Calpol 6 Plus (250mg/ml) 90ml Suspension

Paracetamol acts on the hypothalamus, a part of the brain that regulates body temperature. By affecting the hypothalamic heat-regulating center, it helps to lower fever. The exact mechanism of action of paracetamol is not completely understood, but it is believed to work by inhibiting the enzyme cyclooxygenase (COX), particularly COX-3, in the brain and spinal cord.

Analgesic

This medicine is used to treat:

• Pain
• Fever

Paracetamol Medication dosage recommendations are:

• Post-immunisation pyrexia - 60 mg for children 2-4 months. May give a 2nd dose of 60 mg after 4-6 hours if needed. Max - 240mg daily.
• Fever, Mild to moderate pain - For adults - 500-1,000 mg 4-6 hourly as needed. Max - 4,000 mg daily. For children - 3-5 months 60 mg, 6-23 months 120 mg, 2-3 years 180 mg, 4-5 years 240 mg, 6-7 years 240-250 mg, 8-9 years 360-375 mg, 10-11 years 480-500 mg, 12-15 years 480-750 mg, 16-17 years 500-1,000 mg. Doses are given 4-6 hourly as needed. Max - 4 doses daily.

Talk to a doctor at once if your child takes too much of this medicine, even if they seem well. This is because too much paracetamol can cause delayed, serious liver damage.

Give the next dose when needed, provided that the last dose was given at least 4 hours ago. Do not give a double dose.

Shake the bottle well before use. Measure the dose using the provided measuring device. Follow dosage instructions provided.

Do not give your child paracetamol suspension if:

• They have ever had a bad reaction to any of the ingredients.
• They are taking anything else containing paracetamol.
• They are between 2-3 months old and are taking this medicine for other causes of pain and fever and weigh less than 4 kg, or were born before 37 weeks.

The side effects of Paracetamol Suspension are as follows:

• Gastrointestinal discomfort
• Allergic reactions
• Skin rash
• Drowsiness

Here are some important precautions and warnings that patients should be aware of:

• Patients with G6PD deficiency should take special care when using the medication.
• Individuals with chronic alcoholism or malnutrition require close monitoring.
• Dehydrated patients or those with severe hypovolemia (especially with IV administration) should be carefully evaluated.
• Caution is advised for patients with renal and hepatic impairment.
• Extra care should be taken for neonates and children during treatment.
• Special precautions are necessary during pregnancy and lactation.

Drug interactions with paracetamol include:

• Alcohol (chronic use may increase the risk of liver damage)
• Anticoagulants (e.g., warfarin) (may enhance anticoagulant effect and increase bleeding risk)
• Other hepatotoxic drugs (e.g., isoniazid) (may increase the risk of liver damage)
• Carbamazepine (may increase the metabolism of paracetamol and reduce efficacy)
• Phenytoin (may increase the metabolism of paracetamol).

Store at room temperature in a tightly closed container. Dispose of unused or expired medication by returning it to a pharmacy for safe disposal.