Calpsor-B (50mcg/0.5mg) 30ml Creamy Lotion

Calcipotriol's primary mechanism of action involves its ability to modulate gene expression by binding to specific nuclear receptors called vitamin D receptors (VDRs). These receptors are present in various cells, including keratinocytes in the skin. Upon binding to VDRs, calcipotriol regulates the transcription of genes involved in cell proliferation and differentiation. It inhibits the excessive proliferation of keratinocytes, which is a hallmark of psoriasis, and promotes their differentiation into mature epidermal cells. This dual action helps normalize the skin cell turnover cycle, reducing the formation of psoriatic plaques. Calcipotriol also exerts anti-inflammatory effects by downregulating the production of pro-inflammatory cytokines and reducing the infiltration of inflammatory cells into the skin lesions. By targeting these cellular processes, calcipotriol helps alleviate the symptoms of psoriasis and promotes the restoration of a healthier skin structure.

Calcipotriol

vitamin D analogue.

Lotion

The following are the uses of Calcipotriol Lotion:

• Used for the treatment of psoriasis, effectively reducing skin inflammation and slowing down skin cell growth.
• Used for managing plaque psoriasis, providing relief from itching and scaling.
• Used for topical application to treat skin lesions and improve overall skin appearance.
• Used for its ability to control the overproduction of skin cells, common in psoriasis.
• Used for alleviating symptoms like redness, irritation, and plaque formation.
• Used for long-term management of psoriasis, offering a reliable and effective solution.
• Used for its active form of vitamin D, aiding in skin repair and reducing psoriasis symptoms.
• Used for both the body and scalp, providing targeted treatment for affected areas.

In the case of an overdose of Calcipotriol Lotion, it is important to recognize the potential risks. Overapplication or excessive use may lead to an increased absorption of the active ingredient, resulting in heightened side effects. If you suspect an overdose, promptly seek medical advice. Symptoms of overdose may include skin irritation, redness, or a burning sensation. Always follow the prescribed dosage guidelines to minimize the risk of adverse effects.

In the case of a missed dose of Calcipotriol Lotion, it is generally recommended to apply the medication as soon as you remember. However, if it is almost time for your next scheduled application, skip the missed dose and continue with your regular schedule. Do not apply extra lotion to make up for the missed dose, as this may increase the risk of side effects. It is important to maintain a consistent treatment routine, but if you frequently miss doses, consult your healthcare provider for advice on how to optimize your treatment plan.

To apply Calcipotriol Lotion, clean and dry the affected skin area, then apply a thin layer of the lotion to the skin, gently rubbing it in as directed by your healthcare provider, typically once or twice daily.

Following are the conditions/situations to avoid when using Calcipotriol Lotion:

• Do not use if you are allergic to Calcipotriol or any of the other ingredients in the lotion.
• Avoid using Calcipotriol Lotion if you have severe kidney problems.
• Not suitable for individuals with hypercalcemia (high levels of calcium in the blood).
• Should not be used on skin with certain conditions like psoriasis vulgaris, eczema, or severe skin infections.
• Avoid using on skin that is sunburned, injured, or affected by other skin disorders.
• Do not use on areas of the body not affected by psoriasis.
• Not recommended for children under 12 years of age.
• Avoid using if you are pregnant or breastfeeding without medical advice.

The side effects of Calcipotriol Lotion may include:

• Skin irritation at the application site
• Redness or erythema
• Itching or pruritus
• Dry skin
• Burning sensation
• Skin peeling or scaling
• Skin inflammation (dermatitis)
• Allergic reactions (rare)

Following are the precautions and warnings for Calcipotriol Lotion:

• Avoid contact with eyes, nose, mouth, and other mucous membranes. If accidental contact occurs, rinse thoroughly with water.
• Calcipotriol may cause skin irritation or burning; use it exactly as prescribed by your doctor, and do not apply to broken or infected skin.
• Do not cover the treated area with airtight dressings or bandages as this may increase the absorption of the medication.
• Avoid excessive exposure to sunlight or UV rays, including tanning beds. Calcipotriol can make your skin more sensitive to sunlight.
• Do not use this medication on the face or groin area unless specifically instructed by your doctor.
• Wash your hands thoroughly after applying the lotion to avoid accidental transfer to other areas.
• Keep this medication away from children and pets. Store it in a cool, dry place, and do not use it if the lotion changes color or becomes discolored.

Following are the drug interactions for Calcipotriol Lotion:

• Calcipotriol may interact with topical corticosteroids; concurrent use may increase the risk of HPA axis suppression.
• Avoid using other topical medications (including coal tar, dithranol, or other vitamin D derivatives) without medical advice.
• Topical calcineurin inhibitors (like tacrolimus or pimecrolimus) can cause increased skin absorption of calcipotriol, leading to potential systemic effects.
• The use of phototherapy (UVB or PUVA) with calcipotriol may result in enhanced skin irritation and an increased risk of skin cancer.
• Calcipotriol may increase the sensitivity of the skin to sunlight, so sun exposure should be minimized during treatment.
• Concomitant use of other vitamin D supplements or derivatives can lead to hypercalcemia.
• Caution is advised when using occlusive dressings with calcipotriol, as it may enhance drug absorption and increase the risk of adverse effects.

Following are the food interactions for Calcipotriol Lotion:

• Grapefruit and grapefruit juice should be avoided as they can increase the absorption of Calcipotriol, leading to higher blood levels and potentially increasing the risk of side effects.
• Alcohol is not known to directly interact with Calcipotriol Lotion, but it's generally advisable to limit alcohol consumption when using any medication to avoid potential liver issues.
• Fatty meals may slightly delay the absorption of Calcipotriol, but this is not considered a significant interaction.
• Avoid consuming foods fortified with Vitamin D or taking Vitamin D supplements without medical advice, as excessive Vitamin D can lead to hypercalcemia.
• Limit the intake of dairy products if you are prone to calcium-related kidney stones, as Calcipotriol can increase calcium levels.
• Foods rich in calcium, like milk, cheese, and yogurt, should be consumed in moderation to maintain a balanced calcium intake.
• It is generally safe to eat a normal, healthy diet while using Calcipotriol Lotion, but always follow your healthcare provider's advice.
• No specific food restrictions are required, but maintaining a balanced diet is recommended for overall health.

Calcipotriol Lotion should be stored in a cool and dry location, preferably at room temperature, ensuring protection from direct sunlight and moisture. It is crucial to keep the lotion securely sealed within its original container to maintain its integrity and prevent contamination. Avoid storage in bathrooms or near heat-emitting appliances, as temperature fluctuations can impact the medication's effectiveness. Prioritize checking the expiration date before each application, and dispose of any unused or expired lotion appropriately. Instead of disposing of it through the toilet or sink, consult a pharmacist or healthcare professional for guidance on safe disposal practices. Additionally, maintain the medication in a secure location, inaccessible to children, to prevent accidental exposure.

Following are the quick tips for Calcipotriol Lotion:

• Wash your hands before and after applying the lotion to ensure hygiene.
• Clean and dry the affected skin area before applying the lotion.
• Apply a thin layer of lotion to the affected skin, gently rubbing it in.
• Avoid applying the lotion to healthy skin or areas not affected by psoriasis.
• Do not cover the treated area with bandages or tight clothing to allow the lotion to work effectively.
• Avoid excessive sun exposure and use sunscreen when going outdoors.
• Inform your doctor if your condition doesn't improve or worsens during treatment.