CALENDULA CREAM

The mechanism of action of Calendula officinalis (Marigold) Aerial Parts in a 5.0% cream formulation is primarily attributed to its diverse phytochemical constituents. The cream contains various bioactive compounds, including flavonoids, triterpenoids, and carotenoids, which contribute to its therapeutic effects. These compounds exhibit anti-inflammatory properties by modulating the production of pro-inflammatory mediators such as cytokines and prostaglandins. Triterpenoids, in particular, are known for their ability to promote wound healing and skin regeneration by stimulating collagen synthesis and enhancing tissue repair. Additionally, the flavonoids in Calendula possess antioxidant properties, helping to neutralize free radicals and protect the skin from oxidative damage. The combined actions of these phytochemicals contribute to the overall anti-inflammatory, wound-healing, and skin-soothing effects of Calendula officinalis Aerial Parts in the cream formulation.

Topical anti-inflammatory

Cream

The following are the uses of Calendula officinalis (Marigold) Aerial Parts MT 5.0% Cream:

• Used for soothing and calming irritated skin.
• Used to promote skin healing and reduce inflammation.
• Used for moisturizing dry or chapped skin.
• Used for minor cuts, scrapes, and burns.
• Used in treating diaper rash and skin rashes.
• Used for reducing the appearance of minor scars and stretch marks.
• Used for providing antioxidant protection to the skin.
• Used as a natural remedy for minor skin ailments.

In the case of an overdose of Calendula officinalis (Marigold) Aerial Parts MT 5.0% Cream, the primary concern is skin irritation and possible allergic reactions. Symptoms may include redness, itching, or swelling at the application site. If ingested, it could lead to gastrointestinal discomfort, nausea, or vomiting. Treatment involves immediate discontinuation of the cream and thorough rinsing of the affected area with water. Medical attention should be sought if symptoms persist or worsen, especially if there are signs of a severe allergic reaction.

In the case of a missed dose of Calendula Officinalis cream, it is generally recommended to apply the cream as soon as you remember. However, if it is almost time for your next scheduled application, skip the missed dose and continue with your regular schedule. Do not apply extra cream to make up for the missed dose, as this may increase the risk of skin irritation. It is advisable to use the cream as directed and consult a healthcare professional if you have any concerns or if you miss multiple doses, especially if you are using it for wound healing or skin conditions.

To apply Calendula officinalis (Marigold) Aerial Parts MT 5.0% Cream, gently cleanse and dry the affected area, then apply a thin layer of the cream 2-3 times daily or as directed by your healthcare professional.

Following are the conditions or situations when Calendula officinalis (Marigold) Aerial Parts MT 5.0% Cream should not be applied:

• Avoid using this cream if you have a known skin sensitivity or allergy to Calendula officinalis or any other ingredients in the cream.
• Do not use on open wounds, deep cuts, or severe burns.
• Contraindicated for individuals with severe skin conditions like eczema, psoriasis, or severe dermatitis.
• Do not apply near the eyes, mouth, or any mucous membranes.
• Avoid using on areas with broken skin or severe skin infections.
• Not suitable for infants or very young children without medical advice.
• Discontinue use if it causes severe skin irritation, redness, or swelling.

The potential side effects of Calendula officinalis (Marigold) Aerial Parts MT 5.0% Cream may include:

• Skin irritation or redness at the application site.
• Itching or rash.
• Mild burning sensation.
• Dryness or flakiness of the skin.
• Allergic reactions (such as hives or swelling).
• Increased sensitivity to sunlight.
• Prolonged use may cause skin discoloration.
• In rare cases, contact dermatitis.

Following are the precautions and warnings for Calendula officinalis (Marigold) Aerial Parts MT 5.0% Cream:

• Do not use if you are allergic to any of the ingredients, including marigold or other related plants.
• Avoid contact with eyes and mucous membranes. If contact occurs, rinse thoroughly with water.
• For external use only. Do not ingest or apply to open wounds.
• Keep out of reach of children. Store in a cool, dry place away from direct sunlight.
• Discontinue use if skin irritation, redness, or rash occurs. Consult a healthcare professional if symptoms persist.
• Do not use on broken or infected skin.
• Consult a healthcare professional if you are pregnant, breastfeeding, or have any medical conditions before using this product.

Following are the drug interactions for Calendula officinalis (Marigold) Aerial Parts MT 5.0% Cream:

• It may interact with topical medications containing Tretinoin, potentially causing skin irritation or reducing the effectiveness of tretinoin.
• Calendula can increase the skin penetration of 5-fluorouracil, possibly enhancing its effects.
• When used with other topical agents like steroids or analgesics, the absorption and effect of these drugs may be altered.
• The effectiveness of sunscreen agents may be reduced when applied after using Calendula cream.
• It may enhance the absorption of other medications applied to the same skin area, such as antifungal or antibiotic creams.
• Calendula's potential anti-inflammatory properties could theoretically interact with oral anti-inflammatory medications.
• Due to its potential immune-modulating effects, Calendula might theoretically interact with immunosuppressant drugs.

Following are the food interactions for Calendula officinalis (Marigold) Aerial Parts MT 5.0% Cream:

• Avoid consuming excessive amounts of citrus fruits or juices, especially grapefruit, as they may increase the absorption of Calendula and potentially enhance its effects.
• Alcohol-based products might increase the skin's sensitivity, so it's advisable to limit alcohol consumption while using Calendula cream.
• Dairy products, especially milk, can interact with Calendula's bioactive compounds, potentially reducing their effectiveness. Consider separating milk consumption from the application of the cream.
• Spicy foods can increase skin sensitivity and may cause discomfort when using Calendula cream, especially if applied to sensitive areas.
• Garlic and onion, known for their blood-thinning properties, might enhance the anti-inflammatory effects of Calendula when consumed together.
• Green leafy vegetables rich in vitamin K, like spinach, might interact with Calendula's potential blood-thinning effects, so consistent consumption of these vegetables should be considered.
• Foods high in vitamin C, such as oranges and bell peppers, can support the healing properties of Calendula and may enhance its benefits when consumed regularly.
• Fatty fish, rich in omega-3 fatty acids, can complement Calendula's anti-inflammatory actions, making this dietary addition beneficial.

Calendula officinalis (Marigold) Aerial Parts MT 5.0% Cream should be stored in a cool and dry environment, preferably at room temperature, ensuring it is protected from direct sunlight and moisture. Store the cream in its original packaging, tightly sealed, to maintain its integrity and prevent contamination. It is crucial to avoid exposing the cream to heat sources like radiators or stoves, as extreme temperatures can impact its quality. Always check the expiration date before using the cream, and dispose of any leftover or expired product responsibly. Do not dispose of it in drains or toilets; instead, seek advice from a pharmacist or healthcare professional for appropriate disposal methods. Keep the cream out of children's reach to prevent accidental ingestion.

Here are the quick tips for Calendula Officinalis Aerial Parts Cream:

• Apply a thin layer of the cream to the affected area as needed, typically 2-3 times daily.
• Clean and dry the skin before application for better absorption.
• Gently massage the cream in a circular motion until it is absorbed.
• Avoid contact with eyes and mucous membranes.
• Wash your hands after application, especially before handling contact lenses or touching sensitive areas.
• Store the cream at room temperature, away from direct sunlight and moisture.
• Discontinue use if irritation or rash occurs and consult a healthcare professional.