Canesten (0.1g) 6 Vaginal Tablets

Clotrimazole, an antifungal medication, exerts its therapeutic effect by disrupting the integrity of fungal cell membranes. Its primary target is ergosterol, a crucial component of these membranes. Clotrimazole binds to sterol 14α-demethylase, a key enzyme in the ergosterol biosynthetic pathway, thereby inhibiting its activity. This inhibition leads to a decrease in ergosterol production, which is essential for maintaining the structure and function of fungal cell membranes. As a result, the fungal cell membrane becomes more permeable, leading to the leakage of essential intracellular components and the eventual death of the fungal cells. This selective inhibition of fungal sterol synthesis is what makes clotrimazole effective against various fungal infections.

Clotrimazole

Antifungal (Azole).

Tablet

The following are the uses of Clotrimazole Tablet:

• Used for treating fungal skin infections such as athlete's foot, jock itch, and ringworm.
• Used for relieving itching, redness, and discomfort associated with fungal infections.
• Used for preventing the spread of infection to other areas of the skin.
• Used for addressing fungal infections that may occur in skin folds or moist areas.
• Used for managing fungal nail infections when applied as directed.
• Used for maintaining skin hygiene and preventing recurrent infections.
• Used for complementing other antifungal treatments as part of a comprehensive approach.

Take as per doctor's prescription. The dosage depends on what your doctor suggests to you, based on your age, weight, and immune system condition. Do not stop the medication abruptly.

In the case of an overdose of Clotrimazole Tablets, individuals may experience symptoms such as nausea, vomiting, and diarrhea. These symptoms are typically mild and self-limiting. It is important to contact a healthcare professional or poison control center for guidance if an overdose is suspected. They can provide specific recommendations based on the individual's health status and the amount of medication ingested. Prompt consultation can help manage any potential adverse effects and ensure the well-being of the person involved.

In the case of a missed dose of Clotrimazole Tablet, it is generally recommended to take the missed dose as soon as you remember. However, if it is almost time for your next scheduled dose, it is best to skip the missed dose and continue with your regular dosing schedule. Avoid taking a double dose to make up for a missed one, as this may increase the risk of side effects. If you miss several doses, contact your healthcare provider for advice on how to get back on track with your medication regimen safely.

To take Clotrimazole Tablets, place the tablet in your mouth and swallow it whole with a full glass of water, preferably with or after a meal, as directed by your healthcare professional, ensuring you follow the prescribed dosage and duration for effective treatment.

Following are the circumstances when Clotrimazole Tablet should not be used:

• Not suitable for individuals with a known allergy or hypersensitivity to Clotrimazole or other similar antifungal medications.
• Contraindicated in patients with liver impairment or severe liver disease, as it may cause further damage.
• Not recommended for those with a history of a rare blood disorder called aplastic anemia.
• Should not be used if the patient is currently taking certain medications that may interact negatively with Clotrimazole, such as warfarin or phenytoin.
• Avoid using Clotrimazole if you have a rare hereditary problem of galactose intolerance, severe lactase deficiency, or glucose-galactose malabsorption.

The side effects of Clotrimazole Tablet may include:

• Skin irritation or redness at the application site
• Mild burning or stinging sensation
• Itching or rash
• Allergic reactions (hives, swelling, difficulty breathing)
• Nausea and vomiting (if ingested)
• Headache
• Diarrhea (in rare cases)
• Abdominal pain (rare)

Following are the precautions and warnings for Clotrimazole Tablet:

• This medication is for external use only and should not be ingested. Avoid contact with eyes, nose, and mouth.
• Wash your hands before and after applying the tablet to avoid unnecessary exposure and potential irritation.
• Do not use Clotrimazole Tablet on open wounds, cuts, or severely inflamed skin.
• Avoid using the tablet on skin that is sunburned or showing signs of severe irritation.
• Do not cover the treated area with bandages or tight clothing, as this may increase the risk of skin irritation.
• Consult a doctor if your condition does not improve within 2 weeks of treatment or if it worsens.
• Keep out of reach of children and pets. Store in a cool, dry place away from direct sunlight.

Following are the drug interactions for Clotrimazole Tablet:

• Erythromycin, a macrolide antibiotic, may increase the risk of adverse effects when used with Clotrimazole, leading to increased plasma levels of both drugs.
• Rifampicin, an antituberculosis drug, can induce the metabolism of Clotrimazole, reducing its effectiveness.
• Anticoagulants like warfarin may interact with Clotrimazole, requiring close monitoring of INR (International Normalized Ratio) due to potential changes in warfarin activity.
• The risk of QTc prolongation and torsades de pointes may increase when Clotrimazole is used with other QTc-prolonging drugs like pimozide.
• Caution is advised when using Clotrimazole with H2-receptor antagonists like cimetidine, as it may lead to increased plasma concentrations of both drugs.
• Drugs that induce CYP3A4 enzyme activity, such as carbamazepine, can decrease Clotrimazole levels, potentially reducing its antifungal efficacy.
• Clotrimazole may increase the plasma concentrations of certain medications metabolized by CYP2C9, such as warfarin and phenytoin, requiring dosage adjustments.

Following are the food interactions for Clotrimazole Tablet:

• Grapefruit juice should be consumed with caution as it may affect the metabolism of Clotrimazole, potentially leading to increased drug levels in the body.
• Alcohol intake is generally not recommended during treatment with Clotrimazole, as it may cause liver-related side effects and increase the risk of adverse reactions.
• Avoid high-fat meals as they can increase the absorption of Clotrimazole, leading to higher blood levels and potentially increasing the risk of side effects.
• Limit caffeine consumption as Clotrimazole can increase its levels in the body, potentially causing caffeine-related side effects.
• Avoid eating grapefruit or drinking grapefruit juice as it may interfere with the breakdown of Clotrimazole, leading to higher drug levels and an increased risk of side effects.
• Dairy products like milk, cheese, and yogurt can potentially decrease the absorption of Clotrimazole, so consider separating these foods from medication by a few hours.
• Consult your doctor if you consume cranberry juice regularly, as it may affect the effectiveness of Clotrimazole.
• Follow the prescribed dosage and schedule, and inform your healthcare provider about all the medications and supplements you are taking to minimize potential food-drug interactions.

Clotrimazole Tablets should be stored in a cool and dry place, preferably at room temperature between 68°F and 77°F (20°C and 25°C). Keep the tablets in their original container, tightly sealed, to protect them from moisture and light. Avoid storing them in the bathroom or kitchen, as these areas can be susceptible to heat and humidity. Always check the expiration date and do not use the medication if it is past its expiry. When disposing of unused or expired tablets, do not throw them into the trash or flush them down the toilet. Instead, follow local guidelines for medication disposal or consult your pharmacist for advice on safe disposal methods. Keep the tablets out of children's reach to prevent accidental consumption.

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Following are the quick tips for Clotrimazole Tablet:

• Take the tablet orally, usually once or twice a day as directed by your doctor.
• Swallow the tablet whole with a full glass of water, do not crush or chew.
• Ensure you complete the full course of treatment, even if symptoms improve.
• Avoid consuming alcohol as it may increase the risk of liver problems.
• Inform your doctor if you have any liver or kidney issues before taking this medication.
• Store the tablets at room temperature, away from moisture and sunlight.
• Contact your doctor if your condition persists or worsens after treatment.