Calfol (1mg) 100 Tablets

Paracetamol, the active ingredient in the 1000mg tablet, exerts its analgesic and antipyretic effects primarily through its action on the central nervous system. It is believed to inhibit the synthesis of prostaglandins, which are involved in mediating pain and inflammation. Paracetamol acts by blocking cyclooxygenase (COX) enzymes, particularly COX-2, in the brain and spinal cord, reducing the production of prostaglandin E2, which is responsible for transmitting pain signals. This mechanism helps to alleviate pain and reduce fever without directly targeting peripheral inflammation, making it effective for mild to moderate pain and fever management.

Analgesic, antipyretic.

Tablet

The following are the uses of Paracetamol 1000mg Tablet:

• Used for relieving mild to moderate pain such as headaches, toothaches, and menstrual cramps.
• Used to reduce fever and manage symptoms of colds and flu.
• Effective in reducing discomfort from minor injuries and muscle aches.
• Can be taken to ease pain and inflammation associated with arthritis.
• Helps manage pain post-surgery or medical procedures.
• Used for treating pain and fever in various medical conditions.
• Provides temporary relief from body aches and pains.

In the case of an overdose of Paracetamol 1000mg Tablets, individuals may experience symptoms such as nausea, vomiting, abdominal pain, and potential liver damage. Prompt medical intervention is necessary to manage the overdose effectively. The severity of the effects can vary depending on the amount ingested, with higher doses potentially leading to more serious consequences. It is crucial to seek medical advice or contact a healthcare professional immediately if an overdose is suspected, as they can provide guidance and ensure appropriate treatment. Timely action can help mitigate the risks associated with Paracetamol overdose.

In the case of a missed dose of Paracetamol 1000mg Tablet, it is important to take the medication as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue with your regular dosing schedule. Do not take a double dose to make up for the missed one. If you have missed multiple doses, consult your healthcare provider for guidance on how to safely resume your medication. It is generally recommended to take the missed dose within a few hours of the intended time, but always follow the advice of your doctor or pharmacist.

To take Paracetamol 1000mg Tablet, swallow the tablet whole with a glass of water, preferably with or after a meal, following the dosage instructions provided by your healthcare professional, typically one tablet every 4 to 6 hours, or as directed by your doctor.

Here are the conditions or situations when Paracetamol 1000mg Tablet should not be taken:

• Avoid if you have severe liver or kidney disease, as Paracetamol is primarily processed by the liver and kidneys.
• Not suitable for individuals with a known allergy or hypersensitivity to Paracetamol or any of the tablet's components.
• Should not be used to treat pain associated with inflammation, such as in arthritis, as it lacks anti-inflammatory properties.
• Avoid using Paracetamol 1000mg Tablet if you have a history of gastrointestinal bleeding or ulcers, as it may increase the risk of bleeding.
• Not recommended for individuals with G6PD (Glucose-6-Phosphate Dehydrogenase) deficiency, as Paracetamol may cause hemolysis (breakdown of red blood cells).
• Should not be used to treat fever in children and infants without medical advice, as the dosage may need to be adjusted based on weight and age.
• Contraindicated in individuals with severe heart disease, as high doses of Paracetamol may affect cardiovascular function.
• Avoid using Paracetamol 1000mg Tablet if you are consuming large amounts of alcohol, as it may increase the risk of liver damage.
• Not suitable for individuals with a history of metabolic disorders affecting Paracetamol metabolism.
• Should not be combined with other medications containing Paracetamol to avoid overdose.

The side effects of Paracetamol 1000mg Tablet may include:

• Nausea and vomiting
• Stomach pain or discomfort
• Loss of appetite
• Skin rash or itching
• Dark-colored urine
• Yellowing of eyes or skin (jaundice)
• Allergic reactions (hives, swelling, difficulty breathing)
• Liver damage (in rare cases with prolonged use)

Following are the precautions and warnings for Paracetamol 1000mg Tablet:

• Do not exceed the recommended dosage, as excessive use can lead to liver damage.
• Individuals with liver or kidney disease should consult a doctor before use, as dosage adjustments may be necessary.
• Avoid long-term use without medical supervision, as prolonged use may cause kidney or liver problems.
• Inform your doctor if you are taking other medications, especially those affecting the liver, to prevent potential drug interactions.
• Stop use and seek medical attention if you experience skin rash, itching, or any signs of an allergic reaction.
• Paracetamol should be used with caution in individuals with alcohol dependence or chronic malnutrition.
• Not recommended for long-term pain management; consult a healthcare professional for alternative options.

Following are the drug interactions for Paracetamol 1000mg Tablet:

• Prolonged use with opioids like codeine can lead to increased risk of liver damage.
• May reduce the effectiveness of antihypertensive medications, such as beta-blockers or ACE inhibitors.
• Paracetamol can increase the risk of bleeding when taken with anticoagulants like warfarin or antiplatelet drugs.
• Concomitant use with certain anticonvulsants, such as carbamazepine, may increase the risk of liver toxicity.
• Interaction with oral diabetes medications can affect blood glucose control.
• Can potentially decrease the effectiveness of certain antibiotics, like rifampicin.
• Use with other central nervous system depressants (e.g., benzodiazepines, barbiturates) may enhance sedation and respiratory depression.

Following are the food interactions for Paracetamol 1000mg Tablet:

• Avoid excessive alcohol consumption while taking this medication, as it can increase the risk of liver damage, especially with long-term use.
• Grapefruit and grapefruit juice should be consumed with caution as they may affect the liver's ability to process Paracetamol, potentially leading to increased drug levels in the body.
• High-fat meals may slightly delay the absorption of Paracetamol, but this is generally not clinically significant.
• Caffeine-containing beverages, Limit excessive intake of coffee, tea, or energy drinks, as caffeine can increase the metabolism of Paracetamol, potentially reducing its effectiveness.
• Ensure adequate fluid intake to prevent dehydration, especially when using Paracetamol for fever or pain associated with conditions causing fluid loss.
• Avoid fasting or prolonged periods without food, as Paracetamol absorption may be slightly reduced on an empty stomach.
• Avoid excessive consumption of foods containing high levels of tyramine (aged cheeses, cured meats, fermented foods) as Paracetamol may interact with monoamine oxidase inhibitors (MAOIs) present in these foods.
• There are no specific food restrictions with Paracetamol, but maintaining a balanced diet is advisable to support overall health and well-being.

Paracetamol 1000mg Tablets should be stored in a cool, dry place, preferably at room temperature, ensuring it remains away from direct sunlight and moisture. Keep the tablets in their original packaging, tightly sealed to maintain their integrity and prevent contamination. Avoid placing them in the bathroom or near heat sources, as temperature fluctuations can impact their effectiveness. Always check the expiration date before use, and properly dispose of any unused or expired tablets. Do not flush them down the toilet or drain; instead, consult your pharmacist for safe disposal methods. It is crucial to store medications securely, out of children's reach, to prevent accidental consumption.

Following are the quick tips for Paracetamol 1000mg Tablet:

• Consult a doctor before use, especially if you have liver or kidney issues.
• Take the tablet with a full glass of water, not crushed or chewed.
• Maintain a 4-6 hour gap between doses.
• Avoid alcohol consumption while taking this medication.
• Do not exceed the recommended dosage, as it may cause liver damage.
• Inform your doctor about all medications you are taking to prevent drug interactions.
• Store the tablets at room temperature, away from moisture and sunlight.