Calcipot (50mcg/g) 30g Cream

Calcipotriol, the active ingredient in Calcipotriol Cream, is a synthetic derivative of vitamin D3. Its mechanism of action primarily involves regulating gene expression in the skin cells, particularly in keratinocytes. Calcipotriol binds to the vitamin D receptor (VDR) within the cell, forming a complex that then interacts with specific DNA sequences known as vitamin D response elements (VDREs). This binding process activates or represses the transcription of genes involved in keratinocyte proliferation and differentiation. As a result, Calcipotriol helps normalize the rate of skin cell growth and reduces the inflammation associated with conditions like psoriasis by slowing down the rapid growth of skin cells and promoting their maturation.

Calcipotriol

vitamin D analogue.

Cream

The following are the uses of Calcipotriol Cream:

• Used for treating psoriasis, a skin condition characterized by red, itchy, scaly patches.
• Used for slowing down the rapid growth of skin cells, which is a key feature of psoriasis.
• Used for reducing inflammation and irritation in affected areas, providing relief from itching and discomfort.
• Used for promoting the removal of built-up skin cells, helping to smooth the skin's texture.
• Used for improving the appearance of psoriatic plaques, leading to clearer skin.
• Used for long-term management of psoriasis, often in combination with other therapies.
• Used for localized areas of psoriasis, applied directly to the affected skin.
• Used for maintaining skin health and preventing flare-ups when used consistently as prescribed.

In the case of an overdose of Calcipotriol Cream, it is important to remain calm and take appropriate action. The severity of symptoms may vary depending on the amount applied. If a large amount is accidentally ingested, it can lead to nausea, vomiting, and an upset stomach. In such instances, seek medical advice promptly. For any concerns or questions regarding an overdose, contact a healthcare professional or a poison control center for guidance and further instructions.

In the case of a missed dose of Calcipotriol Cream, it is important to apply the medication as soon as you remember. If it is almost time for your next scheduled application, skip the missed dose and continue with your regular dosing schedule. Do not apply extra cream to make up for the missed dose, as this may increase the risk of side effects. If you miss multiple doses, contact your healthcare provider for guidance on how to get back on track with your treatment plan. It is best to maintain a consistent routine to ensure the medication's effectiveness.

To apply Calcipotriol Cream, clean and dry the affected skin area, then gently massage a thin layer of the cream onto the skin, usually once or twice a day, or as directed by your healthcare provider, ensuring you follow the prescribed frequency and duration of treatment.

Following are the conditions when Calcipotriol Cream should not be used:

• Avoid using if you are allergic to Calcipotriol or any vitamin D analogs.
• Do not use on broken or infected skin.
• Not suitable for individuals with kidney disease or impaired kidney function.
• Do not apply on the face or around the eyes, mouth, or nose.
• Contraindicated for individuals who are pregnant or breastfeeding.
• Should not be used on children under 12 years of age.
• Avoid using on skin conditions like eczema, rosacea, or acne.
• Do not use if you are taking other medications containing vitamin D or calcium.
• Not recommended for individuals with a history of sensitivity to any of the cream's components.
• Avoid prolonged use on large areas of the body.

The side effects of Calcipotriol Cream may include:

• Skin irritation at the application site
• Redness or erythema
• Itching or pruritus
• Dry skin
• Burning sensation
• Skin peeling or scaling
• Skin rash or dermatitis
• Increased sensitivity to sunlight

Following are the precautions and warnings for Calcipotriol Cream:

• Avoid contact with eyes, mouth, and other mucous membranes. If accidental contact occurs, rinse thoroughly with water.
• This cream is for external use only and should not be ingested or applied to open wounds or severely inflamed skin.
• It should not be used on the face unless prescribed by a doctor, as it may cause severe irritation.
• Calcipotriol Cream can make your skin more sensitive to sunlight. Avoid excessive sun exposure and use sunscreen when outdoors.
• Do not use this medication on large areas of the body, as it may lead to increased absorption and potential side effects.
• Not recommended for children under 12 years old without medical advice.
• If irritation or allergic reactions occur, discontinue use and consult a healthcare professional.
• Keep out of reach of children and pets.

Following are the drug interactions for Calcipotriol Cream:

• Calcipotriol may increase the absorption of other topical medications, leading to potential adverse effects. Avoid using other creams or ointments at the same treatment site.
• The cream may enhance the absorption of other drugs, including corticosteroids, through the skin, potentially increasing their systemic effects.
• It can interact with systemic retinoids, such as acitretin, resulting in increased risk of local skin irritation and toxicity.
• Topical steroids used with Calcipotriol can mask the symptoms of infection, making it difficult to detect and treat.
• Using Calcipotriol with other vitamin D analogs may lead to hypercalcemia, causing symptoms like nausea, vomiting, and muscle weakness.
• The cream may increase the sensitivity of the skin to sunlight, and concurrent use of photosensitizing drugs can further exacerbate this effect.
• Avoid using other medications with a similar mechanism of action, as it may lead to additive side effects and increased risk of adverse reactions.

Following are the food interactions to consider with Calcipotriol Cream:

• Avoid excessive sunlight exposure, including tanning beds and sunlamps, as this medication may increase sensitivity to UV rays, leading to sunburns.
• Limit or avoid alcohol consumption, as it can cause dehydration and potentially exacerbate skin dryness or irritation.
• Vitamin D-rich foods like fatty fish, egg yolks, and fortified dairy products should be consumed in moderation, as excessive Vitamin D intake may influence the effectiveness of Calcipotriol.
• Calcium-rich foods such as dairy products, dark leafy greens, and fortified foods should be balanced in the diet, as they can interact with the medication's calcium metabolism effects.
• Avoid high-potassium foods like bananas, oranges, and spinach in excess, as Calcipotriol can affect potassium levels in the body.
• Limit caffeine intake from coffee, tea, and energy drinks, as it may dehydrate the skin and potentially enhance skin irritation.
• Stay well-hydrated by drinking adequate water, as this helps maintain skin moisture and reduces the risk of dryness and irritation.

Calcipotriol Cream should be stored with caution to maintain its integrity and effectiveness. It is recommended to keep the cream in a cool and dry place, preferably at room temperature, ensuring it is not exposed to direct sunlight or extreme heat. Maintain the original packaging to prevent contamination and protect the medication. Regularly check the expiration date, and if the cream has passed its expiry, do not use it and dispose of it appropriately. When disposing of unused or expired Calcipotriol Cream, avoid flushing it down the toilet or sink; instead, consult a pharmacist or local waste management guidelines for safe disposal methods. Keep the cream out of children's reach to prevent accidental contact or ingestion.

Following are the quick tips for Calcipotriol Cream:

• Apply a thin layer to affected skin areas once or twice daily as directed by your doctor.
• Wash your hands after application to avoid accidental contact with eyes or sensitive areas.
• Use only on the skin and not on mucous membranes or open wounds.
• Avoid applying the cream to areas of skin not affected by psoriasis.
• Do not cover treated areas with airtight dressings or bandages.
• Discontinue use and consult your doctor if irritation or severe skin reactions occur.
• Store the cream at room temperature, away from direct sunlight and moisture.