Cansaar Plus (16/12.5mg) 20 Tablets

Hydrochlorothiazide and Candesartan work synergistically in the Hydrochlorothiazide 12.5mg, Candesartan 16mg Tablet. Hydrochlorothiazide, a thiazide diuretic, inhibits the reabsorption of sodium and chloride in the distal convoluted tubule of the kidney, promoting the excretion of water and reducing blood volume. This action helps lower blood pressure by decreasing preload. Candesartan, an angiotensin II receptor blocker, blocks the binding of angiotensin II to its receptors, primarily in the vascular smooth muscle. Angiotensin II is a potent vasoconstrictor, so by blocking its effects, candesartan causes vasodilation, reducing peripheral resistance and lowering blood pressure. Together, these mechanisms contribute to the antihypertensive effect of the combination therapy.

Hydrochlorothiazide 12.5mg, Candesartan 16mg

Angiotensin II Receptor Blocker (ARB) and Diuretic

Tablet

The following are the uses of Hydrochlorothiazide 12.5mg, Candesartan 16mg Tablet:

• Used for controlling high blood pressure (hypertension)
• Used to reduce the risk of stroke and heart attack
• Used to manage fluid retention (edema)
• Used to improve blood flow and relieve strain on the heart
• Used to treat diabetic kidney disease
• Used to prevent kidney damage in patients with hypertension and diabetes
• Used as part of a comprehensive treatment plan for cardiovascular health
• Used to enhance overall cardiovascular function and well-being

In the case of an overdose of Hydrochlorothiazide 12.5mg and Candesartan 16mg tablets, individuals may experience symptoms such as dizziness, lightheadedness, and an increased heart rate. It is important to seek medical advice promptly, as excessive amounts of these medications can lead to severe hypotension and electrolyte imbalances. Quick medical intervention is key to managing these symptoms and preventing potential complications. If an overdose is suspected, contact a healthcare professional or poison control center for guidance and support.

In the case of a missed dose of Hydrochlorothiazide 12.5mg, take it as soon as you remember, but if it's almost time for your next dose, skip the missed dose and continue with your regular schedule. For Candesartan 16mg, if you miss a dose, take it as soon as possible on the same day. However, if you don't remember until the next day, skip the missed dose and continue with your regular dosing schedule. It's important to try to take your medication at the same time each day to maintain a consistent routine.

To take the Hydrochlorothiazide 12.5mg and Candesartan 16mg Tablet, swallow the tablet whole with a glass of water, preferably at the same time each day, following the dosage instructions provided by your healthcare professional.

Following are the conditions or situations when Hydrochlorothiazide 12.5mg, Candesartan 16mg Tablet should not be used:

• Should not be used in patients with known allergies to Hydrochlorothiazide, Candesartan, or any of its components.
• Contraindicated in individuals with a history of severe kidney disease or those with anuria (absence of urine production).
• Not suitable for patients with severe liver disease or biliary obstruction.
• Should not be used in individuals with low potassium or sodium levels in the blood (hypokalemia or hyponatremia).
• Contraindicated during pregnancy and breastfeeding.
• Not recommended for individuals with gout or a history of gout attacks.
• Should be avoided in patients with a history of sulfonamide or penicillin allergy, as cross-reactivity may occur.
• Not suitable for those with diabetes who are also taking medication to control blood sugar levels.
• Should not be used in patients with severe dehydration or those who are unable to produce urine.

The side effects of Hydrochlorothiazide 12.5mg, Candesartan 16mg Tablet may include:

• Dizziness or lightheadedness
• Fatigue or weakness
• Electrolyte imbalances (such as low potassium or sodium levels)
• Increased sensitivity to sunlight
• Skin rashes or itching
• Gastrointestinal issues (e.g., nausea, diarrhea)
• Muscle cramps
• Joint pain

Following are the precautions and warnings for Hydrochlorothiazide 12.5mg, Candesartan 16mg Tablet:

• This medication should not be taken by individuals with a known allergy to hydrochlorothiazide, candesartan, or any other ACE inhibitors.
• Patients with kidney disease or liver problems should exercise caution and consult a doctor, as this medication may need dosage adjustments.
• It is important to regularly monitor blood pressure and kidney function while taking this medication, especially in elderly patients.
• Diabetic patients should be cautious as this medication may affect blood sugar levels.
• Dehydration is a risk, so ensure adequate fluid intake during treatment.
• Inform your doctor if you have a history of gout, as this medication may increase uric acid levels.
• Avoid potassium supplements and potassium-rich foods without medical advice, as this medication can increase potassium levels.

Following are the drug interactions for Hydrochlorothiazide 12.5mg and Candesartan 16mg Tablet:

• Lithium and non-steroidal anti-inflammatory drugs (NSAIDs) can decrease the blood pressure-lowering effect of hydrochlorothiazide.
• Candesartan may enhance the effects of other antihypertensive agents, increasing the risk of hypotension.
• When used with diuretics like hydrochlorothiazide, digoxin levels may be increased, requiring monitoring.
• Hydrochlorothiazide can raise blood calcium levels, potentially increasing the risk of digoxin toxicity.
• The combination with potassium-sparing diuretics may lead to hyperkalemia.
• Caution is advised with diabetic medications, as hydrochlorothiazide may alter blood sugar levels.
• The effectiveness of candesartan may be reduced by NSAIDs, especially in volume-depleted patients.

Following are the food interactions for Hydrochlorothiazide 12.5mg and Candesartan 16mg Tablet:

• Avoid excessive salt (sodium) in your diet. This medication may make your body lose more sodium, especially if you're on a low-salt diet, which can lead to electrolyte imbalances.
• Potassium-rich foods like bananas, oranges, and spinach should be consumed regularly as Hydrochlorothiazide can cause potassium loss.
• Limit alcohol consumption as it may increase the blood pressure-lowering effect of Candesartan, and when combined with Hydrochlorothiazide, it can also increase the risk of dizziness and lightheadedness.
• Grapefruit and grapefruit juice should be consumed in moderation as they may affect the metabolism of Candesartan, potentially increasing its levels in the blood.
• Maintain a balanced diet, as Hydrochlorothiazide may increase blood sugar levels and alter lipid profiles.
• Avoid licorice, especially if you have heart issues, as it may decrease the effectiveness of Candesartan.
• Stay hydrated, as this medication can cause increased urination.

Hydrochlorothiazide 12.5mg, Candesartan 16mg tablets should be stored in a cool and dry place, preferably at room temperature, ensuring protection from light and moisture. It is crucial to keep the medication in its original container, tightly sealed, to maintain its integrity. Do not expose the tablets to extreme temperatures or store them in bathrooms or near heat sources. Regularly check the expiration date, and if the medication is no longer needed or has expired, proper disposal is essential. Avoid flushing or pouring the tablets down the drain; instead, consult a pharmacist for safe disposal guidelines to prevent environmental contamination. Keep the medication securely stored, away from children, to prevent accidental consumption.

Following are the quick tips for Hydrochlorothiazide 12.5mg, Candesartan 16mg Tablet:

• Always take the medication as directed by your doctor or pharmacist.
• Ensure you understand the dosage instructions and take the tablet at the recommended time.
• Swallow the tablet whole with a full glass of water; do not crush or chew.
• Maintain a consistent schedule for taking the medication for maximum effectiveness.
• If you experience dizziness, rise slowly from a sitting or lying position.
• Inform your doctor about all the medications you are taking to avoid potential interactions.
• Store the medication in a cool, dry place, away from direct sunlight and moisture.