CALCIUM RESONIUM POWDER IMP

Calcium Resonium Powder, also known as calcium polystyrene sulfonate, acts as a cation-exchange resin. It exchanges sodium ions for calcium ions in the gastrointestinal tract, thereby reducing the absorption of sodium and increasing calcium excretion. This mechanism is crucial in conditions where excess sodium needs to be eliminated, such as in hyperkalemia or certain kidney disorders. By binding to potassium ions in the gastrointestinal tract, Calcium Resonium Powder helps to lower the overall potassium levels in the body, making it an effective treatment for hyperkalemia. This selective ion exchange process is the primary mode of action for this medication.

CALCIUM RESONIUM

Ion-exchange resins

Powder

The following are the uses of CALCIUM RESONIUM Powder:

• Used for treating high potassium levels in the blood, a condition known as hyperkalemia.
• Used for regulating fluid balance and managing edema (excess fluid retention).
• Used for managing heart failure by reducing fluid buildup and improving heart function.
• Used for controlling high blood pressure, particularly in cases of hypertension.
• Used for treating certain kidney disorders where calcium and potassium levels need adjustment.
• Used for preventing and managing hypercalcemia (low calcium levels) in specific medical scenarios.
• Used for stabilizing cardiac function in emergency situations, especially related to electrolyte imbalances.

In the case of an overdose of CALCIUM RESONIUM Powder, symptoms may include nausea, vomiting, constipation, and in severe cases, calcium deposits in tissues. Immediate treatment involves inducing vomiting or using activated charcoal to prevent further absorption. It is crucial to seek medical advice, as healthcare professionals may recommend monitoring kidney function and providing supportive care to manage symptoms effectively. Prompt medical intervention can help prevent potential complications.

In the case of a missed dose of CALCIUM RESONIUM Powder, it is important to take the dose as soon as you remember. However, if it is almost time for your next scheduled dose, skip the missed dose and continue with your regular dosing schedule. Do not double the dose to make up for a missed one, as this may increase the risk of side effects. If you miss multiple doses, contact your healthcare professional for advice on how to proceed, as they can provide guidance based on your specific medical condition and treatment plan.

To use CALCIUM RESONIUM Powder, dissolve the prescribed amount in a glass of water and drink the entire mixture, ensuring you follow the dosage instructions provided by your healthcare professional.

Following are the conditions/situations when CALCIUM RESONIUM Powder should not be used:

• Should not be administered to individuals with a known hypersensitivity or allergy to calcium polystyrene sulfonate or any of its excipients.
• Contraindicated in patients with severe hypercalcemia (high levels of calcium in the blood).
• Not recommended for individuals with hypocalcemia (low levels of calcium in the blood).
• Should not be used in patients with severe kidney disease or individuals on dialysis.
• Contraindicated during pregnancy and breastfeeding, unless the potential benefits outweigh the risks.
• Not suitable for children below 18 years of age, as the safety and efficacy have not been established in this population.
• Avoid use in patients with severe constipation or bowel obstruction.
• Should not be administered to patients with a known history of gastrointestinal obstruction or perforation.
• Contraindicated in individuals with a history of intestinal surgery or conditions that affect the normal movement of the intestines.

The side effects of CALCIUM RESONIUM Powder may include:

• Constipation
• Nausea and vomiting
• Abdominal pain or discomfort
• Dry mouth
• Loss of appetite
• Fatigue and weakness
• Increased thirst
• Electrolyte imbalances (such as high calcium levels in the blood)

Following are the precautions and warnings for CALCIUM RESONIUM Powder:

• Do not use if you are allergic to calcium or any other ingredients in the powder.
• This medication should be used with caution in patients with kidney disease or a history of kidney stones. Regular monitoring of kidney function is advised.
• It may cause constipation, so ensure you drink plenty of fluids and maintain a fiber-rich diet.
• Patients with heart disease, high blood pressure, or diabetes should use it with caution and under medical supervision.
• Elderly individuals may be more susceptible to side effects, particularly those related to the digestive system.
• Not recommended for long-term use without medical supervision due to the potential for calcium imbalances.
• If you experience any unusual symptoms or side effects, such as severe constipation, abdominal pain, or irregular heartbeat, seek medical attention immediately.

Following are the drug interactions for CALCIUM RESONIUM Powder:

• May decrease absorption of tetracyclines, fluoroquinolones, and phenytoin when taken concurrently. Separate administration by at least 3 hours.
• Bisphosphonates, quinolones, and levothyroxine absorption may be reduced, so separate administration by at least 2 hours.
• Thiazide diuretics' effects can be decreased, leading to reduced blood pressure control.
• May decrease absorption of iron supplements, so separate administration by at least 2 hours.
• Antacids containing aluminum or magnesium can reduce the absorption of Calcium Resonium. Take them at different times.
• Concomitant use with cardiac glycosides may increase the risk of cardiac arrhythmias.
• May decrease the effectiveness of oral contraceptives, requiring additional contraceptive measures.

Following are the food interactions for CALCIUM RESONIUM Powder:

• Avoid consuming foods high in fat while taking this medication as it may decrease the absorption of the drug, potentially reducing its effectiveness.
• Stay well-hydrated and drink plenty of fluids throughout the day to prevent constipation, a common side effect of this medication.
• Limit your intake of dairy products like milk, cheese, and yogurt as they can decrease the absorption of calcium.
• Avoid excessive consumption of foods rich in oxalic acid like spinach, rhubarb, and beets as they can bind with calcium and reduce its effectiveness.
• Avoid high-fiber foods like whole grains, legumes, and certain fruits and vegetables, as they may interfere with the medication's binding properties.
• Reduce your intake of foods with high sodium content, including processed and packaged foods, as they can decrease the effectiveness of the medication.
• Consider limiting your intake of foods rich in vitamin D and magnesium, as excessive amounts can lead to an imbalance in calcium levels when combined with the medication.
• Always take the medication with a full glass of water to ensure proper dissolution and absorption.

Calcium Resonium Powder should be stored in a cool and dry area, preferably in its original packaging, to maintain its stability and effectiveness. Protect the powder from exposure to direct sunlight, moisture, and heat sources like radiators or ovens, as these conditions can degrade the medication. Always check the expiration date before use and never use the powder beyond its expiry. Dispose of any unused or expired powder responsibly; do not flush it down the toilet or pour it into drains. Consult your pharmacist or local waste management guidelines for safe disposal methods. Keep the powder out of children's reach to prevent accidental ingestion.

Following are the quick tips for CALCIUM RESONIUM Powder:

• Mix the powder with water as directed on the package or by your healthcare professional.
• Stir the mixture well until it forms a smooth, uniform consistency.
• Consume the entire mixture immediately after preparation for best results.
• Take the dose with a full glass of water to aid in swallowing and absorption.
• Do not crush or chew the powder; ensure you swallow it completely.
• Store the powder in a cool, dry place, away from direct sunlight and moisture.
• Consult your doctor if you have any pre-existing medical conditions or are taking other medications.