Capozide (50mg/25mg) 30 Tablets

Hydrochlorothiazide and Captopril are combined in this tablet to treat hypertension. Hydrochlorothiazide is a diuretic that increases urine production, leading to the removal of excess fluid and sodium from the body, which helps lower blood pressure. It inhibits the reabsorption of sodium and chloride ions in the distal convoluted tubule of the kidney, promoting the loss of water and reducing blood volume. Captopril, on the other hand, is an angiotensin-converting enzyme (ACE) inhibitor. It blocks the conversion of angiotensin I to angiotensin II, a potent vasoconstrictor. By inhibiting ACE, Captopril reduces the production of angiotensin II, leading to vasodilation and decreased blood pressure. This dual action of diuresis and vasodilation helps to effectively lower blood pressure in patients with hypertension.

Hydrochlorothiazide 25mg, Captopril 50mg

Thiazide diuretic, ACE inhibitor.

Tablet

The following are the uses of Hydrochlorothiazide 25mg, Captopril 50mg Tablet:

• Used for treating high blood pressure, helping to lower and control blood pressure.
• Used for reducing the risk of heart-related issues, such as heart attacks and strokes, by improving cardiovascular health.
• Used for managing fluid retention (edema) by increasing urine output and reducing excess fluid in the body.
• Used for supporting kidney health, particularly in patients with diabetic kidney disease or high blood pressure-related kidney issues.
• Used for improving overall cardiovascular function and reducing the workload on the heart.
• Used for treating certain types of heart failure, aiding in symptom management and improving quality of life.
• Used for preventing the progression of kidney damage in patients with hypertension and diabetes.

In the case of an overdose of Hydrochlorothiazide 25mg and Captopril 50mg tablets, symptoms may include severe hypotension, electrolyte imbalances, and possible kidney impairment. Prompt medical attention is necessary, and treatment should focus on managing symptoms and supporting vital functions. Gastrointestinal decontamination methods, such as activated charcoal, may be considered if the overdose is recent. Close monitoring of vital signs, blood pressure, and kidney function is essential during the management of an overdose.

In the case of a missed dose of Hydrochlorothiazide 25mg, it is generally advised to take the missed dose as soon as you remember, unless it is almost time for your next scheduled dose. If it is near the time of your next dose, skip the missed dose and continue with your regular dosing schedule. For Captopril 50mg tablets, if a dose is missed, take it as soon as possible, but if it is nearly time for your next dose, skip the missed dose and resume your regular dosing interval. It is important to try to take your medication at the same time each day to maintain a consistent level in your body.

To take the Hydrochlorothiazide 25mg and Captopril 50mg Tablet, swallow the tablet whole with a glass of water, preferably at the same time each day, following the dosage instructions provided by your healthcare provider or as directed on the prescription label.

Following are the conditions or situations when Hydrochlorothiazide 25mg, Captopril 50mg Tablet should not be used:

• Should not be used in patients with a known allergy to either Hydrochlorothiazide or Captopril or any other angiotensin-converting enzyme (ACE) inhibitors.
• Contraindicated in patients with a history of angioedema after previous treatment with ACE inhibitors.
• Not suitable for individuals with severe renal impairment or those who are anuric (not producing urine).
• Should not be used during pregnancy, especially in the second and third trimesters, as it can cause harm to the fetus.
• Contraindicated in patients with certain blood disorders, such as neutropenia or agranulocytosis.
• Not recommended for individuals with severe liver disease or progressive liver disorders.
• Should be avoided in patients with bilateral renal artery stenosis or unilateral stenosis in a solitary kidney.
• Not suitable for individuals with hyperkalemia (high potassium levels) or conditions that may cause hyperkalemia.
• Should not be used in patients who are also taking aliskiren, especially in those with diabetes or renal impairment.

