Calzem-SR (90mg) 20 Tablets

Diltiazem 90mg Tablet primarily works by inhibiting calcium channels in cardiac and vascular smooth muscle cells. This mechanism of action is crucial in its ability to reduce calcium influx into these cells. By blocking the entry of calcium, diltiazem causes smooth muscle relaxation, particularly in the coronary and peripheral arteries, leading to vasodilation. This vasodilation results in decreased peripheral vascular resistance and reduced afterload, ultimately lowering blood pressure. Additionally, diltiazem's effect on cardiac muscle cells slows the conduction of electrical impulses through the atrioventricular (AV) node, leading to decreased heart rate and myocardial contractility, which contributes to its therapeutic effects in managing cardiovascular conditions.

Diltiazem 90mg

Calcium channel blocker.

Tablet

The following are the uses of Diltiazem 90mg Tablet:

• Used for managing high blood pressure, helping to relax and widen blood vessels.
• Used for treating angina, reducing the frequency and severity of chest pain episodes.
• Used to control irregular heart rhythms, helping the heart beat more regularly.
• Used for preventing blood vessel spasms, especially in conditions like Raynaud's phenomenon.
• Used in specific types of headaches, such as cluster headaches, to reduce their occurrence.
• Used post-heart attack to support heart health and prevent complications.
• Used in combination with other medications to enhance overall heart health and treatment outcomes.
• Used as a long-term maintenance therapy to manage chronic cardiovascular conditions.

In the case of an overdose of Diltiazem 90mg Tablets, individuals may experience symptoms such as a significant drop in blood pressure, leading to dizziness, lightheadedness, and fainting. Other potential effects include a slow heart rate, weakness, and even cardiac arrest in severe cases. It is crucial to seek medical assistance promptly if an overdose is suspected, as early intervention can prevent these potentially life-threatening complications. Timely treatment can involve supportive care, monitoring vital signs, and managing symptoms to ensure the patient's safety and well-being.

In the case of a missed dose of Diltiazem 90mg Tablet, it is important to take action promptly. If you remember shortly after the missed dose, take the medication as soon as possible. However, if it is almost time for your next scheduled dose, skip the missed dose and continue with your regular dosing schedule. Do not double the dose to make up for a missed one, as this may increase the risk of side effects. If you miss multiple doses, contact your healthcare provider for guidance on how to safely resume your medication regimen.

To take Diltiazem 90mg Tablet, swallow the tablet whole with a glass of water, preferably at the same time each day, following the dosage instructions provided by your healthcare professional.

Here are the conditions or situations when Diltiazem 90mg Tablet should not be used:

• Must not be taken by individuals with a known allergy to Diltiazem or other calcium channel blockers.
• Contraindicated in patients with severe hypotension (very low blood pressure).
• Should not be used in patients with severe aortic stenosis (narrowing of the aortic valve in the heart).
• Not recommended for individuals with heart failure, unless specifically prescribed by a doctor.
• Avoid using if you have a heart rhythm disorder called sick sinus syndrome.
• Contraindicated in patients with a condition called AV block (a type of heart block) without a pacemaker.
• Should not be used in patients with severe liver disease or impaired liver function.
• Not suitable for individuals with a history of heart attack and heart disease (unstable angina).

The side effects of Diltiazem 90mg Tablet may include:

• Dizziness or lightheadedness
• Fatigue or weakness
• Headache
• Nausea and vomiting
• Constipation
• Slow heart rate (bradycardia)
• Swelling in the legs and ankles (peripheral edema)
• Skin rashes or flushing

Following are the precautions and warnings for Diltiazem 90mg Tablet:

• Individuals with known allergies to Diltiazem or any of its ingredients should not take this medication.
• Blood pressure should be monitored regularly during treatment, especially in patients with low blood pressure or heart conditions.
• Caution is advised for patients with liver or kidney disease, as Diltiazem may require dosage adjustments.
• This medication can affect heart rate, so caution is necessary for patients with heart rhythm disorders or those taking other medications that impact heart rate.
• Diltiazem may interact with other drugs; patients should inform their doctor about all medications they are currently taking.
• Patients should not abruptly stop taking Diltiazem without medical supervision, as it may lead to a worsening of the underlying condition.
• Elderly patients may be more sensitive to the effects of Diltiazem, so dosage adjustments might be required.

Following are the drug interactions for Diltiazem 90mg Tablet:

• Co-administration with beta-blockers can lead to increased risk of bradycardia and heart block, requiring close monitoring.
• When combined with digoxin, it may increase digoxin levels, thus necessitating careful monitoring of digoxin concentrations.
• Diltiazem can enhance the effects of antihypertensive agents, potentially causing excessive blood pressure reduction.
• Using it with other calcium channel blockers may result in additive effects and increased risk of side effects.
• The use of diltiazem with statins can elevate statin levels, increasing the risk of muscle-related side effects.
• It may interact with CYP3A4 inhibitors, leading to increased diltiazem levels and potential toxicity.
• Caution is advised when combining with CYP3A4 inducers, as it may reduce diltiazem's effectiveness.

Following are the food interactions for Diltiazem 90mg Tablet:

• Grapefruit and grapefruit juice consumption should be avoided as they can increase Diltiazem levels in the blood, potentially leading to increased side effects and cardiovascular complications.
• Alcohol intake should be minimized or avoided as it can enhance the sedative effects of Diltiazem, increasing the risk of dizziness and impaired coordination.
• Consuming a high-fat meal may slightly decrease the absorption of Diltiazem, but this effect is generally not clinically significant.
• Avoid Seville oranges and their juice, as they can affect the metabolism of Diltiazem, similar to grapefruit.
• Avoid aged cheeses and certain processed meats containing tyramine to prevent potential blood pressure issues.
• Avoid excessive caffeine intake as it may counteract the blood pressure-lowering effects of Diltiazem.
• Maintain a balanced diet, as Diltiazem may interact with certain vitamins and minerals, affecting their absorption.
• Always follow healthcare provider's advice regarding dietary restrictions and recommendations during Diltiazem therapy.

Diltiazem 90mg Tablets should be stored in a cool and dry place, preferably at room temperature, ensuring protection from light and moisture. The original container should be used to keep the tablets, providing a secure seal to maintain their integrity. Avoid exposing the medication to heat, including ovens, heaters, or direct sunlight, as it can degrade the quality. Regularly check the expiration date, and dispose of any expired or unused tablets promptly. Proper disposal is crucial; do not flush or pour them down the drain. Contact your pharmacist or local waste management authorities for guidance on safe disposal practices. Keep the medication away from children to prevent accidental consumption.

Following are the quick tips for Diltiazem 90mg Tablet:

• Take the tablet as directed by your doctor, typically 1-4 times daily.
• Swallow the tablet whole with a full glass of water, preferably with or after meals.
• Maintain a consistent schedule for taking the medication for better effectiveness.
• Avoid crushing, chewing, or breaking the tablet to preserve its effectiveness.
• Inform your doctor about all medications you're taking to prevent potential interactions.
• Store the tablets in a cool, dry place, away from direct sunlight and moisture.
• Do not share your medication with others, even if they have similar symptoms.