Calcium-P 30 Tablets

Calcitriol, the active form of vitamin D, exerts its effects primarily by binding to the vitamin D receptor (VDR) found in various target cells throughout the body. Upon binding to the VDR, calcitriol forms a complex that acts as a transcription factor, regulating gene expression. This complex influences the absorption and utilization of calcium and phosphate in the intestine, kidneys, and bones. In the intestine, it enhances calcium and phosphate absorption by increasing the expression of calcium and phosphate transport proteins. Calcitriol promotes osteoclast-mediated bone resorption and stimulates the release of calcium and phosphate from bone. Additionally, it enhances renal tubular reabsorption of calcium and inhibits phosphate excretion, thereby increasing calcium and phosphate levels in the blood. This mechanism of action is crucial for maintaining calcium homeostasis, promoting bone mineralization, and supporting overall bone health.

Calcitriol

Vitamin D analog

Tablet

The following are the uses of Calcitriol Tablet:

• Used for treating and preventing low calcium levels in the blood.
• Used for managing bone diseases like osteoporosis, promoting bone strength and density.
• Used for correcting calcium deficiency in conditions like hypoparathyroidism.
• Used for regulating abnormal calcium levels in kidney diseases.
• Used for supporting bone growth and development in certain types of rickets.
• Used for maintaining bone health during long-term steroid therapy.
• Used for enhancing calcium absorption, especially in digestive disorders.

In the case of an overdose of Calcitriol Tablets, it is essential to recognize the potential symptoms and act promptly. Overdose symptoms may include nausea, vomiting, increased thirst, and frequent urination. If you suspect an overdose, contact a healthcare professional or a poison control center immediately for guidance. They will provide specific instructions for managing the overdose, which may include immediate medical intervention and supportive care.

In the case of a missed dose of Calcitriol Tablet, it is important to take the medication as soon as you remember. However, if it is almost time for your next dose, skip the missed dose and continue with your regular dosing schedule. Do not take a double dose to make up for a missed one, as this may increase the risk of side effects. If you frequently miss doses, consider setting reminders or using a pill organizer to help you stay on track with your medication routine. It is crucial to maintain consistency in taking this medication as prescribed by your healthcare provider.

To take Calcitriol Tablets, place the tablet on your tongue and swallow it with a glass of water, preferably at the same time each day, following the dosage instructions provided by your healthcare professional, who will determine the correct dosage based on your condition and response to treatment.

Following are the conditions or circumstances when Calcitriol Tablet should not be used:

• Should not be used in patients with hypercalcemia (high calcium levels in the blood) or conditions causing hypercalcemia, such as primary hyperparathyroidism.
• Contraindicated in patients with evidence of vitamin D toxicity.
• Not recommended for individuals with elevated calcium levels due to sarcoidosis.
• Should not be used in patients with impaired kidney function or those on dialysis, as it can lead to calcium and phosphate imbalance.
• Contraindicated in patients with a known allergy or hypersensitivity to Calcitriol or any of its excipients.
• Not suitable for individuals with idiopathic hypercalciuria (excessive calcium in urine without a known cause).
• Should be avoided in patients with a history of kidney stones or conditions that increase the risk of kidney stone formation.
• Not recommended for long-term use in infants with chronic kidney disease.

The side effects of Calcitriol Tablet may include:

• Nausea and vomiting.
• Weakness or fatigue.
• Dry mouth or increased thirst.
• Muscle or joint pain.
• Constipation or diarrhea.
• Metallic taste in the mouth.
• Loss of appetite.
• Increased urination.

Here are the precautions and warnings for Calcitriol Tablet:

• Not recommended for individuals with known hypersensitivity or allergy to Calcitriol or any of its components.
• Patients with kidney disease or impairment should use with caution as it can affect calcium metabolism and may require dosage adjustments.
• Regular monitoring of calcium levels in the blood is necessary, as excessive calcium levels can lead to serious side effects.
• Avoid excessive doses, as it may cause hypercalcemia, leading to symptoms like nausea, vomiting, constipation, and muscle weakness.
• Patients with a history of kidney stones should exercise caution, as Calcitriol can increase the risk of stone formation.
• Pregnant and breastfeeding women should consult their doctor, as Calcitriol can affect fetal development and may pass into breast milk.
• Keep out of reach of children, as accidental ingestion may result in serious side effects.

Following are the drug interactions for Calcitriol Tablet:

• Anticonvulsants like phenytoin, phenobarbital, and carbamazepine can decrease the effectiveness of Calcitriol by increasing its metabolism.
• Taking Calcitriol with digoxin may increase the risk of digoxin toxicity, requiring close monitoring of digoxin levels.
• Calcium-containing antacids may reduce the absorption of Calcitriol, so they should be taken at different times.
• Corticosteroids such as prednisone may increase calcium loss from bones, potentially reducing the effectiveness of Calcitriol.
• Thiazide diuretics, e.g., hydrochlorothiazide, can increase calcium retention, leading to hypercalcemia when used with Calcitriol.
• Mineral oil or other laxatives, if used long-term, may reduce the absorption of fat-soluble vitamins like Calcitriol.
• Drugs that inhibit the CYP3A4 enzyme, such as ketoconazole and clarithromycin, can increase Calcitriol levels, leading to hypercalcemia.

Following are the food interactions for Calcitriol Tablet:

• Grapefruit and grapefruit juice should be consumed with caution as they may increase the levels of Calcitriol in the blood, leading to potential hypercalcemia.
• High-calcium foods like dairy products, spinach, and calcium-fortified foods should be monitored and consumed in moderation. Excessive intake can increase calcium levels in the blood.
• Vitamin D-rich foods such as fatty fish, egg yolks, and liver can further elevate vitamin D levels, requiring careful monitoring.
• Avoid excessive alcohol consumption as it may interfere with calcium metabolism and increase the risk of hypercalcemia.
• Maintain a balanced diet, as Calcitriol can increase calcium absorption from food, and excessive intake of calcium-rich foods may lead to complications.
• Consider limiting foods high in phosphorus, as Calcitriol can enhance phosphorus absorption, and elevated phosphorus levels may have health implications.
• Avoid excessive vitamin A intake from sources like liver, as it may interact with Calcitriol, affecting bone health.
• Always consult a healthcare professional for personalized advice on diet and medication interactions.

Calcitriol Tablets should be stored in a secure and dry location, away from direct sunlight and moisture. Maintain the original packaging, ensuring it remains tightly sealed to prevent contamination. Avoid storing the tablets in the bathroom or near heat-emitting appliances to maintain their integrity. Regularly check the expiration date, and if the medication has passed its expiry, safely dispose of it. Do not flush or pour the tablets down the drain; consult your pharmacist or local waste management guidelines for appropriate disposal methods. Always keep medications out of children's reach to prevent accidental consumption. Proper storage and disposal practices are crucial for the effectiveness of the medication and the safety of those around you.

Following are the quick tips for Calcitriol Tablet:

• Consult your doctor for the right dosage and duration of treatment.
• Take the tablet as directed, usually once daily or as prescribed.
• Swallow the tablet whole; do not crush, chew, or break it.
• Consume the tablet with a full glass of water for easy swallowing.
• Take the tablet on an empty stomach, at least 1 hour before or 2 hours after a meal.
• Avoid taking it with dairy products, as they may interfere with absorption.
• Regularly monitor your calcium levels during treatment.