Calcium Gluconate 1gm 10ml Inj 50 S

Calcium gluconate injection works by providing a source of calcium ions, which play a crucial role in various physiological processes. When administered, calcium gluconate rapidly dissociates into calcium and gluconate ions. Calcium ions are essential for maintaining normal cardiac function, nerve impulse transmission, muscle contraction, and blood coagulation. They help stabilize cardiac cell membranes, regulate heart rhythm, and improve cardiac contractility. Calcium gluconate can also help correct calcium deficiencies, especially in conditions where there is hypocalcemia or calcium depletion, such as hypoparathyroidism or severe calcium loss due to renal failure or hyperphosphatemia. By replenishing calcium levels, calcium gluconate helps restore normal physiological functions and prevents or treats conditions associated with calcium imbalances.

Calcium gluconate

Calcium gluconate is a calcium salt.

Injection

The following are the uses of Calcium gluconate injection:

• Used for treating calcium deficiencies, especially in conditions like hypocalcemia.
• Used for managing cardiac arrhythmias, helping to restore regular heart rhythms.
• Used for hyperkalemia treatment, reducing high potassium levels in the blood.
• Used for hypermagnesemia, counteracting high magnesium levels.
• Used for managing calcium-channel blocker overdoses, as an effective antidote.
• Used for preventing hypocalcemic tetany, a condition causing muscle spasms.
• Used for improving calcium levels during renal failure, supporting bone health.
• Used for enhancing calcium absorption in certain gastrointestinal disorders.

In the case of an overdose of Calcium Gluconate injection, the primary symptoms may include extreme fatigue, confusion, and a significant drop in blood pressure. Other signs could manifest as nausea, vomiting, and a rapid or irregular heartbeat. It is imperative to promptly seek medical assistance and provide healthcare professionals with comprehensive details regarding the dosage and timing of the overdose. This information is vital for effective treatment and management of potential complications.

In the case of a missed dose of Calcium Gluconate injection, it is important to administer the missed dose as soon as you remember. However, if it is almost time for your next scheduled dose, skip the missed dose and continue with your regular dosing schedule. Do not double the dose to make up for a missed one. If you have any concerns or questions regarding missed doses, it is best to consult your healthcare provider for guidance on how to proceed safely.

To administer the Calcium Gluconate injection, clean the injection site with an alcohol wipe, insert the needle at a 90-degree angle, and slowly inject the prescribed dose, ensuring the entire amount is delivered; follow this by gently applying pressure with a sterile pad to the injection site after withdrawal.

Following are the conditions/situations when Calcium gluconate injection should not be administered:

• Must not be used in individuals with a known allergy or hypersensitivity to Calcium gluconate or any of its excipients.
• Contraindicated in patients with severe renal impairment or kidney failure, as it can lead to calcium overload.
• Should not be used to treat calcium deficiencies caused by high phosphate levels or vitamin D disorders.
• Not recommended for patients with hypercalcemia (high blood calcium levels) or conditions that may lead to calcium accumulation in tissues.
• Contraindicated in digitalis (digoxin) toxicity, as it can worsen heart rhythm problems.
• Should not be administered intravenously too rapidly, as it may cause cardiac arrest.
• Not suitable for patients with impaired heart function or congestive heart failure.

The side effects of Calcium Gluconate injection may include:

• Nausea and vomiting.
• Local pain, swelling, or irritation at the injection site.
• Hypocalcemia (low calcium levels in the blood), which can cause symptoms like muscle cramps, tingling, or numbness.
• Hypercalcemia (high calcium levels in the blood), leading to symptoms such as constipation, fatigue, and increased thirst.
• Hypotension (low blood pressure).
• Arrhythmias (irregular heart rhythms).
• Calcium deposits in tissues, especially in patients with renal impairment.
• Allergic reactions, including rash, itching, and difficulty breathing.

