergotamine, leading to increased drug exposure.
• Concomitant use with certain antidepressants (e.g., SSRIs, SNRIs) may enhance the risk of serotonin syndrome, characterized by increased serotonin activity in the body.
• Ergotamine can reduce the effectiveness of oral contraceptives, requiring alternative birth control methods during treatment.
• Caution is advised when taking with drugs that affect the liver, as this may alter the metabolism and elimination of ergotamine.

Following are the food interactions for Ergotamine tartrate with caffeine tablets:

• Avoid consuming foods and beverages containing caffeine, such as coffee, tea, energy drinks, and chocolate. Caffeine can increase the effects of this medication, leading to potential side effects.
• Grapefruit and grapefruit juice should be consumed with caution. These can affect the metabolism of the medication, potentially increasing the levels of Ergotamine in the blood and raising the risk of adverse effects.
• Alcohol consumption should be minimized or avoided. Alcohol may increase the risk of side effects, particularly related to the central nervous system, such as dizziness, headaches, and nausea.
• Dairy products, especially high-fat dairy, may reduce the absorption of Ergotamine. It is advisable to separate the medication and dairy intake by a few hours.
• Fatty meals can also affect the absorption of Ergotamine. It is best to take the medication on an empty stomach or at least one hour before or two hours after a meal.
• Smoking tobacco can reduce the effectiveness of Ergotamine. It is recommended to avoid smoking to ensure the medication works optimally.
• Certain protein-rich foods like meat and eggs may also interact with Ergotamine absorption. Consuming these foods simultaneously as the medication may reduce its effectiveness.
• Always ensure you are well-hydrated when taking this medication, as dehydration can increase the risk of side effects.

Ergotamine tartrate with caffeine tablets should be stored in a secure and controlled environment, preferably in a cool, dry place, away from direct sunlight, moisture, and extreme temperatures. It is crucial to keep the medication in its original packaging, ensuring the container is tightly sealed to maintain its integrity and prevent exposure to environmental factors. When disposing of unused or expired tablets, it is recommended to follow local pharmaceutical waste guidelines or consult a healthcare professional for appropriate disposal methods. Avoid flushing the medication down the toilet or discarding it in regular trash, as this can pose environmental risks. Keep the medication safely locked away from children and pets to prevent accidental ingestion. Always handle and store pharmaceutical products with care to maintain their efficacy and safety.

Following are the quick tips for Ergotamine tartarate with caffeine tablets:

• Consult your doctor before use, especially if you have pre-existing medical conditions.
• Take the tablets as directed by your healthcare provider, typically at the first sign of a migraine.
• Do not exceed the recommended dosage, as it may lead to increased side effects.
• Avoid operating heavy machinery or driving until you know how the medication affects you.
• Store the tablets in a cool, dry place, away from direct sunlight.
• Inform your doctor about all medications you are taking to prevent potential drug interactions.
• Contact your doctor if your migraines worsen or occur more frequently despite treatment.