CALMAG TAB (30S)

Calcifediol, also known as 25-hydroxyvitamin D, is a prohormone that plays a crucial role in calcium homeostasis and bone health. Its primary mechanism of action involves the regulation of calcium and phosphate metabolism. When administered orally, calcifediol is rapidly absorbed and undergoes hydroxylation in the liver to form calcitriol, which is the active form of vitamin D. Calcitriol then binds to the vitamin D receptors (VDR) present in various target tissues, including the intestines, kidneys, and bones. This binding activates the VDR, leading to the modulation of gene expression. In the intestines, calcifediol enhances calcium and phosphate absorption by increasing the expression of calcium transport proteins. It also promotes bone mineralization by stimulating osteoblasts to produce osteocalcin, a protein essential for bone formation. Additionally, calcifediol regulates parathyroid hormone (PTH) secretion, inhibiting PTH release and reducing bone resorption by osteoclasts. This dual action on calcium absorption and bone metabolism contributes to its overall role in maintaining calcium balance and promoting skeletal health.

Calcifediol

Vitamin D Analogue

Tablet

The following are the uses of Calcifediol Tablet:

• Used for treating and preventing Vitamin D deficiency.
• Used for managing conditions like osteoporosis, where it helps improve bone density.
• Used to support bone health and muscle function in patients with chronic kidney disease.
• Used to regulate calcium and phosphate levels in the body.
• Used to enhance calcium absorption for stronger bones.
• Used for individuals with malabsorption syndromes who struggle to absorb nutrients.
• Used to reduce the risk of fractures and falls in the elderly.
• Used as a supplement during winter months when sunlight exposure is limited.

In the case of an overdose of Calcifediol Tablets, it is important to recognize the potential symptoms. These may include nausea, vomiting, increased thirst, and frequent urination. If you suspect an overdose, seek medical advice promptly. Treatment may involve managing symptoms and providing supportive care to ensure the patient's well-being. Prompt action can help mitigate the effects of an overdose and ensure a swift recovery.

In the case of a missed dose of Calcifediol Tablet, it is important to take the medication as soon as you remember. However, if it is almost time for your next scheduled dose, skip the missed dose and continue with your regular dosing schedule. Do not take a double dose to make up for the missed one. If you frequently miss doses, it is advisable to set reminders or use a pill organizer to help you stay on track with your medication routine. Always consult your healthcare provider if you have any concerns or questions regarding missed doses.

To take the Calcifediol Tablet, place the tablet on your tongue and swallow it with a glass of water, preferably with a meal or as directed by your healthcare professional, following the dosage instructions provided by your doctor or pharmacist.

Following are the conditions when Calcifediol Tablet should not be used:

• Should not be taken by individuals with a known allergy to vitamin D or any of its derivatives.
• Contraindicated in patients with high blood calcium levels (hypercalcemia).
• Not suitable for individuals with a history of kidney stones or kidney disease.
• Should be avoided in patients with uncontrolled high blood pressure.
• Not recommended for those with conditions causing excessive calcium absorption from the gut.
• Contraindicated in individuals with a history of calcification in blood vessels or soft tissues.
• Should not be used in patients with a known sensitivity to any of the tablet's inactive ingredients.
• Avoid use during pregnancy unless the potential benefits outweigh the risks.

The side effects of Calcifediol Tablet may include:

• Nausea and vomiting.
• Stomach pain.
• Dry mouth.
• Increased thirst.
• Frequent urination.
• Fatigue and weakness.
• Muscle or joint pain.
• Constipation or diarrhea.

Following are the precautions and warnings for Calcifediol Tablet:

• This medication is intended for patients with vitamin D deficiency and should not be used by individuals with normal vitamin D levels.
• Patients with a history of hypercalcemia or conditions like hyperparathyroidism, sarcoidosis, and kidney stones should exercise caution and consult a doctor before use.
• Regular monitoring of calcium and phosphate levels is necessary during treatment, especially for patients at risk of hypercalcemia.
• Not recommended for individuals with impaired kidney function or kidney disease, as it can lead to increased calcium levels.
• Those with a history of heart disease or conditions affecting calcium metabolism should use with caution and under medical supervision.
• Calcifediol can interact with other medications; inform your doctor about all medications you are taking to avoid potential interactions.
• This medication may cause dizziness; avoid driving or operating heavy machinery until you know how it affects you.

Following are the drug interactions for Calcifediol Tablet:

• Anticonvulsants like phenobarbital or phenytoin may reduce the effectiveness of calcifediol by increasing its metabolism.
• Thiazide diuretics can potentially decrease the excretion of vitamin D metabolites, leading to possible hypercalcemia.
• Calcium-containing products and calcium channel blockers can increase the risk of hypercalcemia when used with calcifediol.
• Cholestyramine can interfere with the absorption of calcifediol, reducing its effectiveness.
• Orlistat may decrease the absorption of fat-soluble vitamins, including vitamin D, potentially reducing calcifediol's effects.
• Ketoconazole, a potent CYP3A4 inhibitor, can increase calcifediol levels and lead to hypercalcemia.
• Dexamethasone, a corticosteroid, can decrease the activation of vitamin D, potentially reducing the effectiveness of calcifediol.

Following are the food interactions for Calcifediol Tablet:

• Avoid consuming high-calcium foods like dairy products, calcium-fortified foods, and calcium supplements immediately after taking the tablet, as they may interfere with absorption.
• Vitamin D-rich foods such as fatty fish, egg yolks, and liver should be consumed in moderation as excessive vitamin D intake can lead to hypercalcemia.
• Grapefruit and grapefruit juice may affect the metabolism of the medication and should be avoided to prevent potential drug interactions.
• Alcohol may decrease the effectiveness of Calcifediol and should be limited or avoided.
• Avoid high-fat meals as they may delay the absorption of the medication.
• Maintain a balanced diet with a variety of fruits, vegetables, and lean proteins to support overall health while taking this medication.
• Consult your healthcare provider for personalized dietary advice, especially if you have specific dietary restrictions or medical conditions.

Calcifediol Tablets should be stored in a secure and dry location, preferably in a medicine cabinet or a designated storage area, away from direct sunlight, moisture, and heat. It is crucial to keep the tablets in their original packaging, ensuring the container is tightly sealed to maintain their integrity and effectiveness. Do not remove the tablets from their blister packs unless you are about to take a dose. Regularly check the expiration date on the packaging, and dispose of any expired or unused tablets responsibly. Proper disposal is essential; do not throw them into the trash or flush them down the toilet. Contact your pharmacist or local waste management authority for guidance on safe disposal methods. Keep the medication out of children's reach to prevent accidental consumption, and always exercise caution when handling and storing Calcifediol Tablets.

Following are the quick tips for Calcifediol Tablet:

• Consult your doctor for the right dosage and duration based on your medical condition.
• Take the tablet orally, preferably with or after a meal to enhance absorption.
• Swallow the tablet whole without crushing or chewing for optimal results.
• Avoid consuming alcohol as it may interfere with the medication's effectiveness.
• Inform your doctor about all medications you are taking to prevent potential interactions.
• Store the tablets at room temperature, away from moisture and direct sunlight.
• Do not double the dose to make up for a missed one; continue with the regular schedule.
• Regularly monitor your vitamin D levels as advised by your healthcare provider.