Following are the precautions and warnings for Calcium Gluconate Injection:

• Not recommended for intravenous use due to the risk of tissue necrosis and vascular irritation; use with extreme caution and only if the benefits outweigh the risks.
• Rapid intravenous injection must be avoided as it can lead to severe hypotension, bradycardia, arrhythmias, and even cardiac arrest.
• Intramuscular injection should be done slowly and with caution to minimize pain and tissue damage.
• Patients with impaired renal function or kidney disease should be closely monitored as calcium gluconate can affect kidney function.
• Calcium levels should be monitored regularly, especially in patients with hypercalcemia, as this medication can elevate calcium levels.
• May interact with other medications, particularly cardiac glycosides and calcium channel blockers, so healthcare professionals should be informed of all medications the patient is taking.
• Not recommended for use in patients with digitalis toxicity, ventricular fibrillation, or severe hyperkalemia.
• Should be used with caution in elderly patients and those with cardiovascular diseases as it may affect heart function.

Following are the drug interactions for Calcium Gluconate Injection:

• Can reduce the effectiveness of cardiac glycosides like Digoxin, requiring close monitoring of serum levels.
• Concurrent use with calcium channel blockers may lead to additive effects and potential cardiovascular complications.
• Antibiotics such as tetracyclines, quinolones, and fluoroquinolones may have decreased absorption when administered with calcium gluconate.
• Thiazide diuretics can increase calcium retention, leading to hypercalcemia when used with calcium gluconate.
• Bisphosphonates, often used for osteoporosis, may have reduced absorption when taken with calcium supplements.
• Phenytoin, an anticonvulsant, can have decreased absorption when given with calcium gluconate.
• Corticosteroids and calcium gluconate together may increase the risk of gastrointestinal side effects and calcium-related complications.

Following are the food interactions for Calcium gluconate injection:

• Avoid consuming foods rich in oxalic acid (like spinach, rhubarb, and sweet potatoes) or phytic acid (found in whole grains and legumes) as these compounds can bind to calcium, reducing its absorption.
• High-fiber foods can potentially decrease the absorption of calcium. It is best to separate calcium-rich meals from high-fiber foods by a few hours.
• Calcium supplements or calcium-fortified foods should be consumed with care as excessive calcium intake can lead to constipation, kidney stones, and other health issues.
• Ensure adequate vitamin D intake, as it aids in calcium absorption. Sunlight exposure and vitamin D-rich foods like fatty fish and egg yolks can help in this regard.
• Avoid excessive consumption of sodium (salt), as it can increase calcium excretion through urine, leading to a potential calcium imbalance.
• Dairy products, such as milk, cheese, and yogurt, are excellent sources of dietary calcium and can be consumed to ensure adequate calcium levels.
• Green leafy vegetables like broccoli, kale, and bok choy are rich in calcium and can be included in the diet to maintain calcium levels.
• Certain types of fish, such as sardines and salmon, provide a good amount of calcium, especially when eaten with their soft bones.

Calcium Gluconate Injection should be stored in a controlled environment, preferably between 20°C and 25°C (68°F and 77°F), away from direct sunlight and moisture. It is crucial to keep the injection in its original packaging, ensuring the seal is intact, to maintain sterility. Avoid freezing the solution as it may affect its potency. Always check the expiration date before use, and never use the injection if it has expired. For disposal, do not discard Calcium Gluconate Injection in regular household waste or pour it down the drain. Contact your healthcare provider or pharmacist for instructions on proper disposal methods to ensure environmental safety. Keep this medication out of the sight and reach of children to prevent accidental exposure.

Following are the quick tips for Calcium Gluconate Injection:

• Administer the injection under medical supervision for the treatment of calcium deficiencies.
• Ensure the injection is given into a vein or as directed by the healthcare professional.
• Do not inject into muscles or under the skin unless specifically instructed by a healthcare provider.
• Check the solution for any discoloration or particles before use, and discard if any are present.
• Infuse the injection slowly to minimize the risk of side effects.
• Avoid rapid infusion as it may lead to calcium overload and potential complications.
• Report any signs of allergic reaction or severe side effects to your healthcare provider immediately.