Cansaar (32mg) 20 Tablets

Candesartan, the active ingredient in Candesartan 32mg Tablets, is an angiotensin II receptor blocker (ARB). Its primary mechanism of action is to selectively block the binding of angiotensin II to the AT1 receptors in various tissues, including vascular smooth muscle and the adrenal glands. Angiotensin II is a potent vasoconstrictor and a key regulator of the renin-angiotensin-aldosterone system (RAAS). By blocking the AT1 receptors, candesartan prevents the binding of angiotensin II, which leads to vasodilation, reduced vascular resistance, and decreased blood pressure. This mechanism helps in the treatment of hypertension by lowering blood pressure without affecting heart rate, thus reducing the risk of cardiovascular events.

Candesartan 32mg

Angiotensin II Receptor Blocker

Tablet

The following are the uses of Candesartan 32mg Tablet:

• Used for treating high blood pressure (hypertension).
• Used to lower the risk of heart attacks and strokes in patients with a history of these conditions.
• Used to manage heart failure, improving symptoms and reducing hospital admissions.
• Used in patients with diabetes and kidney problems to protect kidney function.
• Used to slow down the progression of kidney disease and reduce protein loss in urine.
• Used as an alternative to ACE inhibitors, especially for patients intolerant to ACE inhibitors' side effects.
• Used to reduce arterial stiffness and improve vascular function.
• Used for long-term management, often combined with other medications for optimal blood pressure control.

In the case of an overdose of Candesartan 32mg Tablets, it is important to recognize the potential symptoms, which may include a significant drop in blood pressure, leading to dizziness, fainting, or even shock. Prompt action is necessary; contact a healthcare professional or poison control center for guidance. They will provide specific instructions, which may involve inducing vomiting or seeking emergency medical care, depending on the severity of the overdose. Quick response and appropriate medical intervention are crucial.

In the case of a missed dose of Candesartan 32mg Tablet, it is generally recommended to take the missed dose as soon as you remember. However, if it is almost time for your next scheduled dose, skip the missed dose and continue with your regular dosing schedule. Do not double the dose to make up for a missed one, as this may increase the risk of side effects. If you miss multiple doses, consult your healthcare professional for advice on how to safely resume your medication. It is important to maintain a consistent dosing routine for optimal therapeutic benefits.

To take Candesartan 32mg Tablet, swallow the tablet whole with a glass of water, preferably at the same time each day, following the dosage instructions provided by your healthcare professional, typically once daily.

Following are the conditions or circumstances when Candesartan 32mg Tablet should not be taken:

• Avoid if you have a known allergy or sensitivity to Candesartan or any other angiotensin II receptor blockers (ARBs).
• Do not take this medication if you are pregnant or planning to become pregnant, as it can cause harm to the fetus.
• Not recommended for individuals with severe liver disease or biliary obstruction.
• Contraindicated in patients with severe kidney disease or those undergoing dialysis.
• Should not be used in individuals with low blood pressure (hypotension) or conditions that may cause low blood pressure.
• Avoid if you have a history of angioedema (swelling of the face, lips, throat, or tongue) related to previous use of ARBs.
• Do not use in combination with aliskiren in patients with diabetes.
• Not suitable for children until adequate safety and efficacy have been established.

The side effects of Candesartan 32mg Tablet may include:

• Dizziness
• Headache
• Fatigue or weakness
• Nausea and vomiting
• Diarrhea
• Back pain
• High potassium levels (hyperkalemia)
• Abnormal liver function tests

Following are the precautions and warnings for Candesartan 32mg Tablet:

• This medication is not recommended for patients with severe hepatic impairment or those who are pregnant or breastfeeding. Discontinue use if pregnancy is detected.
• Patients with renal impairment may require a lower dose, and regular monitoring of kidney function is advised.
• Elderly patients may be more susceptible to the hypotensive effects of Candesartan, so they should be closely monitored.
• Candesartan can cause hyperkalemia, especially in patients with renal impairment, diabetes, or those using potassium-sparing diuretics. Monitor potassium levels regularly.
• Avoid using Candesartan in patients with a history of angioedema related to previous treatment with angiotensin-converting enzyme inhibitors.
• Discontinue use if significant decreases in blood pressure occur, and provide appropriate medical support.
• This medication may impair the ability to perform tasks requiring mental alertness, particularly when starting treatment or increasing the dose.
• Regular monitoring of blood pressure is recommended, especially during the initial phase of treatment or when the dose is adjusted.

Following are the drug interactions for Candesartan 32mg Tablet:

• Candesartan can increase blood levels of lithium, leading to lithium toxicity. Close monitoring of lithium levels is required.
• Nonsteroidal anti-inflammatory drugs (NSAIDs) may reduce the blood pressure-lowering effect of Candesartan.
• Candesartan can enhance the blood pressure-lowering effect of other antihypertensive medications, including beta-blockers and diuretics.
• The use of Candesartan with angiotensin-converting enzyme (ACE) inhibitors may increase the risk of kidney impairment, particularly in patients with renal artery stenosis.
• Potassium-sparing diuretics or potassium supplements may lead to elevated potassium levels when used with Candesartan.
• Candesartan may increase the risk of angioedema when used with neprilysin inhibitors.
• The effectiveness of Candesartan may be reduced by non-steroidal anti-inflammatory drugs (NSAIDs) and COX-2 inhibitors.

Following are the food interactions to be aware of when taking Candesartan 32mg Tablets:

• Avoid excessive salt intake as it can reduce the blood pressure-lowering effect of Candesartan.
• Limit the consumption of potassium-rich foods like bananas, oranges, and spinach, as Candesartan can increase potassium levels.
• Alcohol may increase the blood pressure-lowering effect of Candesartan, so it's best to avoid excessive alcohol consumption.
• Grapefruit and grapefruit juice should be consumed with caution as they may increase the levels of Candesartan in the blood, potentially causing an excessive drop in blood pressure.
• There is no significant impact on the absorption of Candesartan when taken with or without food, but it's best to follow the advice of your healthcare provider.
• Maintain a balanced diet, as Candesartan may be less effective if you follow a high-fat diet.
• Stay hydrated, as proper hydration can support the effectiveness of Candesartan in maintaining healthy blood pressure.

Candesartan 32mg Tablets should be stored in a cool, dry area, preferably at room temperature, ensuring it is kept away from direct sunlight, moisture, and heat sources like ovens or radiators. It is crucial to store the medication in its original packaging, tightly sealed, to maintain its integrity and prevent contamination. Always check the expiration date before use, and for proper disposal of any unused or expired tablets, consult a pharmacist or healthcare professional for guidance. Do not flush or pour the medication down the drain; instead, follow recommended disposal practices. Keep the tablets out of children's reach to prevent accidental consumption.

Following are the quick tips for Candesartan 32mg Tablet:

• Consult your doctor before starting this medication and provide your complete medical history.
• Inform your doctor about all the medicines you are currently taking to avoid any interactions.
• Store the tablets in a cool, dry place, away from direct sunlight and moisture.
• Take the tablet as a whole with a sufficient amount of water. Do not crush or chew.
• Maintain a consistent time for taking the tablet each day for better effectiveness.
• Regularly monitor your blood pressure and kidney function while on this medication.
• Do not stop taking the tablet without consulting your doctor to prevent complications.