The side effects of Hydrochlorothiazide 25mg, Captopril 50mg Tablet may include:

• Dizziness or lightheadedness
• Fatigue or weakness
• Nausea and vomiting
• Diarrhea or constipation
• Skin rash or itching
• Low blood pressure (hypotension)
• Increased sensitivity to sunlight
• Muscle cramps or joint pain

Following are the precautions and warnings for Hydrochlorothiazide 25mg, Captopril 50mg Tablet:

• This medication is contraindicated in patients who are hypersensitive to any component of the tablet or other ACE inhibitors.
• Patients with a history of angioedema should not use this medication as it may cause a recurrence.
• Regular monitoring of kidney function and blood electrolytes is necessary, especially in patients with pre-existing kidney disease.
• Caution should be exercised in patients with impaired liver function as hydrochlorothiazide is metabolized in the liver.
• May cause dizziness and lightheadedness, so patients should be cautious when driving or operating machinery.
• This medication may cause hyperkalemia, especially in patients with kidney impairment or those using potassium-sparing diuretics.
• Not recommended for use during pregnancy or breastfeeding unless the potential benefits outweigh the risks.
• Elderly patients may be more susceptible to the effects of this medication, particularly dizziness and changes in blood pressure.

Following are the drug interactions for Hydrochlorothiazide 25mg and Captopril 50mg Tablet:

• Lithium and non-steroidal anti-inflammatory drugs (NSAIDs) may increase the risk of lithium toxicity when used with Hydrochlorothiazide.
• Captopril can increase the levels of lithium and potentially cause lithium toxicity.
• The effectiveness of antihypertensive agents may be reduced when used with Hydrochlorothiazide, requiring dosage adjustments.
• When combined with Captopril, the risk of hyperkalemia (high potassium levels) may increase with potassium-sparing diuretics, potassium supplements, or potassium-containing salt substitutes.
• Hydrochlorothiazide may decrease the elimination of calcium channel blockers, potentially leading to increased side effects.
• Angiotensin-converting enzyme (ACE) inhibitors like Captopril can enhance the effects of hypoglycemic agents and insulin, potentially causing low blood sugar.
• The hypotensive effects of Captopril may be reduced by nonsteroidal anti-inflammatory drugs (NSAIDs), making blood pressure control more challenging.
• The use of Hydrochlorothiazide with other drugs that lower blood pressure may result in additive effects and potentially excessive hypotension.

Following are the food interactions for Hydrochlorothiazide 25mg and Captopril 50mg Tablet:

• Avoid excessive salt intake, as Hydrochlorothiazide is a diuretic and can lead to increased sodium loss, potentially causing electrolyte imbalances.
• Limit or avoid alcohol consumption as it may enhance the blood pressure-lowering effect of Captopril, leading to dizziness and lightheadedness.
• Potassium-rich foods like bananas, oranges, and spinach are recommended since Hydrochlorothiazide can cause potassium loss.
• Grapefruit and grapefruit juice should be consumed with caution, as they may affect the metabolism of Captopril, altering its effectiveness.
• Avoid high-sodium processed foods, as they can counteract the blood pressure-lowering effects of both medications.
• Maintain a balanced diet, as Hydrochlorothiazide may impact blood sugar levels, and Captopril may increase potassium levels.
• Stay hydrated, but be mindful of excessive fluid intake, especially if instructed to restrict fluids due to medical conditions.

Hydrochlorothiazide 25mg, Captopril 50mg Tablets should be stored in a cool and dry place, preferably at room temperature, ensuring protection from direct sunlight and moisture. The medication container should be tightly sealed to maintain its integrity and prevent contamination. It is crucial to avoid storing the tablets in bathrooms or near heat-emitting appliances to prevent temperature-related degradation. Regularly check the expiration date, and if the medication is no longer needed or has expired, proper disposal is essential. Do not flush or pour the tablets down the drain; consult a pharmacist or healthcare professional for guidance on safe disposal methods. Keep the medication securely stored away from children to prevent accidental consumption.

Following are the quick tips for Hydrochlorothiazide 25mg and Captopril 50mg Tablet:

• Consult your doctor or pharmacist for personalized advice on medication use.
• Ensure you understand the dosage instructions and take the medication as prescribed.
• Take the tablets with a full glass of water, preferably at the same time each day.
• Do not crush or chew the tablets; swallow them whole for effective absorption.
• Avoid taking potassium supplements or potassium-rich foods without medical advice.
• Monitor your blood pressure regularly while on this medication.
• Store the medication in a cool, dry place, away from direct sunlight and moisture.
• Inform your healthcare provider about any other medications you are taking to prevent interactions.